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Dale T GruberBuffalo, NY

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Douglas Miller 66 Marian T Miller 69 Diane C Miller 61 Ameer Miller 41

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Buffalo, NY

Erie, PA

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Dale A Gruber

Licenses:
License #: 6024 - Expired
Category: Emergency Medical Care
Issued Date: Dec 31, 1995
Effective Date: Feb 4, 2008
Expiration Date: Dec 31, 2007
Type: EMT

Dale A Gruber

Licenses:
License #: 2333 - Expired
Category: Emergency Medical Care
Issued Date: Dec 31, 1995
Effective Date: Mar 8, 1999
Type: EMT A/D

Dale Gruber resumes & CV records

Resumes

Dale Gruber Photo 27

Confidential

Location:
Buffalo, NY
Industry:
Investment Banking
Work:
Confidential Business Sale, Inc.
Confidential
Dale Gruber Photo 28

Machist And Toolmaker And Moldmaker

Work:
Reitred
Machist and Toolmaker and Moldmaker
Dale Gruber Photo 29

Dale Gruber

Publications & IP owners

Us Patents

Serum-Free Mammalian Cell Culture Medium, And Uses Thereof

US Patent:
8198084, Jun 12, 2012
Filed:
Jun 14, 2005
Appl. No.:
11/151647
Inventors:
Stephen F. Gorfien - Williamsville NY, US
Richard M. Fike - Clarence NY, US
Glenn P. Godwin - North Tonawanda NY, US
Joyce L. Dzimian - Depew NY, US
David A. Epstein - East Amherst NY, US
Dale Gruber - East Amherst NY, US
Don McClure - Indianapolis IN, US
Paul J. Price - Grand Island NY, US
Assignee:
Life Technologies Corporation - Carlsbad CA
International Classification:
C12N 5/00
C12N 5/02
C12N 5/07
C12N 5/10
C12N 11/00
C12N 11/16
US Classification:
435358, 435174, 435383, 435389, 435404
Abstract:
The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.

Serum-Free Mammalian Cell Culture Medium, And Uses Thereof

US Patent:
8455246, Jun 4, 2013
Filed:
May 8, 2009
Appl. No.:
12/463351
Inventors:
Stephen Gorfien - Williamsville NY, US
Richard Fike - Clarence NY, US
Glenn Godwin - North Tonawanda NY, US
Joyce Dzimian - Lancaster NY, US
David A. Epstein - East Amherst NY, US
Dale Gruber - East Amherst NY, US
Paul Price - Grand Island NY, US
Assignee:
Life Technologies Corporation - Carlsbad CA
International Classification:
A61K 33/32
A61K 33/34
A01N 59/16
C12N 5/00
C12N 5/02
C12N 5/07
C12N 5/10
C12N 11/00
C12N 11/16
US Classification:
435325, 424641, 435174, 435358, 435383, 435389, 435404
Abstract:
The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.

Metal Binding Compounds And Their Use In Cell Culture Medium Compositions

US Patent:
2004021, Oct 28, 2004
Filed:
May 26, 2004
Appl. No.:
10/853697
Inventors:
David Epstein - East Amherst NY, US
Paul Battista - Eggertsville NY, US
Dale Gruber - East Amherst NY, US
David Judd - Williamsville NY, US
International Classification:
C12N005/02
US Classification:
435/404000
Abstract:
The present invention is directed generally to metal binding compounds which may be added to cell culture media to replace factors required for cultivation of the cells (e.g. transferrin) which are of animal or human origin. More specifically, the invention is directed to metal binding compounds or complexes thereof comprising one or more transition element cations (such as ferrous or ferric ions), which are added to cell and tissue culture medium compositions. The metal binding compounds may be added to the media alone or may be first complexed with a transition metal ion. The invention is also directed to methods of use of such compositions, including, for example, methods for the cultivation of eukaryotic cells, particularly animal cells, in vitro. The invention also relates to compositions comprising such culture media and one or more cells, and to kits comprising one or more of the above-described compositions. The compositions of the present invention obviate the need for naturally derived metal-binding proteins, such as transferrin and ceruloplasmin, which may contain blood-borne pathogens.

Metal Binding Compounds And Their Use In Cell Culture Medium Compositions

US Patent:
2008028, Nov 20, 2008
Filed:
Jun 9, 2008
Appl. No.:
12/135926
Inventors:
David A. Epstein - East Amherst NY, US
Paul J. Battista - Eggertsville NY, US
Dale F. Gruber - East Amherst NY, US
David A. Judd - Williamsville NY, US
Assignee:
INVITROGEN CORPORATION - Carlsbad CA
International Classification:
C12N 5/02
US Classification:
435404
Abstract:
The present invention is directed generally to metal binding compounds which may be added to cell culture media to replace factors required for cultivation of the cells (e.g. transferrin) which are of animal or human origin. More specifically, the invention is directed to metal binding compounds or complexes thereof comprising one or more transition element cations (such as ferrous or ferric ions), which are added to cell and tissue culture medium compositions. The metal binding compounds may be added to the media alone or may be first complexed with a transition metal ion. The invention is also directed to methods of use of such compositions, including, for example, methods for the cultivation of eukaryotic cells, particularly animal cells, in vitro. The invention also relates to compositions comprising such culture media and one or more cells, and to kits comprising one or more of the above-described compositions. The compositions of the present invention obviate the need for naturally derived metal-binding proteins, such as transferrin and ceruloplasmin, which may contain blood-borne pathogens.

