Brian Lawhorn resumes & CV records
Resumes
Brian Lawhorn
Brian Lawhorn
Brian G Lawhorn, Age 482022 Rockwall Farms Ln, Fuquay Varina, NC 27526
Brian Lawhorn Phones & Addresses
Fuquay Varina, NC
Roanoke, VA
Raleigh, NC
123 Ridgewood Cir, Downingtown, PA 19335 (484) 593-0366
West Chester, PA
Solana Beach, CA
Blue Ridge, VA
Brooktondale, NY
Richmond, VA
Delano, CA
Chester, PA
123 Ridgewood Cir, Downingtown, PA 19335
Work
Position:
Clerical/White Collar
Education
Degree:
Associate degree or higher
Mentions for Brian G Lawhorn
Publications & IP owners
Us Patents
Renin Inhibitors
US Patent:
2010013, May 27, 2010
Filed:
Apr 4, 2008
Appl. No.:
12/450619
Inventors:
John J. Baldwin - Gwynedd Valley PA, US
Salvacion Cacatian - Blue Bell PA, US
David Claremon - Maple Glen PA, US
Lawrence W. Dillard - Yardley PA, US
Patrick T. Flaherty - Pittsburgh PA, US
Damiamo Ghirlanda - Legnago, IT
Xiaoping Hou - Pennington NJ, US
Lara S. Kallander - King of Prussia PA, US
Beth A. Knapp-Reed - King of Prussia PA, US
Brian Lawhorn - King of Prussia PA, US
Qing Lu - King of Prussia PA, US
Gerard McGeehan - Garnet Valley PA, US
Simon Semus - Collegeville PA, US
Robert D. Simpson - Wilmington DE, US
Suresh B. Singh - Kendall Park NJ, US
Lamont R. Terrell - King of Prussia PA, US
Colin Tice - Ambler PA, US
Tritin Tran - King of Prussia PA, US
Zhenrong Xu - Horsham PA, US
Jing Yuan - Lansdale PA, US
Jing Zhang - Waltham MA, US
Wei Zhao - Eagleville PA, US
Salvacion Cacatian - Blue Bell PA, US
David Claremon - Maple Glen PA, US
Lawrence W. Dillard - Yardley PA, US
Patrick T. Flaherty - Pittsburgh PA, US
Damiamo Ghirlanda - Legnago, IT
Xiaoping Hou - Pennington NJ, US
Lara S. Kallander - King of Prussia PA, US
Beth A. Knapp-Reed - King of Prussia PA, US
Brian Lawhorn - King of Prussia PA, US
Qing Lu - King of Prussia PA, US
Gerard McGeehan - Garnet Valley PA, US
Simon Semus - Collegeville PA, US
Robert D. Simpson - Wilmington DE, US
Suresh B. Singh - Kendall Park NJ, US
Lamont R. Terrell - King of Prussia PA, US
Colin Tice - Ambler PA, US
Tritin Tran - King of Prussia PA, US
Zhenrong Xu - Horsham PA, US
Jing Yuan - Lansdale PA, US
Jing Zhang - Waltham MA, US
Wei Zhao - Eagleville PA, US
International Classification:
A61K 31/445
A61K 31/554
A61K 31/55
A61K 31/551
A61K 31/549
A61K 31/5377
A61K 31/5375
A61K 31/4545
C07D 417/12
C07D 265/30
C07D 401/06
C07D 401/10
C07D 211/34
A61P 25/00
A61P 9/12
A61P 9/10
A61K 31/554
A61K 31/55
A61K 31/551
A61K 31/549
A61K 31/5377
A61K 31/5375
A61K 31/4545
C07D 417/12
C07D 265/30
C07D 401/06
C07D 401/10
C07D 211/34
A61P 25/00
A61P 9/12
A61P 9/10
US Classification:
51421107, 51421207, 514221, 5142235, 5142355, 5142362, 5142375, 514316, 514318, 514330, 544133, 544165, 546189, 546194, 546226
Abstract:
Described are compounds which bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described are methods of use of the compounds described herein in ameliorating or treating aspartic protease related disorders in a subject in need thereof.
