Daniel Kagan, Age 6198 Davos Pt, Woodridge, NY 12789

7030102, Apr 18, 2006

Dec 30, 2003

10/748096

Doddabele L. Madhavi - Worcester MA, US
Daniel I. Kagan - Belmont MA, US

BioActives, LLC - Belmont MA

A61K 31/715

514 58, 424435, 424451, 424489

The present invention is based on the unexpected discovery that CoQ-10 can be made commercially in a highly bioavailable form suitable for topical, sublingual formulations, or for oral ingestion. One such bioavailable form is a water dispersible freeze-dried CoQ-10/γ-cyclodextrin complex. Complexation in general with γ- or α-cyclodextrin improved the cellular uptake of CoQ-10 as compared to water dispersible liposomal or micellar forms of CoQ-10. Thus, the present invention includes a highly bioavailable CoQ-10/cyclodextrin complex for use in the nutritional supplement, oral care, and pharmaceutical industry.

7297803, Nov 20, 2007

Feb 6, 2006

11/348141

Doddabele L. Madhavi - Worcester MA, US
Daniel I. Kagan - Belmont MA, US

BioActives, LLC - Belmont MA

C07C 233/00

554 12

A method for concentrating trans-lutein esters from marigold oleoresin, which includes blending the oleoresin with a solvent and a co-solvent of lower alkanols and recovering a precipitate enriched with trans-lutein esters at a temperature of above 22 C. The recovery of the trans-lutein esters is greater using the alkanol blend than when using only a lower alkanol in the said blend. The process is most useful using a lower-grade, commercially available oleoresin, thereby helping small producers, who do not have access to higher-grade oleoresin made through backward integration to marigold cultivation and harvest.

7390914, Jun 24, 2008

Jan 30, 2006

11/344375

Doddabele L. Madhavi - Worcester MA, US
Daniel I. Kagan - Belmont MA, US

BioActives, LLC - Belmont MA

C07C 1/00

554 12

A method for concentrating trans-xanthophyll esters from marigold oleoresin, which includes blending the oleoresin with a solvent and a co-solvent of lower alkanols and recovering a precipitate enriched with trans-xanthophyll esters at a temperature of above 22 C. The recovery of the trans-xanthophyll esters is greater when using the alkanol blend than when using only a lower alkanol from the said blend. The said process is most useful using a lower-grade, commercially available oleoresin, thereby helping small producers, who do not have access to higher-grade oleoresin made through backward integration to marigold cultivation and harvest.

7446101, Nov 4, 2008

Dec 12, 2003

10/735335

Doddabele L. Madhavi - Worcester MA, US
Daniel I. Kagan - Belmont MA, US

Bioactives, LLC - Belmont MA

A61K 31/047
A61K 31/724

514 58, 514738

The present invention describes an improved commercial process for the production of carotenoid-cyclodextrin complexes and formulation of the complex for human ingestion. Complexation with cyclodextrins (e. g. , α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, or HP-β-cyclodextrin) significantly improves the uptake of carotenoids (e. g. , lycopene, lutein, or zeaxanthin) and their mixtures in vitro. The method for making such complexes includes forming a carotenoid/cyclodextrin complex; freezing drying said carotenoid/cyclodextrin complex; and blending said freeze-dried carotenoid/cyclodextrin complex with a mixture of lecithin and a vegetable oil or a vegetable oil suitable for soft gelatin capsules. The cyclodextrin/carotenoid complex can be formed in a molar ratio of between about 0. 5:1. 0 and 10:1.

8435967, May 7, 2013

Dec 1, 2010

12/957525

Doddabele L. Madhavi - Worcester MA, US
Daniel I. Kagan - Belmont MA, US

Bio-Actives LLC - Worcester MA

A61K 31/724
A61K 31/045

514 58, 514724, 426648

Disclosed is a formulation of policosanol with natural cyclodextrins resulting in a water dispersible form of policosanol. The disclosed process provides an economical commercial method for making the policosanol complex. The complex is suitable for incorporation into oral dosage forms and also in functional foods. One aspect of the present disclosure is a process for making a water dispersible policosanol cyclodextrin complex for animal ingestion. This method includes preparing a policosanol cyclodextrin complex and administering said complex to an animal. The preferred animal is a human with the route of administration being oral ingestion. The form of the complex for ingestion can be a hard gelatin capsule, tablet or wafers, which may contain other ingredients, both active and inactive. The complex also can be further formulated with excipients suitable for soft gelatin capsules, such as, for example, vegetable oils, waxes, lecithin, and surfactants such as Tween-80.

2006002, Feb 2, 2006

Jul 26, 2005

11/190094

Doddabele Madhavi - Worcester MA, US
Daniel Kagan - Belmont MA, US

A61K 9/68
A61K 8/66

424049000, 424048000

The present invention incorporates of a highly bioavailable coenzyme Q-10/cyclodextrin inclusion complex into oral care products, such as, toothpaste, mouth wash, chewing gum, breath mint, mouth spray, gels, and lozenges. The inclusion complex also is suitable for devices, such as dental loops, for delivering coenzyme Q-10 to the periodontum by direct physical contact. The inclusion complex is water dispersible or water soluble, stable in the presence of components of the formulation, and is highly bioavailable to the cells in the oral cavity.

2008021, Sep 4, 2008

Feb 15, 2008

12/070195

Doddabele L. Madhavi - Worcester MA, US
Daniel I. Kagan - Belmont MA, US

BioActives, LLC - Belmont MA

A61K 31/724

514 58

Disclosed is a formulation of policosanol with natural cyclodextrins resulting in a water dispersible form of policosanol. The disclosed process provides an economical commercial method for making the policosanol complex. The complex is suitable for incorporation into oral dosage forms and also in functional foods. One aspect of the present disclosure is a process for making a water dispersible policosanol cyclodextrin complex for animal ingestion. This method includes preparing a policosanol cyclodextrin complex and administering said complex to an animal. The preferred animal is a human with the route of administration being oral ingestion. The form of the complex for ingestion can be a hard gelatin capsule, tablet or wafers, which may contain other ingredients, both active and inactive. The complex also can be further formulated with excipients suitable for soft gelatin capsules, such as, for example, vegetable oils, waxes, lecithin, and surfactants such as Tween-80.

6380442, Apr 30, 2002

Oct 10, 2001

09/974141

Doddabele L. Madhavi - Worcester MA
Daniel I. Kagan - Belmont MA

BioActives, LLC - Belmont MA

C07C 3521

568816

A practical and effective process for isolating and purifying mixed carotenoids containing higher concentrations of specific compounds, such as all-trans lutein, without the use of harmful organic solvents, is disclosed. The process employs hydrolysis of carotenoid esters in a mixture of isopropanol, water, and alkali to separate the carotenoids from other impurities. The carotenoids are purified further using aqueous precipitation, followed by centrifugation and drying under vacuum. The product is a fine crystalline powder with very low residual solvents (hexane 0. 22 ppm; isopropanol 0. 53 ppm) suitable for human consumption, either in nutritional supplements or as a food additive.