Daniel O Chiu15523 Lakewood Blvd, Paramount, CA 90723

6705357, Mar 16, 2004

Sep 18, 2001

09/954710

Noo Li Jeon - Irvine CA
Stephan K. W. Dertinger - Cambridge MA
Daniel T. Chiu - Seattle WA
Insung S. Choi - Cambridge MA
George M. Whitesides - Newton MA

President and Fellows of Harvard College - Cambridge MA

B65B 300

141 9, 141100, 141236, 141240, 141286, 222132

A method and apparatus for treating a fluid. A method for treating a fluid may include combining two or more separate streams into a common stream and then splitting the common stream into a new set of separate streams wherein the separate streams may possess different properties. The separate streams may be combined to produce a gradient, such as a concentration gradient or shear gradient. The apparatus of the invention may provide a network of fluidic channels that may be used to manipulate a fluid to produce, for example, a gradient or a series of solutions containing a substance at varying concentrations.

6767194, Jul 27, 2004

Jan 8, 2002

10/041718

Noo Li Jeon - Irvine CA
Daniel T. Chiu - Seattle WA
Christopher J. Wargo - Highland Park NJ
Insung S. Choi - Cambridge MA
Hongkai Wu - Somerville MA
Janelle R. Anderson - Toronto, CA
George M. Whitesides - Newton MA
Justin C. McDonald - Cambridge MA
Steven J. Metallo - Arlington VA
Howard A. Stone - Cambridge MA

President and Fellows of Harvard College - Cambridge MA

F04B 5310

417559, 435 6, 536 221, 204601, 25112914

The present invention relates to microfluidic systems, including valves and pumps for microfluidic systems. The valves of the invention include check valves such as diaphragm valves and flap valves. Other valves of the invention include one-use valves. The pumps of the present invention include a reservoir and at least two check valves. The reservoir may be of variable volume. The present invention also relates to a flexible microfluidic system. The present invention additionally relates to a method of making microfluidic systems including those of the present invention. The method includes forming a microfluidic system on a master, connecting a support to the microfluidic system and removing the microfluidic system from the master. The support may remain connected to the microfluidic system or the microfluidic system may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system.

6883559, Apr 26, 2005

Oct 21, 2003

10/690475

Noo Li Jeon - Irvine CA, US
Stephan K. W. Dertinger - Munich, DE
Daniel T. Chiu - Seattle WA, US
Insung S. Choi - Daejeon, KR
George M. Whitesides - Newton MA, US

President and Fellows of Harvard College - Cambridge MA

B65B003/00

141 9, 141100, 141236, 141240, 141286, 222132

A method and apparatus for treating a fluid. A method for treating a fluid may include combining two or more separate streams into a common stream and then splitting the common stream into a new set of separate streams wherein the separate streams may possess different properties. The separate streams may be combined to produce a gradient, such as a concentration gradient or shear gradient. The apparatus of the invention may provide a network of fluidic channels that may be used to manipulate a fluid to produce, for example, a gradient or a series of solutions containing a substance at varying concentrations.

7314070, Jan 1, 2008

Jan 18, 2005

11/037459

Noo Li Jeon - Irvine CA, US
Stephan K. W. Dertinger - Munich, DE
Daniel T. Chiu - Seattle WA, US
Insung S. Choi - Daejeon, KR
George M. Whitesides - Newton MA, US

President and Fellows of Harvard College - Cambridge MA

B65B 3/00

141100, 141 9, 141236, 141240, 141286, 222132

A method and apparatus for treating a fluid. A method for treating a fluid may include combining two or more separate streams into a common stream and then splitting the common stream into a new set of separate streams wherein the separate streams may possess different properties. The separate streams may be combined to produce a gradient, such as a concentration gradient or shear gradient. The apparatus of the invention may provide a network of fluidic channels that may be used to manipulate a fluid to produce, for example, a gradient or a series of solutions containing a substance at varying concentrations.

7942160, May 17, 2011

Jun 14, 2004

10/867151

Noo Li Jeon - Irvine CA, US
Daniel T. Chiu - Seattle WA, US
Christopher J. Wargo - Highland Park NJ, US
Insung S. Choi - Yuseong-gu, KR
Hongkai Wu - Palo Alto CA, US
Janelle R. Anderson - Toronto, CA
George M. Whitesides - Newton MA, US
J. Cooper McDonald - Somerville MA, US
Steven J. Metallo - Silver Spring MD, US
Howard A. Stone - Brookline MA, US

President and Fellows of Harvard College - Cambidge MA

F16K 15/03
F16K 15/04

137 1519, 137613, 137859, 13753311, 137855

The present invention relates to microfluidic systems, including valves and pumps for microfluidic systems. The valves of the invention include check valves such as diaphragm valves and flap valves. Other valves of the invention include one-use valves. The pumps of the present invention include a reservoir and at least two check valves. The reservoir may be of variable volume. The present invention also relates to a flexible microfluidic system. The present invention additionally relates to a method of making microfluidic systems including those of the present invention. The method includes forming a microfluidic system on a master, connecting a support to the microfluidic system and removing the microfluidic system from the master. The support may remain connected to the microfluidic system or the microfluidic system may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system.

2009022, Sep 10, 2009

Dec 23, 2008

12/317556

Michael A. Hill - Santa Monica CA, US
Ulrich Rankers - Livermore CA, US
Sheldon B. Moberg - Thousand Oaks CA, US
Daniel Chan Chiu - Los Angeles CA, US

MEDTRONIC MINIMED, INC. - Northridge CA

A61B 5/157
A61M 5/14
G08B 23/00
G06F 3/048
G05D 7/06
G09F 13/04
H05B 41/36

600365, 604151, 3405731, 715867, 700282, 362 971, 315150

An infusion system that includes a controller device and a communication system to provide for two-way communication between the controller device and an infusion device that controls delivery of fluids to a user's body. Either the controller device or the infusion device may be integrated with a characteristic determining device in a single housing. The housing, in turn, may include a test-strip receptacle and an illuminator disposed so as to illuminate an area covering the receptacle and a test-strip inserted therein. The illuminator may be configured to be activated automatically when a test strip is inserted into the receptacle, selectively by the user via a button, key, or similar mechanism, and/or when the ambient light level, measured, e.g., with a light sensor, falls below a predetermined intensity. The illuminator may be a LED emitting white light, and may provide illumination at various levels of intensity.

2012001, Jan 12, 2012

Sep 20, 2011

13/237558

MICHAEL A. HILL - Santa Monica CA, US
Ulrich Rankers - Livermore CA, US
Sheldon B. Moberg - Thousand Oaks CA, US
Daniel Chan Chiu - Los Angeles CA, US

MEDTRONIC MINIMED, INC. - Northridge CA

A61M 5/168

604 66

An infusion system that includes a controller device and a communication system to provide for two-way communication between the controller device and an infusion device that controls delivery of fluids to a user's body. Either the controller device or the infusion device may be integrated with a characteristic determining device in a single housing. The housing, in turn, may include a test-strip receptacle and an illuminator disposed so as to illuminate an area covering the receptacle and a test-strip inserted therein. The illuminator may be configured to be activated automatically when a test strip is inserted into the receptacle, selectively by the user via a button, key, or similar mechanism, and/or when the ambient light level, measured, e.g., with a light sensor, falls below a predetermined intensity. The illuminator may be a LED emitting white light, and may provide illumination at various levels of intensity.