Daniel James Kenan, Age 65Charlottesville, VA

7531505, May 12, 2009

Jan 5, 2007

11/649935

Paul Theodore Hamilton - Cary NC, US
Daniel James Kenan - Chapel Hill NC, US
Amy Katherine Solan - Durham NC, US

Affinergy, Inc. - Durham NC

A61K 38/00
A61F 2/04

514 2, 623 115, 424423

The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a metallic surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a metallic surface of a medical device, and for manufacturing of a medical device, comprise contacting the metallic surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.

7608581, Oct 27, 2009

Dec 14, 2006

11/638973

Paul Hamilton - Cary NC, US
Daniel Kenan - Chapel Hill NC, US
Mark Grinstaff - Boston MA, US

Affinergy, Inc. - Durham NC

C07K 14/00

514 2, 530300, 530350

The present invention provides compositions and methods for an improved coating for medical devices. Provided is an interfacial biomaterial or biofunctional coating composition comprising at least one binding domain that has bind specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for an antimicrobial composition. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating.

7807624, Oct 5, 2010

Jan 5, 2007

11/649950

Daniel James Kenan - Chapel Hill NC, US
Paul Theodore Hamilton - Cary NC, US

Affinergy, Inc. - Durham NC

C07K 14/00

514 2, 514 12, 530350, 530300

The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.

2003018, Oct 2, 2003

Nov 20, 2002

10/300694

Mark Grinstaff - Durham NC, US
Daniel Kenan - Chapel Hill NC, US
Elisabeth Walsh - Durham NC, US
Crystan Middleton - Arlington VA, US

C07K007/08
A61F002/00

424/423000, 530/326000

An interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a first ligand that specifically binds a non-biological substrate and a second ligand that specifically binds a biological substrate. Also provided is an interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a ligand that specifically binds a non-biological substrate and a non-binding domain that shows substantially no binding to a biological substrate. Also provided are methods for preparing a binding agent, methods for preparing an interfacial biomaterial, and methods for using interfacial biomaterials.

2003022, Dec 4, 2003

Apr 16, 2003

10/417393

Jack Keene - Durham NC, US
Daniel Kenan - Durham NC, US
Donald Tsai - Durham NC, US

A61K048/00
C12Q001/68
C12Q001/70
A61K039/395

514/044000, 435/005000, 435/006000, 424/130100

A method of generating a nucleic acid species which are immunologically cross-reactive with non-nucleic acid immunogens is disclosed. The method comprises combining an antigen binding protein which binds said immunogen with a degenerate pool of nucleic acid species, and then recovering a nucleic acid species bound by said antigen binding protein from said degenerate pool. Also disclosed are the nucleic acid species so made, along with the use thereof for tagging molecules for immunological detection, for detecting antibodies to predetermined non-nucleic acid immunogens, for blocking complex formation between an antigen binding protein and a non-nucleic acid immunogen, and for inducing an immune response to the immunogen in a human or animal subject. Preferred immunogens are peptides and preferred antigen binding proteins are antibodies.

2006005, Mar 9, 2006

Jun 15, 2005

11/153143

Paul Hamilton - Cary NC, US
Mark Grinstaff - Brookline MA, US
Daniel Kenan - Chapel Hill NC, US
Dale Christensen - Cary NC, US

Affinergy, Inc. - Research Triangle Park NC

A61K 38/16
A61K 38/05
A61F 2/00

424423000, 514002000

The present invention provides compositions and methods for an improved coating for medical devices. The coating is an interfacial biomaterial (“IFBM”) which comprises at least one binding module that binds to the surface of a device (“surface-binding module”) and at least one binding module that performs another function (“affector module”) and which acts to inhibit biofilm formation.

2006021, Sep 28, 2006

Jan 10, 2006

11/329292

Mark Grinstaff - Durham NC, US
Daniel Kenan - Chapel Hill NC, US
Elisabeth Walsh - Durham NC, US
Crystan Middleton - Arlington VA, US

G01N 33/558
C07K 7/08
C07K 7/06

435007930, 436514000, 530326000, 530327000, 530328000

An interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a first ligand that specifically binds a non-biological substrate and a second ligand that specifically binds a biological substrate. Also provided is an interfacial biomaterial prepared using a plurality of binding agents, each binding agent including a ligand that specifically binds a non-biological substrate and a non-binding domain that shows substantially no binding to a biological substrate. Also provided are methods for preparing a binding agent, methods for preparing an interfacial biomaterial, and methods for using interfacial biomaterials.

2006023, Oct 19, 2006

Apr 13, 2005

11/105202

Daniel Kenan - Chapel Hill NC, US
Dale Christensen - Cary NC, US
Mark Grinstaff - Brookline MA, US

Affinergy, Inc. - Research Triangle Park NC

C12Q 1/70
G01N 33/53

435005000, 422101000, 435287100, 436177000, 435007100, 210615000, 210406000

A filter and method for removing selected materials from a biological fluid sample are provided. The filter comprises an outer housing, inlet, and outlet. A plurality of filter surfaces are provided within the outer housing, and at least one coating is applied to the filter surfaces. The at least one coating comprises at least two binding modules that are in turn selectively bound to one another. One binding module is selectively bound to the filter surfaces and another binding module is configured to bind selectively to the selected materials that are to be removed from the fluid sample. As the fluid sample is allowed to pass through the inlet, outer housing, and outlet, the selected materials are selectively bound to the filter surfaces via the coating, thus producing a filtered product at the outlet.