David A Atwood, Age 592133 Leafland Pl, Lexington, KY 40515

6586600, Jul 1, 2003

Dec 6, 2000

09/730622

David A. Atwood - Lexington KY
Brock S. Howerton - Lexington KY
Matthew Matlock - Lexington KY

University of Kentucky Research Foundation - Lexington KY

C07D21346

546323, 564156, 546 6, 210638, 210688

Novel sulfur-containing ligands for binding of heavy metals are disclosed. The ligands incorporate a central ring structure and pendant alkyl-thiol chains. The ligands are of the general structure: where n is an integer from 1-4, and X is selected from the group consisting of hydrogen, lithium, sodium, potassium, rubidium, cesium, and francium. The ligands of the present invention are suitable for binding any metal in or capable of being placed in a positive oxidation state, such as cadmium, lead, nickel, zinc, mercury, copper, and the like. Additionally, methods for removal of heavy metals from various substances are disclosed, comprising separating selected heavy metals from selected substances by contacting the substances with an effective amount of the novel sulfur-containing chelate ligands for a sufficient time to form stable, irreversible ligand-metal precipitates, and removing such precipitates.

6852369, Feb 8, 2005

Sep 5, 2003

10/656569

David Allan Atwood - Lexington KY, US

University of Kentucky Research Foundation - Lexington KY

B05D001/18

427435, 427421, 4274301, 148271, 148243

Methods for preventing dissolution of solid substrates, such as metal leaching from coal or corrosion of metal surfaces, are provided. The method comprises coating the solid substrate with a chelate ligand having the general structure: where n is an integer from 1-4, and X is selected from the group consisting of hydrogen, lithium, sodium, potassium, rubidium, cesium, and francium. A method for preventing metal leaching from coal, such as acid mine drainage or metal leachate in runoff from coal refuse piles, is also provided.

7105703, Sep 12, 2006

Jun 23, 2005

11/166936

David A. Atwood - Lexington KY, US

University of Kentucky Research Foundation - Lexington KY

C07F 9/02
C07F 5/00
B01J 31/00

568 8, 556 32, 502167

A novel chemical compound has a general formula (LX)Y wherein X is selected from a group consisting of a group 13 element other than boron, Y is selected from a group consisting of a halide, a chlorate, a sulfate and a nitrate and L is a chelating ligand containing two nitrogen and two oxygen donor groups where n=1 or 2.

7166591, Jan 23, 2007

Feb 9, 2004

10/774619

David Allan Atwood - Lexington KY, US

University of Kentucky Research Foundation - Lexington KY

A61K 31/555
C07F /00

5142305, 544 69, 549 4

Novel chemical compounds are disclosed having the general formula L{YX}, wherein X is selected from the Group 13 elements, Y is a halide, and L is a chelating ligand containing at least one binding atom contacting the Group 13 element, the atom being selected from the group consisting of C, N, O, and S, and m and n are integers having a value of at least 1. L may be a Schiff base type ligand, such as a salen ligand. The compositions of the present invention may be bidentate, quadridentate, or greater. The compositions may be used in dealkylation of phosphate esters or ethers. Advantageously, the methods of the present invention may be rendered catalytic.

7419604, Sep 2, 2008

Dec 29, 2005

11/321488

David A. Atwood - Lexington KY, US

University of Kentucky Research Foundation - Lexington KY

C02F 1/62
C02F 101/20

210725, 210724, 210727, 210912, 423 11

A method is provided for removing uranium from water. The method includes the mixing of a boron reagent with water contaminated with uranyl dication ions, leading to removal of the uranium from that water.

8575218, Nov 5, 2013

Mar 7, 2011

13/041798

Boyd E. Haley - Nicholasville KY, US
David A. Atwood - Lexington KY, US
Niladri Gupta - Georgetown KY, US

The University of Kentucky Research Foundation - Lexington KY

A01N 37/12
A01N 37/10
A01N 43/00

514562, 514568, 514183

Methods and pharmaceutical formulations for ameliorating heavy metal toxicity and/or oxidative stress are disclosed, comprising administering pharmaceutically effective amounts of ligands according to the present disclosure. The ligands are of the general structure:.

2011007, Mar 31, 2011

Sep 28, 2010

12/892464

Boyd E. Haley - Nicholasville KY, US
David A. Atwood - Lexington KY, US

A61K 31/795
C07C 323/59
C07K 5/083
C08F 8/34
C07F 7/02
A61K 31/695
A61K 38/06
A61K 31/216
A61K 31/198
A61P 43/00
B01D 53/64

424 7827, 562426, 560 16, 530331, 5253335, 556419, 514 63, 514 219, 514533, 514562, 423210

Sulfur-containing ligands and methods of their utilization for binding metals and/or main group elements and removing them from fluids, solids, gases and/or tissues are disclosed. The ligands are of the general structure:where Rcomprises benzene, pyridine, pyridin-4-one, naphthalene, anthracene, phenanthrene or alkyl groups, Rcomprises hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, organic groups or biological groups, Rcomprises alkyls, aryls, a carboxyl group, carboxylate esters, organic groups or biological groups, X comprises hydrogen, lithium, sodium, potassium, rubidium, cesium, francium, alkyls, aryls, a carboxyl group, carboxylate esters, thiophosphate, N-acetyl cysteine, mercaptoacetic acid, mercaptopropionic acid, thiolsalicylate, organic groups or biological groups, n independently equals 1-10, m=1-6, Y comprises hydrogen, polymers, silicas or silica supported substrates, and Z comprises hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, a hydroxyl group, NH, HSO, halogens, a carbonyl group, organic groups, biological groups, polymers, silicas or silica supported substrates.

6124427, Sep 26, 2000

Mar 31, 1997

8/831289

David Allan Atwood - Fargo ND

North Dakota State University

C08F 600
C08J 300

528485

The invention is directed to making inorganic materials consisting of a metal and a group 16 element in the stoichiometric ratio of 2:3 from single source precursors having the same 2:3 metal to heteroatom stoichiometric ratio. In particular, the invention discloses a process for making aluminum oxide from single source precursors that have an aluminum to oxygen ratio of 2:3. The precursors are organoaluminum tetrametallic compounds containing organooxy bridging groups and organo terminal groups. As these compounds tend to be viscous liquids or oils, they can be applied to a substrate surface then pyrolyzed to eliminate the organic ligands and produce aluminum oxide in situ, without using gas phase deposition techniques.