David A Fournier, Age 71Globe Village, MA

2012019, Aug 2, 2012

Feb 25, 2011

13/035472

David Fournier - Northborough MA, US
Todd Campbell - Holliston MA, US
Cheuk Kan - Boston MA, US
John Lawson - Petersham MA, US
Andrew Rivnak - Somerville MA, US
Michael Kagan - Sebec ME, US
David C. Duffy - Somerville MA, US

Quanterix Corporation - Cambridge MA

C40B 50/18
B05D 5/10
C40B 60/14
C40B 60/12
C40B 60/00

506 32, 506 39, 506 33, 506 40, 4272071, 156145

Described are systems, devices, and methods which related to various aspects of assays for detecting and/or determining a measure of the concentration of analyte molecules or particles in a sample fluid. In some cases, the systems employ an assay consumable comprising a plurality of assay sites. The systems, devices, and/or methods, in some cases, are automated. In some cases, the systems, devices, and/or methods relate to inserting a plurality of beads into assay sites, sealing assay sites, imaging assay sites, or the like.

2013016, Jun 27, 2013

Feb 15, 2013

13/768843

David Fournier - Northborough MA, US
David C. Duffy - Somerville MA, US

Quanterix Corporation - Lexington MA

G01N 33/50

506 9, 422 69, 436518, 435 79, 4352871, 506 39

Described herein are systems and methods for extending the dynamic range of assay methods and systems used for determining the concentration of analyte molecules or particles in a fluid sample. In some embodiments, a method comprises spatially segregating a plurality of analyte molecules in a fluid sample into a plurality of locations. At least a portion of the locations may be addressed to determine the percentage of said locations containing at least one analyte molecule. Based at least in part on the percentage, a measure of the concentration of analyte molecules in the fluid sample may be determined using an analog, intensity-based detection/analysis method/system and/or a digital detection/analysis method/system. In some cases, the assay may comprise the use of a plurality of capture objects.

5640473, Jun 17, 1997

Jul 2, 1996

8/677343

Joseph A. Wheeler - Vernon CT
David R. Fournier - Groton MA
Ronald J. Straayer - South Windsor CT

Gerber Systems Corporation - South Windsor CT

G02B 626

385 27

An optical beam generator system for use in an imaging system that forms an image in a substrate comprises a beam generator, a mode filter and a state selector. The optical beam has a first power level above an exposure level that exposes the image in the substrate and a second power level below the exposure level which does not expose the substrate. The beam generator generates a near single mode coherent optical beam in response to received command signals corresponding to an "on" state and generates a multimode incoherent optical beam in response to received command signals corresponding to an "off" state. The filter is optically coupled to the beam generator and attenuates an optical component of the received optical beam which is not single mode to a magnitude below the exposure level. The state selector generates the "on" and "off" command signals corresponding to the "on" and "off" states such that the filter outputs the coherent optical beam with minimal attenuation during the "on" state and with maximum attenuation during the "off" state.

2021031, Oct 7, 2021

Apr 5, 2021

17/222858

- Farmington CT, US
David Fournier - Northborough MA, US
Rishikesh Pandey - Unionville CT, US

G01J 3/44
A61B 5/00

A method and system for identifying a Raman spectrum component of an observed spectrum is provided. The observed spectrum is produced by interrogating a material such as a tissue sample with light at the one or more predetermined wavelengths, and the observed spectrum includes a background fluorescence component representative of fluorescent emissions resulting from the light interrogation and a Raman spectrum component representative of a Raman scattering resulting from the light interrogation. The method includes a) creating a reconstructed fluorescence spectrum representative of the background fluorescence component of the observed spectrum using one or more empirically determined fluorescent spectral profiles; and b) identifying the Raman spectrum of the observed spectrum using the reconstructed fluorescence spectrum.

2021031, Oct 7, 2021

Mar 23, 2021

17/210258

- Billerica MA, US
David Fournier - Northborough MA, US
David C. Duffy - Arlington MA, US

Quanterix Corporation - Billerica MA

G01N 33/573
G01N 21/64
G01N 33/543

Described herein are systems and methods for extending the dynamic range of assay methods and systems used for determining the concentration of analyte molecules or particles in a fluid sample. In some embodiments, a method comprises spatially segregating a plurality of analyte molecules in a fluid sample into a plurality of locations. At least a portion of the locations may be addressed to determine the percentage of said locations containing at least one analyte molecule. Based at least in part on the percentage, a measure of the concentration of analyte molecules in the fluid sample may be determined using an analog, intensity-based detection/analysis method/system and/or a digital detection/analysis method/system. In some cases, the assay may comprise the use of a plurality of capture objects.

2018022, Aug 9, 2018

Nov 10, 2017

15/808969

- Lexington MA, US
David Fournier - Northborough MA, US
David C. Duffy - Arlington MA, US

Quanterix Corporation - Lexington MA

G01N 33/573
G01N 33/543
G01N 21/64

Described herein are systems and methods for extending the dynamic range of assay methods and systems used for determining the concentration of analyte molecules or particles in a fluid sample. In some embodiments, a method comprises spatially segregating a plurality of analyte molecules in a fluid sample into a plurality of locations. At least a portion of the locations may be addressed to determine the percentage of said locations containing at least one analyte molecule. Based at least in part on the percentage, a measure of the concentration of analyte molecules in the fluid sample may be determined using an analog, intensity-based detection/analysis method/system and/or a digital detection/analysis method/system. In some cases, the assay may comprise the use of a plurality of capture objects.

2015035, Dec 10, 2015

Aug 17, 2015

14/827815

- Lexington MA, US
David Fournier - Northborough MA, US
David C. Duffy - Arlington MA, US

Quanterix Corporation - Lexington MA

G01N 33/573
G01N 21/64

Described herein are systems and methods for extending the dynamic range of assay methods and systems used for determining the concentration of analyte molecules or particles in a fluid sample. In some embodiments, a method comprises spatially segregating a plurality of analyte molecules in a fluid sample into a plurality of locations. At least a portion of the locations may be addressed to determine the percentage of said locations containing at least one analyte molecule. Based at least in part on the percentage, a measure of the concentration of analyte molecules in the fluid sample may be determined using an analog, intensity-based detection/analysis method/system and/or a digital detection/analysis method/system. In some cases, the assay may comprise the use of a plurality of capture objects.