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Us Patents

High Performance Fragrance Formulation

US Patent:
2012024, Sep 27, 2012
Filed:
Mar 24, 2011
Appl. No.:
13/071244
Inventors:
Timothy Jay Young - Middletown NJ, US
Carlos Benaim - Bedford Hills NY, US
Judith L. Kerschner - Hawthorne NJ, US
Christophe Laudamiel - New York NY, US
International Classification:
A61K 8/34
A61Q 13/00
A61K 8/40
A61K 8/37
A61K 8/33
US Classification:
512 6, 512 1, 512 27, 512 26, 512 25, 512 21
Abstract:
A method of formulating a high performance fragrance formulation by selecting an effective amount of fragrance ingredients selected from the group consisting of aroma chemicals and essential oils defined according to the following algorithm:wherein P is equal to molecular polarizability, V is equal to molecular volume, A is equal to the molecular surface area. Ψ is a constant falling within the range {0.0025-0.0055} and Δ is a constant falling in the range of {−0.55 to −1.0} and the pair result in the above equality.

Method Of Causing The Reduction Of Physiological And/Or Subjective Reactivity To Stress In Humans Being Subjected To Stress Conditions

US Patent:
4671959, Jun 9, 1987
Filed:
May 2, 1986
Appl. No.:
6/858728
Inventors:
Craig B. Warren - Rumson NJ
Marina A. Munteanu - New York NY
Gary E. Schwartz - Guilford CT
Carlos Benaim - Hartsdale NY
Henry G. Walter - Mill Neck NY
Ronald S. Leight - Aberdeen NJ
Donald A. Withycombe - Lincroft NJ
Braja D. Mookherjee - Holmdel NJ
Robert W. Trenkle - Bricktown NJ
Assignee:
Yale University - New Haven CT
International Flavors & Fragrances Inc. - New York NY
International Classification:
A61K 3578
A61K 726
A61K 31335
US Classification:
4241951
Abstract:
Described is a method for reducing physiological and/or subjective reactivity to stress in humans being subjected to stress conditions. The method consists of administering to such humans an effective amount of a physiological and/or subjective stress reactivity-reducing substance selected from the group consisting of: (i) Nutmeg Oil; (ii) Mace Extract; (iii) Neroli Oil; (iv) Valerian Oil; (v) Myristicin; (vi) Isoelemicin; and (vii) Elemicin. Administration is through inhalation or transdermally using one or more of the above ingredients alone or in a suitable composition such as ethanol and/or a perfume composition, cologne or perfumed article (e. g. , air freshener or deodorant stick). Also described is a method for detecting the reduction of physiological and/or subjective reactivity to stress in a human.

Method Of Causing The Reduction Of Physiological And/Or Subjective Reactivity To Stress In Humans Being Subjected To Stress Conditions

US Patent:
4670264, Jun 2, 1987
Filed:
Nov 21, 1985
Appl. No.:
6/800428
Inventors:
Craig B. Warren - Rumson NJ
Marina A. Munteanu - New York NY
Gary E. Schwartz - Guilford CT
Carlos Benaim - Hartsdale NY
Henry G. Walter - Mill Neck NY
Ronald S. Leight - Aberdeen NJ
Donald A. Withycombe - Lincroft NJ
Braja D. Mookherjee - Holmdel NJ
Robert W. Trenkle - Bricktown NJ
Assignee:
International Flavors & Fragrances Inc. - New York NY
Yale University - New Haven CT
International Classification:
A61K 3578
A61K 726
A61K 31335
US Classification:
4241951
Abstract:
Described is a method for reducing physiological and/or subjective reactivity to stress in humans being subjected to stress conditions. The method consists of administering to such humans an effective amount of a physiological and/or subjective stress reactivity-reducing substance selected from the group consisting of: (i) Nutmeg Oil; (ii) Mace Extract; (iii) Neroli Oil; (iv) Valerian Oil; (v) Myristicin; (vi) Isoelemicin; and (vii) Elemicin. Administration is through inhalation or transdermally using one or more of the above ingredients alone or in a suitable composition such as ethanol and/or a perfume composition, cologne or perfumed article (e. g. , air freshener or deodorant stick). Also described is a method for detecting the reduction of physiological and/or subjective reactivity to stress in a human.

Adamantane Derivative, Compositions Of Matter Containing Same, Processes For Preparing Said Adamantane Derivative And Said Composition And Organoleptic And Deodorancy Used Of Said Adamantane Derivative And Said Composition

US Patent:
5041422, Aug 20, 1991
Filed:
Dec 28, 1990
Appl. No.:
7/635234
Inventors:
Anubhav Narula - Hazlet NJ
Carlos Benaim - Bedford Hills NY
International Classification:
A61K 746
US Classification:
512 19
Abstract:
Described are hydroxy adamantane compounds and derivatives thereof and a process for preparing same.

