Inventors:
James L. Cook - Columbia MO, US
Cristi R. Cook - Columbia MO, US
Aaron M. Stoker - Columbia MO, US
Keiichi Kuroki - Columbia MO, US
Bridget Colleen Garner - Athens GA, US
Richard Evans - Columbia MO, US
Brandon Lee Roller - Naples FL, US
Prakash Sidha Jayabalan - Columbia MO, US
Assignee:
THE CURATORS OF THE UNIVERSITY OF MISSOURI - Columbia MO
International Classification:
C40B 30/04
C12Q 1/68
G01N 33/53
G01N 33/566
G01N 33/00
C40B 40/10
G01N 27/447
G01N 33/559
H01J 49/26
US Classification:
506 9, 435 611, 435 612, 435 71, 435 792, 436501, 436 86, 506 18, 204456, 250282
Abstract:
Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) are disclosed, using measurement of the expression level of certain polypeptides in a test sample from a subject, including MCP1, IL8, KC, MMP2, MMP3, IL6, MMP1, RANTES, MMP9, IL1B, Apolipoprotein A1, Apolipoprotein E, DCN, CILP and COMP. Related methods for monitoring OA treatment efficacy, diagnostic reagents, and kits are also described.