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Dennis J Thiele, Age 68Salem, MA

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Known as:
Dennis James Thiele Dennis G Thiele Denny Thiele
Related to:
Migdalia Figueroa 50

Dennis Thiele Phones & Addresses

Salem, MA

2705 Creek Ridge Ln, Chapel Hill, NC 27514 (919) 933-5627

Ann Arbor, MI

Penfield, NY

Rockville, MD

Bethesda, MD

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Dennis Thiele

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Us Patents

Compositions And Methods Relating To Heat Shock Transcription Factor Activating Compounds And Targets Thereof

US Patent:
2011011, May 12, 2011
Filed:
Nov 12, 2010
Appl. No.:
12/945522
Inventors:
Dennis J. Thiele - Chapel Hill NC, US
Daniel W. Neef - Durham NC, US
Jose S. Mendoza - Chapel Hill NC, US
Assignee:
DUKE UNIVERSITY - Durham NC
International Classification:
A61K 31/55
C07D 231/38
A61K 31/415
C07D 277/46
A61K 31/426
C07D 239/80
A61K 31/517
C07D 271/07
A61K 31/4245
C07D 409/04
A61K 31/4155
C07D 277/60
A61K 31/428
C07D 405/14
C07D 413/12
C07C 211/27
A61K 31/137
C07D 401/12
C07D 295/135
A61K 31/495
A61P 25/16
A61P 25/28
A61P 9/00
A61P 27/02
A61P 17/02
US Classification:
51421704, 5483725, 514407, 548195, 514371, 544286, 5142663, 548133, 514364, 5483657, 548150, 514366, 544284, 51426621, 564367, 514649, 540597, 544392, 51425503
Abstract:
The present invention relates to HSF activating compounds, methods for their discovery, and their research and therapeutic uses, as well as pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, mixtures (including both R and S enantiomeric forms and racemic mixtures thereof), and pharmaceutical Formulations thereof. In particular, the present invention provides compounds capable of facilitating HSF1 homotrimerization, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with irregular HSF1 activity.

Combination Cancer Treatment

US Patent:
2011028, Nov 24, 2011
Filed:
Apr 22, 2011
Appl. No.:
13/092341
Inventors:
Mark Wesley Dewhirst - Durham NC, US
Dennis J. Thiele - Chapel Hill NC, US
Chelsea D. Landon - Durham NC, US
International Classification:
A61K 33/24
A61K 31/282
A61P 35/00
A61K 31/27
US Classification:
424649, 514479, 514492
Abstract:
Described herein are methods of inhibiting the proliferation of cancer cells and methods of treating cancer, by administering a combination of a copper chelator and a platinum-based chemotherapeutic.

Compositions And Methods Relating To Heat Shock Transcription Factor Activating Compounds And Targets Thereof

US Patent:
2013026, Oct 10, 2013
Filed:
Nov 8, 2011
Appl. No.:
13/884666
Inventors:
Dennis J. Thiele - Chapel Hill NC, US
Daniel W. Neef - Durham NC, US
Jose S. Mendoza - Chapel Hill NC, US
Assignee:
CHAPERONE THERAPEUTICS, INC. - Durham NC
DUKE UNIVERSITY - Durham NC
International Classification:
C07C 211/01
C07D 409/04
C07D 413/12
C07D 277/60
C07D 405/14
C07D 231/38
C07D 277/38
US Classification:
51426621, 514407, 5483725, 5483657, 514370, 548199, 514371, 548195, 514366, 548150, 544284, 514364, 548131, 514655, 564372
Abstract:
The present invention relates to HSF activating compounds, methods for their discovery, and their research and therapeutic uses, as well as pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, mixtures (including both R and S enantiomeric forms and racemic mixtures thereof), and pharmaceutical Formulations thereof. In particular, the present invention provides compounds capable of facilitating HSF1 homotrimerization, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with irregular HSF1 activity.

Yeast Mammalian Regulators Of Cell Proliferation

US Patent:
6383753, May 7, 2002
Filed:
Mar 31, 2000
Appl. No.:
09/540824
Inventors:
Dennis J. Thiele - Ann Arbor MI
Phillip C. C. Liu - Ann Arbor MI
Assignee:
Regents of the University of Michigan - Ann Arbor MI
International Classification:
C12Q 168
US Classification:
435 6, 435 691, 536 221
Abstract:
Novel, highly conserved cell cycle regulatory genes (Emg1 and ENIP1) are described along with methods employing Emg1 and ENIP1 to detect compounds that are agonistic or antagonistic to cell cycle progression.

Prochelators As Broad-Spectrum Antimicrobial Agents And Methods Of Use

US Patent:
2017022, Aug 10, 2017
Filed:
Dec 20, 2016
Appl. No.:
15/385550
Inventors:
- Durham NC, US
Dennis J. Thiele - Chapel Hill NC, US
Marian Helsel - Durham NC, US
Richard Festa - North Chesterfield VA, US
International Classification:
A61K 31/69
Abstract:
The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The present disclosure further provides pharmaceutical compositions and a kit comprising the prochelator therein.

Prochelators As Broad-Spectrum Antimicrobial Agents And Methods Of Use

US Patent:
2016022, Aug 4, 2016
Filed:
Apr 8, 2016
Appl. No.:
15/094349
Inventors:
- Durham NC, US
Dennis J. Thiele - Chapel Hill NC, US
Marian Helsel - Durham NC, US
Richard Festa - North Chesterfield VA, US
International Classification:
A61K 31/69
Abstract:
The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The present disclosure further provides pharmaceutical compositions and a kit comprising the prochelator therein.

Methods Of Treating And Preventing Cancer By Disrupting The Binding Of Copper In The Map Kinase Pathway

US Patent:
2015001, Jan 15, 2015
Filed:
Jan 11, 2013
Appl. No.:
14/371871
Inventors:
- Durham NC, US
Donita C. Brady - Durham NC, US
Michelle L. L. Turski - San Francisco CA, US
Dennis J. Thiele - Chapel Hill NC, US
International Classification:
A61K 33/24
A61K 45/06
US Classification:
424646
Abstract:
The present disclosure provides methods of treating and/or preventing cancer in a subject comprising administering to the subject a copper-reduced diet by itself or as a supplement along with a regular diet to create a copper-reduced melieu, maintain a reduced-copper melieu, or both, thereby treating and/or preventing the development of the cancer. Methods also comprise further adding a copper chelator, MEK inhibitor, or combinations thereof.

Prochelators As Broad-Spectrum Antimicrobial Agents And Methods Of Use

US Patent:
2014027, Sep 18, 2014
Filed:
Mar 14, 2014
Appl. No.:
14/213207
Inventors:
- Durham NC, US
Dennis J. Thiele - Chapel Hill NC, US
Marian Helsel - Durham NC, US
Richard Festa - Durham NC, US
Assignee:
Duke University - Durham NC
International Classification:
A61K 31/69
US Classification:
514 64
Abstract:
The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The present disclosure further provides pharmaceutical compositions and a kit comprising the prochelator therein.

Public records

Vehicle Records

Dennis Thiele

Address:
2705 Crk Rdg Ln, Chapel Hill, NC 27514
Phone:
(919) 933-5627
VIN:
1W7B1221571013978
Make:
Volkswagen
Model:
Rabbit 4dr Hatchback L
Year:
2007

Possible Relatives

Aaron Thiele  Douglas Thiele  Duane M Thiele  Edward A Thiele  Erin N Thiele  Gary E Thiele  Henry N Thiele  Dennis W Johnson  Dennis J Stanczak  Dennis R Standifer 

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