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Abha A Saini, Age 582 Norsham Way, Collegeville, PA 19426

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Known as:
Abha Arya Saini Abha A S Tyagi Abha A Tyagi Aa Saini
Related to:
Hilda Arur

Abha Saini Phones & Addresses

2 Norsham Way, Collegeville, PA 19426 (484) 831-5252 (301) 216-9695

105 Mill Grove Dr #105, Norristown, PA 19403

639 Mill Grove Dr #639, Norristown, PA 19403

Eagleville, PA

5101 River Rd, Bethesda, MD 20816 (301) 652-7780

5101 River Rd #1107, Bethesda, MD 20816 (301) 652-7780

North Potomac, MD

Montgomery, PA

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Mentions for Abha A Saini

Publications & IP owners

Us Patents

Human Brain Endothelial Cells And Growth Medium And Method For Expansion Of Primitive Cd34+Cd38-Bone Marrow Stem Cells

US Patent:
6642049, Nov 4, 2003
Filed:
Dec 3, 1999
Appl. No.:
09/452855
Inventors:
John P. Chute - San Francisco CA
Abha A. Saini - Collegeville PA
Dennis J. Chute - Los Angeles CA
Thomas A. Davis - Newton PA
Assignee:
The United States of America as represented by the Secretary of the Navy - Washington DC
International Classification:
C12N 500
US Classification:
435373, 435368, 435384, 435385
Abstract:
A novel co-culture system using human brain endothelial cells (HUBEC) which promotes the expansion of human CD34 CD38 cells consistent with the PMVEC system is disclosed. HUBEC were isolated from cadaveric donors, passed in primary culture, cloned and found to be Von Willebrand Factor positive. Cultivation of purified bone marrow CD34 cells on HUBEC monolayers supplemented with GM-CSF+IL-3+IL-6+SCF+flt-3 ligand caused a 14. 5-fold increase in total cells, an 6. 6-fold increase in CD34 cells, and, most remarkably, a 440-fold increase in CD34 CD38 cells after 7 days. Further, CFU-GM production increased 15. 1-fold, BFU-E increased 8-fold, and CFU-Mix increased 5. 2-fold. Optimal generation was dependent upon the continued presence of exogenous supplied cytokines. Moreover, we found that non-brain human endothelial cells isolated from the same donors supported neither the expansion nor the maintenance of human CD34 CD38 cells.

Possible Relatives

Davinder G Saini  Deepak Saini  Deepti Saini  Gagandeep Saini  Gurmeet Saini  Hardeep S Saini  Hari R Saini  Abha S Singh  Abha P Patel  Abha Sharma 

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