Anne L Simmons, Age 48PO Box 25, Yosemite National Park, CA 95389
Anne Simmons Phones & Addresses
Yosemite National Park, CA
Dallas, TX
Mesquite, TX
Bolling AFB, DC
Hilliard, OH
Columbus, OH
Washington, PA
Wheeling, WV
Sandusky, OH
Work
Company:
United states house of representatives
Address:
1203 Lngwrth Hse Off Bldg, Washington, DC 20515
Phones:
(202) 225-6405
Position:
Senior professional staff member
Industries:
Legislative Bodies
Mentions for Anne L Simmons
Publications & IP owners
Us Patents
Structural Modification Of 19-Norprogesterone I: 17-Α-Substituted-11-Β-Substituted-4-Aryl And 21-Substituted 19-Norpregnadienedione As New Antiprogestational Agents
US Patent:
6900193, May 31, 2005
Filed:
Mar 17, 2000
Appl. No.:
09/526855
Inventors:
Hyun K. Kim - Bethesda MD, US
Richard P. Blye - Highland MD, US
Pemmaraju N. Rao - San Antonio TX, US
James W. Cessac - San Antonio TX, US
Carmie K. Acosta - San Antonio TX, US
Anne Marie Simmons - San Antonio TX, US
Richard P. Blye - Highland MD, US
Pemmaraju N. Rao - San Antonio TX, US
James W. Cessac - San Antonio TX, US
Carmie K. Acosta - San Antonio TX, US
Anne Marie Simmons - San Antonio TX, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K031/56
A61K031/58
C07J005/00
C07J009/00
C07J043/00
A61K031/58
C07J005/00
C07J009/00
C07J043/00
US Classification:
514179, 514176, 514177, 514182, 514841, 540107, 552556, 552595, 552598, 552602, 552608
Abstract:
The present invention relates, inter alia, to compounds having the general formula: in which: Ris a member selected from the group consisting of —OCH, —SCH, —N(CH), —NHCH, —NCH, —NCH, —NCHO, —CHO, —CH(OH)CH, —C(O)CH, —O(CH)N(CH), and —O(CH)NCH; Ris a member selected from the group consisting of hydrogen, halogen, alkyl, acyl, hydroxy, alkoxy (e. g. , methoxy, ethoxy, vinyloxy, ethynyloxy, cyclopropyloxy, etc. ), acyloxy (e. g. , acetoxy, glycinate, etc. ), alkylcarbonate, cypionyloxy, S-alkyl, —SCN, S-acyl and —OC(O)R, wherein Ris a functional group including, but not limited to, alkyl (e. g. , methyl, ethyl, etc. ), alkoxy ester (e. g. , —CHOCH) and alkoxy (—OCH); Ris a member selected from the group consisting of alkyl, hydroxy, alkoxy and acyloxy; Ris a member selected from the group consisting of hydrogen and alkyl; and X is a member selected from the group consisting of ═O and ═N—OR, wherein Ris a member selected from the group consisting of hydrogen and alkyl. In addition to providing the compounds of Formula I, the present invention provides methods wherein the compounds of Formula I are advantageously used, inter alia, to antagonize endogenous progesterone; to induce menses; to treat endometriosis; to treat dysmenorrhea; to treat endocrine hormone-dependent tumors; to treat meningiomas; to treat uterine leiomyomas; to treat uterine fibroids; to inhibit uterine endometrial proliferation; to induce cervical ripening; to induce labor; and for contraception.
Process For Preparing17Alpha-Acetoxy-11Beta-[4-N,N(Dimethylamino)Phenyl]-21-Methoxy-19-Norpregna-4,9-Diene -3,20-Dione, Intermediates Useful In The Process , And Processes For Preparing Such Intermediates
US Patent:
2003006, Mar 27, 2003
Filed:
Jun 27, 2002
Appl. No.:
10/169139
Inventors:
Hyun Kim - Bethesda MD, US
Pemmaraju Rao - San Antonio TX, US
James Cessac - San Antonio TX, US
Anne Simmons - San Antonio TX, US
Pemmaraju Rao - San Antonio TX, US
James Cessac - San Antonio TX, US
Anne Simmons - San Antonio TX, US
International Classification:
C07J053/00
US Classification:
552/500000, 540/500000
Abstract:
A compound having general formula (I) in which Ris a member selected from the group consisting of —OCH, —SCH, —N(CH), —NHCH, —CHO, —COCHand —CHOHCH; Ris a member selected from the group consisting of halogen, alkyl, acyl, hydroxy, alkoxy, acyloxy, alkyl carbonate, cypionyloxy, S-alkyl and S-acyl; Ris a member selected from the group consisting of alkyl, hydroxy, alkoxy and acyloxy; Ris a member selected from the group consisting of hydrogen and alkyl; and X is a member selected from the group consisting of —O and —N—OR, wherein Ris a member selected from the group consisting of hydrogen and alkyl. In addition to providing the compounds of formula (I), the present invention provides methods wherein the compounds of formula (I) are advantageously used, inter alia. to antagonize endogenous progesterone; to induce menses; to treat endometriosis; to treat dysmenorrhea; to treat endocrine hormone-dependent tumors; to treat uterine fibroids; to inhibit uterine endometrial proliferation; to induce labor; and for contraception.