Metal Binding Compounds And Their Use In Cell Culture Medium Compositions

US Patent:
2011018, Jul 28, 2011
Filed:
Jan 25, 2011
Appl. No.:
13/013629
Inventors:
David A. Epstein - East Amherst NY, US
Paul J. Battista - Eggertsville NY, US
Dale F. Gruber - Leesburg FL, US
David A. Judd - Grand Island NY, US
Assignee:
LIFE TECHNOLOGIES CORPORATION - Carlsbad CA
International Classification:
C12P 21/00
C12N 5/02
C12N 1/00
C12N 5/04
C12N 5/071
C12N 5/07
C12N 7/00
US Classification:
435 691, 435404, 435243, 435431, 435349, 435348, 435358, 435365, 435369, 435364, 435325, 435366, 4352351
Abstract:
The present invention is directed generally to metal binding compounds which may be added to cell culture media to replace factors required for cultivation of the cells (e.g. transferrin) which are of animal or human origin. More specifically, the invention is directed to metal binding compounds or complexes thereof comprising one or more transition element cations (such as ferrous or ferric ions), which are added to cell and tissue culture medium compositions. The metal binding compounds may be added to the media alone or may be first complexed with a transition metal ion. The invention is also directed to methods of use of such compositions, including, for example, methods for the cultivation of eukaryotic cells, particularly animal cells, in vitro. The invention also relates to compositions comprising such culture media and one or more cells, and to kits comprising one or more of the above-described compositions. The compositions of the present invention obviate the need for naturally derived metal-binding proteins, such as transferrin and ceruloplasmin, which may contain blood-borne pathogens.

Serum-Free Mammalian Cell Culture Medium, And Uses Thereof

US Patent:
2013006, Mar 14, 2013
Filed:
Sep 10, 2012
Appl. No.:
13/608803
Inventors:
Stephen F. GORFIEN - Williamsville NY, US
Richard M. Fike - Clarence NY, US
Glenn P. Godwin - Holbrook MA, US
Joyce L. Dzimian - Lancaster NY, US
David A. Epstein - East Amherst NY, US
Dale Gruber - Leesburg FL, US
Don McClure - Indianapolis IN, US
Paul J. Price - Mount Pleasant SC, US
Assignee:
LIFE TECHNOLOGIES CORPORATION - Carlsbad CA
International Classification:
C12N 5/075
C12N 7/00
C07K 2/00
C12P 21/00
US Classification:
435 691, 435358, 4352351, 530300
Abstract:
The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.

Serum-Free Mammalian Cell Culture Medium, And Uses Thereof

US Patent:
2013029, Nov 7, 2013
Filed:
Mar 20, 2013
Appl. No.:
13/847961
Inventors:
Richard Fike - Clarence NY, US
Glenn Godwin - Holbrook MA, US
Joyce Dzimian - Lancaster NY, US
David Epstein - East Amherst NY, US
Dale Gruber - Leesburg FL, US
Paul Price - Mount Pleasant SC, US
International Classification:
C12N 5/071
C12N 5/073
US Classification:
435358
Abstract:
The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.

Metal Binding Compounds And Their Use In Cell Culture Medium Compositions

US Patent:
6767741, Jul 27, 2004
Filed:
Aug 28, 2000
Appl. No.:
09/650339
Inventors:
David A. Epstein - East Amherst NY
Paul J. Battista - Eggertsville NY
Dale F. Gruber - Grand Island NY
David A. Judd - Williamsville NY
Assignee:
Invitrogen Corporation - Carlsbad CA
International Classification:
C12N 500
US Classification:
435404, 435405
Abstract:
The present invention is directed generally to metal binding compounds which may be added to cell culture media to replace factors required for cultivation of the cells (e. g. transferrin) which are of animal or human origin. More specifically, the invention is directed to metal binding compounds or complexes thereof comprising one or more transition element cations (such as ferrous or ferric ions), which are added to cell and tissue culture medium compositions. The metal binding compounds may be added to the media alone or may be first complexed with a transition metal ion. The invention is also directed to methods of use of such compositions, including, for example, methods for the cultivation of eukaryotic cells, particularly animal cells, in vitro. The invention also relates to compositions comprising such culture media and one or more cells, and to kits comprising one or more of the above-describcd compositions. The compositions of the present invention obviate the need for naturally derived metal-binding proteins, such as transferrin and ceruloplasmin, which may contain blood-borne pathogens.

Possible Relatives

David P Gruber  Dawn M Gruber  Deborah A Gruber  Debra S Gruber  Aaron M Gruber  Dennis D Gruber  Darin R Gruber  Dale Johnson  Dale W Standard  Dale D Standley 

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