Substituted Cyclopentenyl-Oxabicyclooctanes, Cyclopentenyl-Formylcyclohexenes And Cyclopentenyl-Hydroxymethyl Cyclohexenes, Processes For Preparing Same And Organoleptic Uses Thereof

US Patent:
5070073, Dec 3, 1991
Filed:
Apr 11, 1991
Appl. No.:
7/684069
Inventors:
Anubhav P. S. Narula - Hazlet NJ
John J. De Virgilio - Freehold NJ
Carlos Benaim - Bedford Hills NY
Anton V. Ouwerkerk - Livingston NJ
Olivier Gillotin - Denville NJ
Assignee:
International Flavors & Fragrances Inc. - New York NY
International Classification:
A61K 746
US Classification:
512 13
Abstract:
Described are cyclopentenyl-oxabicyclooctanes, cyclopentenyl-formylcyclohexenes and cyclopentyl-hydroxymethyl cyclohexenes having the generic structures: ##STR1## wherein R. sub. 1, R. sub. 2, R. sub. 3 ', and R. sub. 3 " each represents hydrogen or methyl with the provisos: (i) one or two of R. sub. 1, R. sub. 2, R. sub. 3 ' and R. sub. 3 " represents methyl; (ii) R. sub. 1 and/or R. sub. 2 are methyl; (iii) at least one of R. sub. 3 ' and R. sub. 3 " is hydrogen; and (iv) when R. sub. 1 and R. sub. 2 is methyl then each of R. sub. 3 ' and R. sub. 3 " is hydrogen wherein R. sub. 4 ' is hydrogen or C. sub. 1 -C. sub. 5 alkyl, processes for preparing same and uses thereof in augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles, e. g. , solid or liquid, anionic, cationic, nonionic or zwitterionic detergents, cosmetic preparations, fabric softener compositions, fabric softener articles, hair preparations and perfumed polymers.

Novel Compounds, 4-(2,6,6-Trimethyl-1,3-Cyclohexadien-1-Yl)-2-Butanol And 4-(6,6-Dimethyl-2-Methylene-3-Cyclohexen-1-Yl)-2-Butanol

US Patent:
3996296, Dec 7, 1976
Filed:
Mar 24, 1975
Appl. No.:
5/561187
Inventors:
Braja Dulal Mookherjee - Matawan NJ
Manfred Hugo Vock - Locust NJ
Carlos Benaim - Hartsdale NY
Edward J. Shuster - Brooklyn NY
Assignee:
International Flavors & Fragrances Inc. - New York NY
International Classification:
C07C 3113
US Classification:
260617R
Abstract:
Described are the novel compounds, 4-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-2-butanol and 4-(6,6-dimethyl-2-methylene-3-cyclohexen-1-yl)-2-butanol, and processes for preparing the aforementioned alcohols and acetate esters thereof.

Camphonyl Spirocyclooxaoctane-Containing Compositions, Organoleptic Uses Thereof And Process For Preparing Same

US Patent:
5128317, Jul 7, 1992
Filed:
Jul 25, 1991
Appl. No.:
7/736283
Inventors:
Anubhav P. S. Narula - Hazlet NJ
John J. De Virgilio - Freehold NJ
Carlos Benaim - Bedford Hills NY
Anton Van Ouwerkerk - Livingston NJ
Olivier Gillotin - Denville NJ
Assignee:
International Flavors and Fragrances Inc. - New York NY
International Classification:
A61K 746
US Classification:
512 13
Abstract:
Described are camphonyl spirocyclooxaoctane-containing compositions having the generic structures: ##STR1## and mixtures of same with substituted cyclopentenyl-oxabicyclooctanes defined according to the generic structures: ##STR2## wherein R. sub. 1, R. sub. 2, R. sub. 3 ' and R. sub. 3 " each represents hydrogen or methyl and R. sub. 4 ' represents hydrogen or C. sub. 1 -C. sub. 5 alkyl, processes for preparing same and uses thereof in augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles, e. g. , solid or liquid anionic, cationic, nonionic or zwitterionic detergents, cosmetic preparations, fabric softener compositions, fabric softener articles, hair preparations and perfumed polymers.

Substituted Cyclopentenyl Oxabicyclooctanes, Cyclopentenylformylcyclohexenes And Cyclopentenylhydroxymethyl Cyclohexenes, Processes For Preparing Same And Organoleptic Uses Thereof

US Patent:
5081262, Jan 14, 1992
Filed:
Sep 27, 1990
Appl. No.:
7/588825
Inventors:
Anubhav P. S. Narula - Hazlet NJ
John J. De Virgilio - Freehold NJ
Carlos Benaim - Bedford Hills NY
Anton Van Ouwerkerk - Livingston NJ
Olivier Gillotin - Denville NJ
Assignee:
International Flavors & Fragrances Inc. - New York NY
International Classification:
C07C31306
US Classification:
549355
Abstract:
Described are cyclopentenyl-oxabicyclooctanes, cyclopentenyl-formylcyclohexenes and cyclopentyl-hydroxymethyl cyclohexenes having the generic structures: ##STR1## wherein R. sub. 1, R. sub. 2, R. sub. 3 ', and R. sub. 3 " each represents hydrogen or methyl with the provisos: (i) one or two of R. sub. 1, R. sub. 2, R. sub. 3 ' and R. sub. 3 " represents methyl; (ii) R. sub. 1 and/or R. sub. 2 are methyl; (iii) at least one of R. sub. 3 ' and R. sub. 3 " is hydrogen; and (iv) when R. sub. 1 and R. sub. 2 is methyl then each of R. sub. 3 ' and R. sub. 3 " is hydrogen wherein R. sub. 4 ' is hydrogen or C. sub. 1 -C. sub. 5 alkyl, processes for preparing same and uses thereof in augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles, e. g. , solid or liquid, anionic, cationic, nonionic or zwitterionic detergents, cosmetic preparations, fabric softener compositions, fabric softener articles, hair preparations and perfumed polymers.

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