Renin Inhibitors
US Patent:
2010017, Jul 15, 2010
Filed:
Apr 4, 2008
Appl. No.:
12/450631
Inventors:
Jonh J. Baldwin - Gwynedd Valley PA, US
Salvacion Cacatian - Blue Bell PA, US
David Claremon - Maple Glen PA, US
Lawrence W. Dillard - Yardley PA, US
Patrick T. Flaherty - Pittsburgh PA, US
Damiano Ghirlanda - Legnago, IT
Alexey V. Ishchenko - Somerville MA, US
Lara S. Kallander - King of Prussia PA, US
Brian Lawhorn - King of Prussia PA, US
Colin A. Leach - Collegeville PA, US
Qing Lu - King of Prussia PA, US
Gerard McGeehan - Garnet Valley PA, US
Jaclyn R. Patterson - King of Prussia PA, US
Robert D. Simpson - Wilmington DE, US
Suresh B. Singh - Kendall Park NJ, US
Patrick Stoy - King of Prussia PA, US
Lamont R. Terrell - King of Prussia PA, US
Colin Tice - Ambler PA, US
Zhenrong Xu - Horsham PA, US
Jing Yuan - Lansdale PA, US
Catherine C. K. Yuan - King of Prussia PA, US
Jing Zhang - Waltham MA, US
Wei Zhao - Eagleville PA, US
Salvacion Cacatian - Blue Bell PA, US
David Claremon - Maple Glen PA, US
Lawrence W. Dillard - Yardley PA, US
Patrick T. Flaherty - Pittsburgh PA, US
Damiano Ghirlanda - Legnago, IT
Alexey V. Ishchenko - Somerville MA, US
Lara S. Kallander - King of Prussia PA, US
Brian Lawhorn - King of Prussia PA, US
Colin A. Leach - Collegeville PA, US
Qing Lu - King of Prussia PA, US
Gerard McGeehan - Garnet Valley PA, US
Jaclyn R. Patterson - King of Prussia PA, US
Robert D. Simpson - Wilmington DE, US
Suresh B. Singh - Kendall Park NJ, US
Patrick Stoy - King of Prussia PA, US
Lamont R. Terrell - King of Prussia PA, US
Colin Tice - Ambler PA, US
Zhenrong Xu - Horsham PA, US
Jing Yuan - Lansdale PA, US
Catherine C. K. Yuan - King of Prussia PA, US
Jing Zhang - Waltham MA, US
Wei Zhao - Eagleville PA, US
International Classification:
A61K 31/675
C07D 211/34
A61K 31/445
C07D 265/30
A61K 31/5375
C07D 413/06
A61K 31/5377
A61K 31/535
A61K 31/517
A61K 31/554
A61K 31/4965
A61K 31/5415
A61K 31/55
A61K 31/551
A61K 31/47
A61K 31/566
A61P 25/28
A61P 33/06
A61P 31/18
A61P 9/12
A61P 9/10
A61P 25/22
A61P 27/06
C07D 211/34
A61K 31/445
C07D 265/30
A61K 31/5375
C07D 413/06
A61K 31/5377
A61K 31/535
A61K 31/517
A61K 31/554
A61K 31/4965
A61K 31/5415
A61K 31/55
A61K 31/551
A61K 31/47
A61K 31/566
A61P 25/28
A61P 33/06
A61P 31/18
A61P 9/12
A61P 9/10
A61P 25/22
A61P 27/06
US Classification:
514 91, 546226, 514330, 544162, 5142375, 544131, 5142355, 5142335, 544146, 51425217, 51421107, 51425506, 5142242, 51421207, 514221, 514307, 51421105, 514171
Abstract:
Disclosed are compounds of Formula (I) wherein the R, R, R, R, X, Y, A, Q, E, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.
