Inventors:
Jill E. Wood - North Haven CT
Jeremy L. Baryza - Mountain View CA
Catherine R. Brennan - Hamden CT
Soongyu Choi - Trumbull CT
James H. Cook - East Hampton CT
Brian R. Dixon - Woodbridge CT
Paul P. Ehrlich - Duesseldorf-Wittlaer, DE
David E. Gunn - Hamden CT
Ian McAlexander - Pocatello ID
Peiying Liu - Madison CT
Derek B. Lowe - Hamden CT
William J. Scott - Guilford CT
Yamin Wang - Sandy Hook CT
Assignee:
Bayer Pharmaceuticals Corporation - West Haven CT
International Classification:
A61K 3140
US Classification:
514 63, 5142278, 5142372, 51425401, 514274, 514314, 514343, 514365, 514411, 514414, 514422, 514424, 544 582, 544 587, 544 60, 544141, 544316, 544372, 546167, 5462784, 548204, 548205, 548406, 548450, 548468, 548517, 548518, 548525, 548526, 548527, 548551
Abstract:
17-beta-hydroxysteroid dehydrogenase-II inhibitors having the structural formula wherein the phenyl group labeled A and the group âC(R )(R )Y are oriented cis to each other; W represents O or S; R represents âH or optionally substituted â(C -C )alkyl; n represents 0 or an integer of 1-3; and R represents any of a variety of substituents on ring A. R generally represents âH but may be a bond terminating at the ortho position of ring A. Y represents fluorine, âOR , or âSR , and R represents âH, optionally substituted â(C -C )alkyl, optionally substituted -phenyl, optionally substituted â(C -C )alkyl-phenyl, or optionally substituted â(C -C )acyl. R represents any of a variety of groups as defined in the specification and claims, including heteroaryl, arylalkyl, heteroarylalkyl, arylalkenyl, heteroarylalkenyl, alkynyl, arylalkynyl, heteroarylalkynyl, aryl, and indolyl. Pharmaceutically acceptable salts and N-oxides of these materials are also included.