Inventors:
William N. Washburn - Titusville NJ
Ravindar N. Girotra - Lawrenceville NJ
Philip M. Sher - Plainsboro NJ
Amarendra B. Mikkilineni - Easton PA
Kathleen M. Poss - Lawrenceville NJ
Arvind Mathur - Basking Ridge NJ
Gregory S. Bisacchi - Ringoes NJ
Ashvinikumar V. Gavai - Plainsboro NJ
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K 3118
A61K 3122
A61K 31275
A61K 3138
Abstract:
Compounds of the formula ##STR1## or pharmaceutically acceptable salts thereof wherein: A is a bond, --(CH. sub. 2). sub. n -- or --CH(B)--, where n is an integer of 1 to 3 and B is --CN, --CON(R. sup. 9)R. sup. 9' or --CO. sub. 2 R. sup. 7 ; R. sup. 1 is lower alkyl, aryl or arylalkyl; R. sup. 2 is hydrogen, hydroxy, alkoxy, --CH. sub. 2 OH, cyano, --C(O)OR. sup. 7, --CO. sub. 2 H, --CONH. sub. 2, tetrazole, --CH. sub. 2 NH. sub. 2 or halogen; ##STR2## R. sup. 3 is hydrogen, alkyl, heterocycle or R. sup. 4 is hydrogen, alkyl or B; R. sup. 5, R. sup. 5', R. sup. 8, R. sup. 8' or R. sup. 8" are independently hydrogen, alkoxy, lower alkyl, halogen, --OH, --CN, --(CH. sub. 2). sub. n NR. sup. 6 COR. sup. 7, --CON(R. sup. 6)R. sup. 6', --CON(R. sup. 6)OR. sup. 6', --CO. sub. 2 R. sup. 6, --SR. sup. 7, --SOR. sup. 7, --SO. sub. 2 R. sup. 7, --N(R. sup. 6)SO. sub. 2 R. sup. 1, --N(R. sup. 6)R. sup. 6', --NR. sup. 6 COR. sup. 7, --OCH. sub. 2 CON(R. sup. 6)R. sup. 6', --OCH. sub. 2 CO. sub. 2 R. sup.