Renin Inhibitors
US Patent:
2010028, Nov 4, 2010
Filed:
Apr 4, 2008
Appl. No.:
12/450620
Inventors:
Jonh J. Baldwin - Gwyneed Valley PA, US
Salvacion Cacatian - Blue Bell PA, US
David Claremon - Maple Glen PA, US
Lawrence W. Dillard - Yardley PA, US
Patrick T. Flaherty - Pittsburgh PA, US
John Gleason - King of Prussia PA, US
Alexey V. Ishchenko - Somerville MA, US
Brian Lawhorn - King of Prussia PA, US
Gerard McGeehan - Garnet' Valley PA, US
Jaclyn R. Patterson - King of Prussia PA, US
Simon F. Semus - Collegeville PA, US
Robert D. Simpson - Wilmington DE, US
Suresh B. Singh - Kendall Park NJ, US
Colin Tice - Ambler PA, US
Tritin Tran - King of Prussia PA, US
Zhenrong Xu - Horsham PA, US
Jing Yuan - Lansdale PA, US
Wei Zhao - Eagleville PA, US
Salvacion Cacatian - Blue Bell PA, US
David Claremon - Maple Glen PA, US
Lawrence W. Dillard - Yardley PA, US
Patrick T. Flaherty - Pittsburgh PA, US
John Gleason - King of Prussia PA, US
Alexey V. Ishchenko - Somerville MA, US
Brian Lawhorn - King of Prussia PA, US
Gerard McGeehan - Garnet' Valley PA, US
Jaclyn R. Patterson - King of Prussia PA, US
Simon F. Semus - Collegeville PA, US
Robert D. Simpson - Wilmington DE, US
Suresh B. Singh - Kendall Park NJ, US
Colin Tice - Ambler PA, US
Tritin Tran - King of Prussia PA, US
Zhenrong Xu - Horsham PA, US
Jing Yuan - Lansdale PA, US
Wei Zhao - Eagleville PA, US
International Classification:
A61K 31/445
C07D 211/60
C07D 401/02
C07D 413/02
A61K 31/454
A61K 31/4545
A61K 31/4709
A61K 31/496
A61K 31/5377
A61K 31/5415
A61K 31/55
A61K 31/58
A61P 9/12
C07D 211/60
C07D 401/02
C07D 413/02
A61K 31/454
A61K 31/4545
A61K 31/4709
A61K 31/496
A61K 31/5377
A61K 31/5415
A61K 31/55
A61K 31/58
A61P 9/12
US Classification:
51421207, 546245, 546208, 546189, 546146, 544365, 544130, 514330, 514326, 514316, 514307, 51425313, 5142355, 5142235, 514171
Abstract:
Disclosed are compounds of Formula I, wherein the R, R, RR, X, Y, A, Q, E, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.
