Inventors:
- Cambridge MA, US
Debra Mazaik - Cambridge MA, US
Gordon Wilkie - Cambridge MA, US
Joshua D. Waetzig - Cambridge MA, US
Brian Heinrich - Cambridge MA, US
Lauren MacEachern - Dartmouth, CA
Dominik Siegel - Dottikon, CH
Harald Ohmer - Dottikon, CH
Steven C. Johnston - Woburn MA, US
International Classification:
C07D 487/04
Abstract:
Various salt forms of Compound (I) represented by the following structural formula, and their corresponding pharmaceutical compositions, are disclosed. Particular single crystalline forms of 1:1.5 Compound (I) succinate, 1:1 Compound (I) hydrochloride salt, and 1:1 Compound (I) fumarate salt are characterized by a variety of properties and physical measurements. Methods of preparing specific crystalline forms are also disclosed. The present disclosure also provides methods of treating or ameliorating fibrodysplasia ossificans progressive in a subject.