Brian J Frankowski, Age 60570 Engelman Dr, Imperial, PA 15126

8569052, Oct 29, 2013

May 25, 2011

13/115532

William J. Federspiel - Pittsburgh PA, US
Brian J. Frankowski - Imperial PA, US
Tatsuro Yoshida - West Newton MA, US
Paul J. Vernucci - Billerica MA, US

New Health Sciences, Inc. - Bethesda MD
University of Pittsburgh-Of the Commonwealth System of Higher Education - Pittsburgh PA

C12N 5/00

435325, 4352831

An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers. The hollow fibers are adapted to receiving and conveying red blood cells. There is another embodiment of an oxygen depletion device and method for removing oxygen from red blood cells.

8647569, Feb 11, 2014

Apr 11, 2011

13/084100

William J. Federspiel - Pittsburgh PA, US
Brian J. Frankowski - Imperial CA, US
Brendan C. Mack - Pasadena CA, US
Scott W. Morley - Pittsburgh PA, US
Meir Rosenberg - Newtown MA, US
Robert G. Svitek - Pittsburgh PA, US

ALung Technologies, Inc - Pittsburgh PA

A61M 1/00
A61M 37/00
B01D 63/00
C02F 1/44

422 45, 422 48, 604 614, 21032178

A paracorporeal respiratory assist lung is configured with an annular cylindrical hollow fiber membrane (fiber bundle) that is rotated at rapidly varying speeds. Fluid (for example, blood) is introduced to the center of the device and is passed radially through the fiber bundle. The bundle is rotated at rapidly changing velocities with a rotational actuator (for example, a motor or magnetic coupling). The rotation of the fiber bundle provides centrifugal kinetic energy to the fluid giving the device pumping capabilities and may create Taylor vortexes to increase mass transfer. Rotation of the fiber bundle increases the relative velocity between the fluid and the hollow fibers and increases the mass transfer. The porosity of the fiber bundle may be varied to enhance gas exchange with the blood. Alternatively, a rotating core may be used with a stationary fiber bundle.

2004022, Nov 11, 2004

May 9, 2003

10/434555

Brian Frankowski - Pittsburgh PA, US
William Federspiel - Pittsburgh PA, US
Joseph Golob - Pittsburgh PA, US
Brack Hattler - Pittsburgh PA, US

A61B005/00
A61M025/09

600/585000

A system for placement of a medical device in a body passage including a first and second guidewire, each configured with magnets on their distal ends. The guidewires are inserted through different access sites of a body passage and blindly connected using the magnets. The first guidewire is inserted into a first insertion site and the second guidewire is inserted into a second insertion site. Once the distal ends of the guidewires are attached, the second guidewire can then be removed from the first insertion site, detached from the first guidewire and attached to a medical device. The distal end of the second guidewire can then be pulled through the second insertion site to guide the medical device into a desired location in the body passage.

2006026, Nov 23, 2006

Apr 21, 2006

11/408576

Brack Hattler - Pittsburgh PA, US
William Federspiel - Pittsburgh PA, US
Brian Frankowski - Imperial PA, US

A61M 37/00

604026000

A compact,intravenous, percutaneous respiratory assist catheter having a rotating fiber bundle functions as an intravenous oxygenerator configured to be implanted within the patient's vasculature. The respiratory assist catheter provides oxygen introduction and carbon dioxide removal from the blood of the patient. the catheter includes hollow, gas-permeable fibers extending between a distal manifoldand a proximal manifold that permit diffusion of gases between the blood vessel and the interior of the fibers. An implantable version of the catheter is configured with a fiber bundle having increased porosity and with a mechanism to prevent the fiber bundle from damaging the vena cava. The fiber bundle may be protected by a wire loom or coil cage made from materials such as nitinol and stainless steel. The rotation of the fiber bundle may be varied in speed and in direction.