Renin Inhibitors
US Patent:
2010031, Dec 16, 2010
Filed:
Jun 20, 2008
Appl. No.:
12/665217
Inventors:
John J. Baldwin - Gwynedd Valley PA, US
Salvacion Cacatian - Blue Bell PA, US
David Claremon - Maple Glen PA, US
Lawrence W. Dillard - Yardley PA, US
Patrick T. Flaherty - Pittsburgh PA, US
Damiano Ghirlanda - Legnago, IT
Alexey V. Ishchenko - Somerville MA, US
Lara S. Kallander - King of Prussia PA, US
Brian Lawhorn - King of Prussia PA, US
Qing Lu - King of Prussia PA, US
Gerard McGeehan - Garnet Valley PA, US
Simon Semus - Collegeville PA, US
Robert D. Simpson - Wilmington DE, US
Suresh B. Singh - Kendall Park NJ, US
Lamont R. Terrell - King of Prussia PA, US
Colin Tice - Ambler PA, US
Tritin Tran - King of Prussia PA, US
Zherong Xu - Horsham PA, US
Jing Yuan - Lansdale PA, US
Wei Zhao - Eagleville PA, US
Yongdong Y. Zhao - King of Prussia PA, US
Salvacion Cacatian - Blue Bell PA, US
David Claremon - Maple Glen PA, US
Lawrence W. Dillard - Yardley PA, US
Patrick T. Flaherty - Pittsburgh PA, US
Damiano Ghirlanda - Legnago, IT
Alexey V. Ishchenko - Somerville MA, US
Lara S. Kallander - King of Prussia PA, US
Brian Lawhorn - King of Prussia PA, US
Qing Lu - King of Prussia PA, US
Gerard McGeehan - Garnet Valley PA, US
Simon Semus - Collegeville PA, US
Robert D. Simpson - Wilmington DE, US
Suresh B. Singh - Kendall Park NJ, US
Lamont R. Terrell - King of Prussia PA, US
Colin Tice - Ambler PA, US
Tritin Tran - King of Prussia PA, US
Zherong Xu - Horsham PA, US
Jing Yuan - Lansdale PA, US
Wei Zhao - Eagleville PA, US
Yongdong Y. Zhao - King of Prussia PA, US
International Classification:
A61K 31/445
C07D 211/06
C07D 211/06
US Classification:
514330, 546226
Abstract:
Disclosed are compounds having the formula (I): wherein the R, R, R, X, Y, A, L, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.
Quinazoline Compounds
US Patent:
2012022, Aug 30, 2012
Filed:
Nov 1, 2010
Appl. No.:
13/505324
Inventors:
Lara S. Kallander - King of Prussia PA, US
Brian Griffin Lawhorn - King of Prussia PA, US
Joanne Philp - King of Prussia PA, US
Brian Griffin Lawhorn - King of Prussia PA, US
Joanne Philp - King of Prussia PA, US
International Classification:
A61K 31/517
C12N 9/99
A61P 9/04
A61K 31/5377
C07D 491/056
A61K 31/519
C07D 239/94
C07D 295/12
C12N 9/99
A61P 9/04
A61K 31/5377
C07D 491/056
A61K 31/519
C07D 239/94
C07D 295/12
US Classification:
5142345, 544293, 5142664, 435184, 544119, 544250, 514267
Abstract:
Disclosed are compounds having the formula: wherein R, R, R, R, R, Rand Rare as defined herein, and methods of making and using the same.
Compounds And Methods
US Patent:
2012032, Dec 27, 2012
Filed:
Jan 11, 2011
Appl. No.:
13/520861
Inventors:
Lara S. Kallander - King of Prussia PA, US
Brian Griffin Lawhorn - King of Prussia PA, US
Joanne Philp - King of Prussia PA, US
Yongdong Zhao - King of Prussia PA, US
Brian Griffin Lawhorn - King of Prussia PA, US
Joanne Philp - King of Prussia PA, US
Yongdong Zhao - King of Prussia PA, US
International Classification:
A61K 31/506
C07D 413/12
A61K 31/5377
A61P 9/04
A61K 31/551
C07D 417/12
A61K 31/541
C07D 239/48
C07D 403/12
C07D 413/12
A61K 31/5377
A61P 9/04
A61K 31/551
C07D 417/12
A61K 31/541
C07D 239/48
C07D 403/12
US Classification:
514218, 544327, 514256, 544122, 5142358, 544295, 51425214, 544296, 540575, 544 584, 5142278
Abstract:
Disclosed are compounds having the formula:wherein R, R, R, R, R, and Rare as defined herein, and methods of making and using the same.
