Inventors:
John Joseph Gaudino - Longmont CO, US
Adam Wade Cook - Broomfield CO, US
Assignee:
ICOS Corporation - Bothell WA
International Classification:
A61K 31/497
C07D 401/10
C07D 403/10
C07D 405/10
C07D 409/10
C07D 411/10
C07D 413/10
C07D 417/10
C07D 419/10
A61P 35/00
C07D 241/14
C07D 241/16
C07D 241/20
C07D 211/70
C07D 211/84
C07D 213/89
US Classification:
51425505, 544405, 544406, 544407, 544408, 544336, 546329, 548235, 548202, 548201, 548205, 548200, 564 74, 568940, 556422
Abstract:
Substituted urea compounds useful in the treatment of diseases and CalkyleneORconditions related to DNA damage or lesions in DNA replication are disclosed formula (I), wherein Xis null, —O—, —S—, —CH—, or —N(R)—; Xis —O—,. ->. -, or —N(R)—,—. . Y xs 0 or S; or =y represents two hydrogen atoms attached to a common carbon atom, —W is selected from the group consisting of heteroaryl, aryl, heterocycloalkyl, cycloalkyl, and alkyl substituted with a heteroaryl. or aryl group; Ris —C≡C—Ror heteroaryl; R, R, and R, independently, are selected from the group consisting of halo, optionally substituted Calkyl, Calkenyl, Calkynyl, OCP, CF, NO, CN, NC, N(R), OR, COR, C(O)N (R), C(O)R, N(R)COR, N(R)C(O)OR, N(R)C(O)OR, N(R)C(O)CalkyleneC(O)R, N(R)C(O)CalkyleneC(O)OR, N(R)C(O)CalkyleneOR, N(R)C(O)CalkyleneNHC(O)OR, N(R)C(O)CalkyleneSO. NR, CalkyleneOR, and SR; Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.