2007002, Jan 25, 2007

Apr 21, 2006

11/408650

William Federspiel - Pittsburgh PA, US
Brian Frankowski - Imperial PA, US
Brendan Mack - Pasadena CA, US
Scott Morley - Pittsburgh PA, US
Meir Rosenberg - Newton MA, US
Robert Svitek - Pittsburgh PA, US

A61M 37/00

422045000, 604006140

A paracorporeal respiratory assist lung is configured with an annular cylindrical hollow fiber membrane (fiber bundle) that is rotated at rapidly varying speeds. Fluid (for example, blood) is introduced to the center of the device and is passed radially through the fiber bundle. The bundle is rotated at rapidly changing velocities with a rotational actuator (for example, a motor or magnetic coupling). The rotation of the fiber bundle provides centrifugal kinetic energy to the fluid giving the device pumping capabilities and may create Taylor vortexes to increase mass transfer. Rotation of the fiber bundle increases the relative velocity between the fluid and the hollow fibers and increases the mass transfer. The porosity of the fiber bundle may be varied to enhance gas exchange with the blood. Alternatively, a rotating core may be used with a stationary fiber bundle.

2010033, Dec 30, 2010

Feb 6, 2009

12/865958

Brian J. Frankowski - Imperial PA, US
William J. Federspiel - Pittsburgh PA, US
Kevin M. Mihelc - Somerville MA, US
Samuel C. Lieber - Jersey City NJ, US

A61M 37/00

604 26

A system for intracorporeal gas exchange includes a flexible, rotatable shaft; a plurality of axially spaced agitation mechanisms positioned on the rotatable shaft, such that the rotatable shaft can flex between the axially spaced agitation mechanisms; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between intracorporeal fluid and an interior of the hollow fibers. The plurality of hollow fibers is positioned radially outward from the agitation mechanisms. A blood contacting medical system includes at least one seal, and a purge system via which a flushing fluid is introduced under pressure over a blood-side face of the seal and caused to flow through a space on the blood side of the seal. The system can further include a rotatable member. The space on the blood side of the seal can be in fluid connection with an annular space adjacent to a rotating element operatively connected to the rotatable member.

2012012, May 24, 2012

Jul 31, 2010

13/387528

William J. Federspiel - Pittsburgh PA, US
Tatsuro Yoshida - W. Newton MA, US
Paul J. Vernucci - Billerica MA, US
Brian Joseph Frankowski - Imperial PA, US
Laura Wheeler Lund - Pittsburgh PA, US

A61M 1/36

435 2, 422 44

A system for reducing the concentration of oxygen in a fluid including red blood cells includes a housing, a plurality of hollow tubes extending within the housing and adapted for flow of the fluid therethrough, wherein each tube includes an inlet and an outlet, and a carrier system that reduces the concentration of oxygen at an exterior surface of the tubes to facilitate transport of oxygen from the fluid flowing through the tubes to an exterior of the tubes.

2021007, Mar 18, 2021

Jan 15, 2019

16/961440

- Pitsburgh PA, US
- Starkville MS, US
Ryan A. Orizondo - Pittsburgh PA, US
Peter Drew Wearden - Orlando FL, US
Brian Joseph Frankowski - Imperial PA, US
Alexandra May - Miami FL, US
Gregory Burgreen - Starkville MS, US

University of Pittsburgh - Of theCommonwealth System of Higher Education - Pitsburgh PA
Mississippi State University - Starkville MS

A61M 1/36
A61M 1/16

A system for lung assist includes a plurality of fiber bundle sections which includes a fiber bundle housing defining a fiber bundle compartment with a fiber bundle positioned within. The fiber bundle includes a plurality of hollow gas permeable fibers. The fiber bundle housing further includes a gas inlet in fluid connection with the fiber bundle housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers, a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers, and a blood outlet in fluid connection with a first end of the fiber bundle. The system further includes a base section including a housing including a pressurizing compartment, a pressurizing mechanism within the pressurizing compartment, a blood inlet in fluid connection with the pressurizing compartment and a conduit.