David G Winkler, Age 58127 George St, Arlington, MA 02476

6395511, May 28, 2002

Nov 24, 1999

09/449218

Mary E. Brunkow - Seattle WA
David J. Galas - Mercer Island WA
Brian Kovacevich - Renton WA
John T. Mulligan - Seattle WA
Bryan W. Paeper - Seattle WA
Jeffrey Van Ness - Seattle WA
David G. Winkler - Seattle WA

Darwin Discovery, Ltd. - Bothell WA

C12P 2106

435 691, 4353201, 4352523, 43525411, 435325, 435419, 536 231, 536 232, 536 2431, 536 245

A novel human protein has been isolated which is encoded by a nucleic acid molecule comprising the polynucleotide sequence provided in SEQ ID NO:1 or a polynucleotide sequence that is completely complementary thereto. This novel protein binds to at least two members of the family of TGF-beta proteins, which are the human bone morphogenic protein-5 and human bone morphogenic protein-6.

6489445, Dec 3, 2002

Sep 21, 2000

09/668529

Mary E. Brunkow - Seattle WA
David J. Galas - Mercer Island WA
Brian Kovacevich - Renton WA
John T. Mulligan - Seattle WA
Bryan W. Paeper - Seattle WA
Jeffrey Van Ness - Seattle WA
David G. Winkler - Seattle WA

Celltech RD, Inc. - Bothell WA

C07K 100

530350, 530300

Compositions and methods for increasing bone density using antibodies directed to a novel class or family human of TGF- binding proteins are disclosed. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis. The disclosed compositions include polypeptides, and their encoding polynucleotides, which specifically bind to at least one human bone morphogenic protein (BMP) selected from BMP-5 and BMP-6.

6495736, Dec 17, 2002

Sep 21, 2000

09/668037

Mary E. Brunkow - Seattle WA
David J. Galas - Mercer Island WA
Brian Kovacevich - Renton WA
John T. Mulligan - Seattle WA
Bryan W. Paeper - Seattle WA
Jeffrey Van Ness - Seattle WA
David G. Winkler - Seattle WA

Darwin Discovery, Ltd. - Bothell WA

A01K 67027

800 18, 800 13

A novel class or family of TGF- binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.

6681391, Jan 20, 2004

Jun 21, 2000

09/598521

Phillip J. Marino - Dublin OH
David V. Winkler - Seattle WA
Crista Johnson - Seattle WA
William M. Nelson - Seattle WA

Microsoft Corporation - Redmond WA

G06F 9445

717175, 717174, 717176, 711217, 711133, 711134, 711154, 711158, 711165, 709102

A method and system for installing software on a computer generates an installation order that ensures that a component required for the functioning of another component is already installed. Furthermore, it makes possible generating good installation orders to allow related components, e. g. , in a software suite, to be installed close together, thus reducing disk swapping. The method and system take into account the existing configuration on a computer and allow removal of components along with dynamic reconfiguration of a computing system in response to a users choice of an application program to launch. In accordance with the invention, preferably a developer includes information about the components relationship with other components, e. g. , a specific requirement for a preinstalled component or a requirement that a particular component not be present, thus requiring its removal. To remove the possibility of a single identifier referring to more than one component, the preferred embodiments of the invention use globally unique identifiers to label individual components.

6803453, Oct 12, 2004

Sep 21, 2000

09/668021

Mary E. Brunkow - Seattle WA
David J. Galas - Mercer Island WA
Brian Kovacevich - Renton WA
John T. Mulligan - Seattle WA
Bryan W. Paeper - Seattle WA
Jeffrey Van Ness - Seattle WA
David G. Winkler - Seattle WA

Darwin Discovery Ltd. - Bothell WA

C07K 1600

53038823, 435331, 4241841, 5303871, 5303881, 5303882, 5303892

Compositions and methods for increasing bone density using antibodies directed to a novel class or family of TGF- binding proteins are provided. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis.

6986106, Jan 10, 2006

May 13, 2002

10/145425

Ravipal Soin - Bellevue WA, US
Adrian J. Garside - Sammamish WA, US
David V. Winkler - Seattle WA, US
Luis M. Huapaya - Redmond WA, US
Marieke Iwema - Seattle WA, US

Microsoft Corporation - Redmond WA

G06F 17/00

715532, 715531

A correction tool that displays a correction widget when a user acts to correct text is provided. More particularly, if the user places an insertion point in or to the immediate left of the text, or selects the text, the tool displays the correction widget immediately to the left of the selected text. The user can then quickly access a correction interface for correcting the text simply by moving the pointer the short distance from the insertion point to the correction widget. When the user activates the correction widget, the tool displays the correction interface immediately proximal to the correction widget. Thus, the user need only move the pointer a small distance further to then correct the text using the correction interface.

7192583, Mar 20, 2007

Mar 6, 2003

10/384893

Mary E Brunkow - Seattle WA, US
David J Galas - Claremont CA, US
Brian Kovacevich - Renton WA, US
John T Mulligan - Seattle WA, US
Bryan W Paeper - Seattle WA, US
Jeffrey Van Ness - Claremont CA, US
David G Winkler - Seattle WA, US

Darwin Discovery Ltd. - Bothell WA

A61K 39/395

4241391, 4241331, 4241351, 4241411, 4241451, 5303879, 5303881, 53038824

Antibodies to a novel family of TGF-β binding proteins are disclosed, for use in methods of altering bone density and bone mineralization, which methods are applicable to the treatment of diseases including osteopenia and osteoporosis.

7226902, Jun 5, 2007

Mar 12, 2004

10/799162

David G. Winkler - Seattle WA, US
John Latham - Seattle WA, US
John Skonier - Shoreline WA, US
Diana Shpektor - Bothell WA, US
Trenton Hayes - Seattle WA, US
James Geoghegan - Seattle WA, US

Celltech R&D, Inc. - Bothell WA

C07K 14/00
A61K 38/00

514 2, 530350

Compositions and methods are provided that relate to the unexpected specific association of (i) the TGF-beta binding protein sclerostin with the BMP antagonist protein chordin to form a complex, and of (ii) the TGF-beta binding protein sclerostin with the BMP antagonist protein noggin to form a complex, either of which complex is incapable of binding to a TGF-beta superfamily member such as a BMP. The invention provides isolated complexes for use in screening assays to identify agents that modulate bone mineralization, and offers other related advantages.