Career records & work history
Medicine Doctors
David Navarre Reifsnyder
Specialties:
Internal Medicine
Infectious Disease
Infectious Disease
Education:
Columbia University (1963) Internal Medicine
David T Reifsnyder Deceased19 Pueblo Dr, San Rafael, CA 94903
David Reifsnyder Phones & Addresses
19 Pueblo Dr, San Rafael, CA 94903
Azusa, CA
West Covina, CA
Novato, CA
Azusa, CA
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David T Reifsnyder
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Resumes
David Reifsnyder
Publications & IP owners
Us Patents
Method Of Purifying Tfpi And Tfpi Analogs
US Patent:
7851433, Dec 14, 2010
Filed:
Jan 8, 2004
Appl. No.:
10/753078
Inventors:
David H. Reifsnyder - El Cerrito CA, US
Duane Inlow - Alamo CA, US
Glenn Dorin - San Rafael CA, US
Patricio T. Riquelme - Walnut Creek CA, US
Cynthia A. Cowgill - Berkeley CA, US
Douglas G. Bolesch - Berkeley CA, US
Mark E. Gustafson - St. Charles MO, US
Duane Inlow - Alamo CA, US
Glenn Dorin - San Rafael CA, US
Patricio T. Riquelme - Walnut Creek CA, US
Cynthia A. Cowgill - Berkeley CA, US
Douglas G. Bolesch - Berkeley CA, US
Mark E. Gustafson - St. Charles MO, US
Assignee:
Novartis Vaccines and Diagnostics, Inc. - Emeryville CA
Pharmacia & Upjohn Company - Kalamazoo MI
Pharmacia & Upjohn Company - Kalamazoo MI
International Classification:
C07K 14/00
US Classification:
514 2, 530350
Abstract:
Highly purified preparations of TFPI or TFPI analogs can be prepared using a method that generally involves the following steps: (1) expression of TFPI or TFPI analog in , (2) isolation of refractile bodies, (3) dissolution of the refractile bodies and refolding of the expressed TFPI or TFPI analog, (4) SP-Sepharose fast flow (FF) chromatography, (5) a first concentration and diafiltration step, (6) Q-Sepharose high (HP) performance chromatography, (7) butyl hydrophobic interaction chromatography (HIC), (8) SP-Sepharose HP chromatography, and (9) a second concentration/diafiltration step. Less than about 12% of the TFPI or TFPI analog molecules in such preparations are modified TFPI or TFPI analog species (i. e. , oxidized, carbamylated, acetylated, deamidated, aggregated, or misfolded species).
Purification Of Molecules
US Patent:
6265542, Jul 24, 2001
Filed:
Oct 8, 1998
Appl. No.:
9/168548
Inventors:
Robert Lee Fahrner - San Francisco CA
David Reifsnyder - El Cerrito CA
David Reifsnyder - El Cerrito CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C07K 114
C07K 116
C07K 116
US Classification:
530344
Abstract:
A process for purifying molecules from contaminants is provided. In this process a mixture containing the molecule (peptide, polypeptide, or biologically active non-peptidyl compound) and its contaminants is loaded onto a reversed-phase liquid chromatography column and the molecule is eluted from the column with a buffer containing hexylene glycol.
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