Structural Modification Of 19-Norprogesterone I: 17-Alpha-Substituted-11-Beta-Substituted-4-Aryl And 21-Substituted 19-Norpregnadienedione As New Antiprogestational Agents
US Patent:
2005014, Jun 30, 2005
Filed:
Feb 28, 2005
Appl. No.:
11/069817
Inventors:
Hyun Kim - Bethesda MD, US
Richard Blye - Highland MD, US
Pemmaraju Rao - San Antonio TX, US
James Cessac - San Antonio TX, US
Carmie Acosta - San Antonio TX, US
Anne Simmons - San Antonio TX, US
Richard Blye - Highland MD, US
Pemmaraju Rao - San Antonio TX, US
James Cessac - San Antonio TX, US
Carmie Acosta - San Antonio TX, US
Anne Simmons - San Antonio TX, US
International Classification:
A61K031/58
C07J041/00
C07J041/00
US Classification:
514179000, 552575000
Abstract:
The present invention relates, inter alia, to compounds having the general formula: in which: Ris a member selected from the group consisting of —OCH, —SCH, —N(CH), —NHCH, —NCH, —NCH, —NCHO, —CHO, —CH(OH)CH, —C(O)CH, —O(CH)N(CH), and —O(CH)NCH; Ris a member selected from the group consisting of hydrogen, halogen, alkyl, acyl, hydroxy, alkoxy (e.g., methoxy, ethoxy, vinyloxy, ethynyloxy, cyclopropyloxy, etc.), acyloxy (e.g., acetoxy, glycinate, etc.), alkylcarbonate, cypionyloxy, S-alkyl, —SCN, S-acyl and —OC(O)R, wherein Ris a functional group including, but not limited to, alkyl (e.g., methyl, ethyl, etc.), alkoxy ester (e.g., —CHOCH) and alkoxy (—OCH); Ris a member selected from the group consisting of alkyl, hydroxy, alkoxy and acyloxy; Ris a member selected from the group consisting of hydrogen and alkyl; and X is a member selected from the group consisting of ═O and ═N—OR, wherein Ris a member selected from the group consisting of hydrogen and alkyl. In addition to providing the compounds of Formula I, the present invention provides methods wherein the compounds of Formula I are advantageously used, inter alia, to antagonize endogenous progesterone; to induce menses; to treat endometriosis; to treat dysmenorrhea; to treat endocrine hormone-dependent tumors; to treat meningiomas; to treat uterine leiomyomas; to treat uterine fibroids; to inhibit uterine endometrial proliferation; to induce cervical ripening; to induce labor; and for contraception.
Method For Preparing 17 Alpha-Acetoxy-11Beta-(4-N,N-Dimethylaminophenyl)-19-Norpregna-4,9-Diene-3,20-Dione, Intermediates Thereof, And Methods For The Preparation Of Such Intermediates
US Patent:
2006011, May 25, 2006
Filed:
Feb 13, 2004
Appl. No.:
10/542580
Inventors:
Hyun Kim - Bethesda MD, US
Pemmaraju Rao - San Antonio TX, US
Anne Simmons - San Antonio TX, US
Pemmaraju Rao - San Antonio TX, US
Anne Simmons - San Antonio TX, US
International Classification:
C07J 5/00
C07J 7/00
C07J 7/00
US Classification:
552557000
Abstract:
Methods for the preparation of the 19-norprogesterone of formula I and its intermediates, in crystalline and amorphous forms.
Structural Modification Of 19-Norprogesterone I: 17-Alpha-Substituted-11-Beta-Substituted-4-Aryl And 21-Substituted 19-Norpregnadienedione As New Antiprogestational Agents
US Patent:
2014010, Apr 17, 2014
Filed:
Sep 10, 2013
Appl. No.:
14/023131
Inventors:
- Bethesda MD, US
Richard P. Blye - Highland MD, US
Pemmaraju N. Rao - San Antonio TX, US
James W. Cessac - Floresville TX, US
Carmie K. Acosta - San Antonio TX, US
Anne Marie Simmons - San Antonio TX, US
Richard P. Blye - Highland MD, US
Pemmaraju N. Rao - San Antonio TX, US
James W. Cessac - Floresville TX, US
Carmie K. Acosta - San Antonio TX, US
Anne Marie Simmons - San Antonio TX, US
Assignee:
The United States of America, as represented by the Secretary, Department of Health and Human Serv - Bethesda MD
International Classification:
C07J 41/00
C07J 43/00
C07J 43/00
US Classification:
514176, 552598, 552608, 552554, 514179, 540 97, 552520
Abstract:
Disclosed are compounds having the general formula:wherein R-Rand X are as defined herein, pharmaceutical compositions including such compounds, and a method of treating a patient involving antagonizing the endogenous progesterone, such as in inducing menses and treating endometriosis, dysmenorrhea, endocrine hormone-dependent tumors, meningiomas, uterine leiomyomas, or uterine fibroids, inhibiting uterine endometrial proliferation, inducing cervical ripening, inducing labor, and in contraception.
Isbn (Books And Publications)
Child'S Play: Vigorous Activities With A Limited Budget
Author:
Anne Simmons
ISBN #:
0398046115
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