David E Laufer, Age 43Saylorsburg, PA

6090981, Jul 18, 2000

May 19, 1998

9/081143

Heinrich Englert - Hofheim, DE
Dieter Mania - Konigstein, DE
Jens Hartung - Rodgau, DE
Heinz Gogelein - Frankfurt am Main, DE
Joachim Kaiser - Frankfurt am Main, DE
Wolfgang Linz - Mainz, DE
David W. Laufer - Phillipsburg NJ

Hoechst Aktiengesellschaft - Frankfurt am Main

C07C31116

564 86

Benzenesulfonylureas and -thioureas of the formula I ##STR1## where R(1) is H or (fluoro)methyl, R(2) is H, Hal or (fluoro)(mercapto)alk(ozy)yl, E is O or S; Y is --[CR(3). sub. 2 ]. sub. n --, where R(3)=H or alkyl and n=1-4, X is H, Hal or alkyl and Z in Hal, NO. sub. 2 or alk(yl)oxy, are described. The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used as antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.