Renin Inhibitors
US Patent:
2009027, Nov 5, 2009
Filed:
Apr 5, 2007
Appl. No.:
12/225987
Inventors:
John J. Baldwin - Gwynedd Valley PA, US
David A. Claremon - Maple Glen PA, US
Colin M. Tice - Amber PA, US
Salvacion Cacatian - Blue Bell PA, US
Lawrence W. Dillard - Yardley PA, US
Alexey V. Ishchenko - Somerville MA, US
Jing Yuan - Landsdale PA, US
Zhenrong Xu - Horsham PA, US
Gerard McGeehan - Garnet Valley PA, US
Wei Zhao - Eagleville PA, US
Robert D. Simpson - Wilmington DE, US
Suresh B. Singh - Kendall park NJ, US
Patrick T. Flaherty - Pittsburgh PA, US
Lara S. Kallander - King of Prussia PA, US
Colin A. Leach - King of Prussia PA, US
Brian Lawhorn - King of Prussia PA, US
Qing Lu - King of Prussia PA, US
Lamont R. Terrell - King of Prussia PA, US
Jing Zhang - King of Prussia PA, US
Damiano Ghirlanda - King of Prussia PA, US
Xiaoping Hou - King of Prussia PA, US
Simon Semus - King of Prussia PA, US
David A. Claremon - Maple Glen PA, US
Colin M. Tice - Amber PA, US
Salvacion Cacatian - Blue Bell PA, US
Lawrence W. Dillard - Yardley PA, US
Alexey V. Ishchenko - Somerville MA, US
Jing Yuan - Landsdale PA, US
Zhenrong Xu - Horsham PA, US
Gerard McGeehan - Garnet Valley PA, US
Wei Zhao - Eagleville PA, US
Robert D. Simpson - Wilmington DE, US
Suresh B. Singh - Kendall park NJ, US
Patrick T. Flaherty - Pittsburgh PA, US
Lara S. Kallander - King of Prussia PA, US
Colin A. Leach - King of Prussia PA, US
Brian Lawhorn - King of Prussia PA, US
Qing Lu - King of Prussia PA, US
Lamont R. Terrell - King of Prussia PA, US
Jing Zhang - King of Prussia PA, US
Damiano Ghirlanda - King of Prussia PA, US
Xiaoping Hou - King of Prussia PA, US
Simon Semus - King of Prussia PA, US
International Classification:
A61K 31/5377
C07D 207/14
A61K 31/40
C07D 211/32
A61K 31/445
A61K 31/4545
C07D 401/10
C07D 413/06
A61P 9/12
C07D 207/14
A61K 31/40
C07D 211/32
A61K 31/445
A61K 31/4545
C07D 401/10
C07D 413/06
A61P 9/12
US Classification:
5142355, 548539, 514423, 546226, 514330, 514316, 546191, 544141
Abstract:
Disclosed are compounds according to Formula I:wherein the variables are defined herein. Such compounds are can bind aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity.Also described herein are methods of antagonizing aspartic protease inhibitors in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound according to Formula I.
Hydroxypyridoxazepines As Nrf2 Activators
US Patent:
2022020, Jun 30, 2022
Filed:
Feb 11, 2020
Appl. No.:
17/429088
Inventors:
- Brentford, Middlesex, GB
Michal Pawel GLOGOWSKI - Collegeville PA, US
Michael Clinton KOETTING - Collegeville PA, US
Brian Griffin LAWHORN - Collegeville PA, US
Jay M. MATTHEWS - Collegeville PA, US
Jaclyn Renee PATTERSON - Collegeville PA, US
Michal Pawel GLOGOWSKI - Collegeville PA, US
Michael Clinton KOETTING - Collegeville PA, US
Brian Griffin LAWHORN - Collegeville PA, US
Jay M. MATTHEWS - Collegeville PA, US
Jaclyn Renee PATTERSON - Collegeville PA, US
International Classification:
C07D 498/04
C07D 498/10
C07D 498/10
Abstract:
The present invention relates hydroxypyridoxazepine compounds, methods of making them, pharmaceutical compositions containing them and their use as Nrf2 activators. In particular, the invention relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, or a tautomer thereof, or a hydrate thereof.
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