Christopher Kenyon Welch, Age 43151 E Wilson St UNIT 406, Madison, WI 53703

6342160, Jan 29, 2002

Jan 8, 1999

09/226941

Christopher J. Welch - Glenview IL, 60025
Marina Protopopova - Chicago IL, 60601
Bhat Ganapati - Grayslake IL, 60030

B01D 1508

210635, 210656, 2101982, 436161

The invention discloses a method for rapid identification of a candidate selective separation material by placing small samples of the candidate material in an array of vials and adding a solution of the analytes to be separated. The solution is allowed to interact or equilibrate and the distribution of the analytes in the solid or liquid phase is measured usually by gas or liquid chromatography. The identified candidate material with the greatest differential adsorption of the analytes is selected and used as an adsorbent for large scale separation. The rapid screening of chromatographic adsorbents provides an efficient way of finding suitable absorbent materials for large scale separations.

5380873, Jan 10, 1995

Dec 22, 1992

7/999181

Christopher Bieniarz - Highland Park IL
Christopher Welch - Urbana IL

Abbott Laboratories - Abbott Park IL

C07D40312

548520

A coupling agent useful in conducting immunoassays, particularly assays for B12, is disclosed. The coupling agent has the formula ##STR1## Z and Z' can be the same or different and each is ##STR2## k, m and n are integers from 1 to 10, X is an alkylene group, a cycloalkylene group, an alkylcycloalkylene group, a bivalent aromatic group, or an aminoalkylene group, R and R' can be the same or different, and each is a substituted or unsubstituted aminoalkylene group having from 1 to 10 carbon atoms or a cycloalkylene or alkylcycloalkylene group having from 5 to 20 carbon atoms. Z and Z' are the same except that they can be the same or different when both are ##STR3## A method for purifying an aqueous intrinsic factor solution which contains R-protein is disclosed. The method involves adding to the intrinsic factor solution an amount of cobinamide sufficient to bind substantially all of the R-protein in the solution and an amount of an intrinsic factor affinity resin sufficient to bind the intrinsic factor in the solution, washing the bound cobinamide and the R-protein from the resin, eluting the intrinsic factor from the resin, and dialyzing the eluted intrinsic factor. The purified intrinsic factor can contain less than 0.

5104815, Apr 14, 1992

Jun 6, 1990

7/534381

William D. Garner - Lake Bluff IL
Lynn M. Codacovi - Antioch IL
Phillip G. Mattingly - Grayslake IL
Christopher J. Welch - Urbana IL
Steven C. Kuemmerle - Grayslake IL
Suzanne M. Delby - Kenosha WI
Theresa L. Lane - Evanston IL

Abbott Laboratories - Abbott Park IL

G01N 3382

436505

The current invention is a method, kit and reagents for detecting cobalamins in a sample. The method involves introducing into the sample a first conjugate of a latex or latex-like solid phase linked to affinity purified intrinsic factor with a first linking group at least three angstroms long. The first conjugate and the bound cobalamins in the sample are then exposed to a second conjugate of a cobalamin linked to a detectable enzyme to produce second conjugate bound to first conjugate and unbound second conjugate. The enzyme activity associated either with the solid phase first conjugate or the unbound second conjugate is then detected. By linking affinity purified intrinsic factor to a latex or latex-like solid phase with a first linking group at least three angstroms long, an exzyme assay can be performed which detects levels of cobalamins in patient samples within or below normal ranges found in such samples.

5002883, Mar 26, 1991

Oct 11, 1988

7/254288

Christopher Bieniarz - Highland Park IL
Christopher J. Welch - Urbana IL
Grady Barnes - Lindenhurst IL
Carol A. Schlesinger - Wheeling IL

Abbott Laboratories - Abbott Park IL

C12N 1106
C07K 1706

435176

Novel methods for covalent attachment of antibodies, antigens, or other molecules to solid phases using extended length heterobifunctional crosslinking reagents are disclosed. The resulting derivatized solid phases can be used in diagnostic assays.

5053520, Oct 1, 1991

Oct 1, 1989

7/402012

Christopher Bieniarz - Highland Park IL
Christopher J. Welch - Urbana IL
Grady Barnes - Lindenhurst IL

Abbott Laboratories - Abbott Park IL

C12N 1114
C07K 1706

548520

Novel polyamino acid based coupling agents are disclosed. These reagents are useful for conjugating proteins (e. g. antibodies to enzymes) for use in diagnostic assays.

4994385, Feb 19, 1991

Sep 22, 1988

7/246971

Christopher Bieniarz - Highland Park IL
Christopher J. Welch - Urbana IL
Grady Barnes - Lindenhurst IL

Abbott Laboratories - Abbott Park IL

C12N 1114
C07K 1706

435177

Novel polyamino acid based coupling agents are disclosed. These reagents are useful for conjugating proteins (e. g. antibodies to enzymes) for use in diagnostic assays.