Carl T Yamashiro, Age 66652 Aster Ct, Chandler, AZ 85248

2004022, Nov 18, 2004

Apr 1, 2002

10/114908

Buena Chui - Chandler AZ, US
Robert Elghanian - Skokie IL, US
Vineet Gupta - Reading MA, US
Krishnamurthy Jayaraman - Hoffman Estates IL, US
Gretchen Kiser - Mesa AZ, US
Changming Li - Schaumburg IL, US
Chang-Gong Liu - Cherry Hill NJ, US
Kenneth Luehrsen - Half Moon Bay CA, US
Abhijit Mazumder - Buffalo Grove IL, US
Ramesh Ramakrishnan - Vernon Hills IL, US
Todd Tuggle - Oceanside CA, US
Carl Yamashiro - Chandler AZ, US
Handy Yowanto - Walnut CA, US
Ekaterina Pestova - Downers Grove IL, US
David Fermin - Minneapolis MN, US
David Wang - Deerfield IL, US
Zhijie Gu - San Diego CA, US

C12Q001/68
G01N033/53
C12M001/34

435/006000, 435/007500, 435/287200

This invention relates to methods and compositions for determining single nucleotide polymorphisms (SNPs) in P450 genes. In preferred embodiments, self extension of interrogation probes is prevented by using novel non self-extension probes and/or methods, thereby improving the specificity and efficiency of P450 SNP detection in target samples with minimal false positive results. The invention thus describes a variety of methods to decrease self-extension of interrogation probes. In addition, this invention provides a unique collection of P450 SNP probes on one assay, primer sequences for specific amplification of each of the seven P450 genes and amplicon control probes to evaluate whether the intended p450 gene targets were amplified successfully. The invention also describes a variety of array platforms for performing the assays of the invention; for example: CodeLink™, eSensor™, multiplex arrays with cartridges etc., all described herein.

2010014, Jun 10, 2010

Aug 24, 2007

12/438944

Frederic Zenhausern - Fountain Hills AZ, US
Christine Orozco - Mystic CT, US
Mark Richards - Maricopa AZ, US
Carl Yamashiro - Chandler AZ, US
Sally A. Amundson - New York NY, US
Ralf Lenigk - Tempe AZ, US
Michael L. Bittner - Phoenix AZ, US
Yoganand Balagurunathan - Tempe AZ, US

C40B 60/12

506 39

Exposure to ionizing radiation can produce a well-defined dose dependent signature in terms of changes in gene expression. In approaches and devices described herein, such a signature can be used to generate and use a self-contained radiation biodosimeter device, based on, for example, a blood finger stick. Various aspects of the invention are directed to biodosimetry with a fully integrated biochip using gene expression signatures.