David Engelke resumes & CV records
Resumes
David R Engelke, Age 72Denver, CO
David Engelke Phones & Addresses
Denver, CO
1500 Maywood Ave, Ann Arbor, MI 48103
402 Kellogg St #16, Ann Arbor, MI 48105
313 Westwood Ave, Ann Arbor, MI 48103
Social networks
David R Engelke
Linkedin
Mentions for David R Engelke
Publications & IP owners
Us Patents
Intracellular Expression And Delivery Of Sirnas In Mammalian Cells
US Patent:
2009004, Feb 12, 2009
Filed:
Aug 21, 2008
Appl. No.:
12/195724
Inventors:
David R. Engelke - Ann Arbor MI, US
Paul D. Good - Grass Lake MI, US
Cynthia P. Paul - Northville MI, US
Paul D. Good - Grass Lake MI, US
Cynthia P. Paul - Northville MI, US
International Classification:
C12Q 1/68
C12N 15/87
C12N 15/87
US Classification:
435 6, 435455
Abstract:
The present invention relates to compositions and methods for intracellular expression and delivery of siRNAs in mammalian cells. The siRNA is transcribed intracellularly as a double stranded RNA of about 18 to about 25 base pairs long from an expression cassette. Intracellular expression of siRNA is effective at reducing or eliminating expression of the targeted genes, and is applicable to reverse genetic analysis of genes and to genetic therapy, as for example to inhibiting expression of pathogenic genes and oncogenes.
Intracellular Expression And Delivery Of Sirnas In Mammalian Cells
US Patent:
2003014, Aug 7, 2003
Filed:
Nov 14, 2002
Appl. No.:
10/294957
Inventors:
David Engelke - Ann Arbor MI, US
Paul Good - Grass Lake MI, US
Cynthia Paul - Northville MI, US
Paul Good - Grass Lake MI, US
Cynthia Paul - Northville MI, US
International Classification:
C12N015/85
C12N005/06
C12N005/06
US Classification:
435/455000, 435/325000, 435/320100
Abstract:
The present invention relates to compositions and methods for intracellular expression and delivery of siRNAs in mammalian cells. The siRNA is transcribed intracellularly as a double stranded RNA of about 18 to about 25 base pairs long from an expression cassette. Intracellular expression of siRNA is effective at reducing or eliminating expression of the targeted genes, and is applicable to reverse genetic analysis of genes and to genetic therapy, as for example to inhibiting expression of pathogenic genes and oncogenes.
Inhibitors Of Dek Protein And Related Methods
US Patent:
2020018, Jun 11, 2020
Filed:
Feb 11, 2020
Appl. No.:
16/787647
Inventors:
- ANN ARBOR MI, US
Nirit Mor-Vaknin - Ann Arbor MI, US
Maureen Legendre - Ann Arbor MI, US
David Engelke - Ann Arbor MI, US
Kristine Benford - Ann Arbor MI, US
Dave Pai - Ann Arbor MI, US
Nirit Mor-Vaknin - Ann Arbor MI, US
Maureen Legendre - Ann Arbor MI, US
David Engelke - Ann Arbor MI, US
Kristine Benford - Ann Arbor MI, US
Dave Pai - Ann Arbor MI, US
International Classification:
C12N 15/115
A61K 45/06
A61K 31/7105
A61K 31/711
A61K 31/7115
A61K 31/713
C12Q 1/00
C12N 15/00
G01N 33/53
A61K 45/06
A61K 31/7105
A61K 31/711
A61K 31/7115
A61K 31/713
C12Q 1/00
C12N 15/00
G01N 33/53
Abstract:
The present invention provides methods of treatment using inhibitors of DEK protein and DEK activity. Such methods include, but are not limited to, methods of preventing, treating, and/or ameliorating inflammatory diseases, infections, autoimmune diseases, malignant diseases, and other diseases or conditions in which DEK has been implicated. Such inhibitors of DEK protein include, but are not limited to, pharmaceutical compositions including single stranded DNA or RNA aptamers capable of binding to DEK. In some embodiments, such aptamers are useful for diagnosing DEK related diseases or conditions. Related kits and compositions are further provided.
Inhibitors Of Dek Protein And Related Methods
US Patent:
2019007, Mar 7, 2019
Filed:
Nov 15, 2018
Appl. No.:
16/191774
Inventors:
- Ann Arbor MI, US
Nirit Mor-Vaknin - Ann Arbor MI, US
Maureen Legendre - Ann Arbor MI, US
David Engelke - Ann Arbor MI, US
Kristine Benford - Ann Arbor MI, US
Dave Pai - Ann Arbor MI, US
Nirit Mor-Vaknin - Ann Arbor MI, US
Maureen Legendre - Ann Arbor MI, US
David Engelke - Ann Arbor MI, US
Kristine Benford - Ann Arbor MI, US
Dave Pai - Ann Arbor MI, US
International Classification:
C12N 15/115
A61K 45/06
G01N 33/53
A61K 31/7105
A61K 31/711
A61K 31/7115
A61K 31/713
C12Q 1/00
C12N 15/00
A61K 45/06
G01N 33/53
A61K 31/7105
A61K 31/711
A61K 31/7115
A61K 31/713
C12Q 1/00
C12N 15/00
Abstract:
The present invention provides methods of treatment using inhibitors of DEK protein and DEK activity. Such methods include, but are not limited to, methods of preventing, treating, and/or ameliorating inflammatory diseases, infections, autoimmune diseases, malignant diseases, and other diseases or conditions in which DEK has been implicated. Such inhibitors of DEK protein include, but are not limited to, pharmaceutical compositions including single stranded DNA or RNA aptamers capable of binding to DEK. In some embodiments, such aptamers are useful for diagnosing DEK related diseases or conditions. Related kits and compositions are further provided.
Inhibitors Of Dek Protein And Related Methods
US Patent:
2018018, Jul 5, 2018
Filed:
Mar 11, 2016
Appl. No.:
15/557757
Inventors:
- Ann Arbor MI, US
Nirit MOR-VAKNIN - Ann Arbor MI, US
Maureen LEGENDRE - Ann Arbor MI, US
David ENGELKE - Ann Arbor MI, US
Kristine ANGEVINE - Ann Arbor MI, US
David PAI - Ann Arbor MI, US
Nirit MOR-VAKNIN - Ann Arbor MI, US
Maureen LEGENDRE - Ann Arbor MI, US
David ENGELKE - Ann Arbor MI, US
Kristine ANGEVINE - Ann Arbor MI, US
David PAI - Ann Arbor MI, US
International Classification:
C12N 15/115
A61K 31/713
A61K 45/06
G01N 33/53
A61K 31/713
A61K 45/06
G01N 33/53
Abstract:
The present invention provides methods of treatment using inhibitors of DEK protein and DEK activity. Such methods include, but are not limited to, methods of preventing, treating, and/or ameliorating inflammatory diseases, infections, autoimmune diseases, malignant diseases, and other diseases or conditions in which DEK has been implicated. Such inhibitors of DEK protein include, but are not limited to, pharmaceutical compositions including single stranded DNA or RNA aptamers capable of binding to DEK. In some embodiments, such aptamers are useful for diagnosing DEK related diseases or conditions. Related kits and compositions are further provided.
Isbn (Books And Publications)
Methods In Enzymology: Rna Interference
Author:
David R. Engelke
ISBN #:
0121827976
Rna Interference: Nuts &Amp; Bolts Of Rnai Technology
Author:
David R. Engelke
ISBN #:
1933255153
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