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Donald G Comb, Age 979 Proctor St, Manchester, MA 01944

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Known as:
Don Comb
Related to:
Lynne G Comb 63

Donald Comb Phones & Addresses

9 Proctor St, Manchester by the Sea, MA 01944 (978) 526-7751 (978) 922-4941

Manchester, MA

109 Water St, Beverly, MA 01915 (978) 921-0314

Saugus, MA

Prides Crossing, MA

Gloucester, MA

Boston, MA

9 Proctor St, Manchester, MA 01944 (978) 979-4431

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Work

Position: Retired

Education

Degree: High school graduate or higher

Emails

d***[email protected]

Mentions for Donald G Comb

Publications & IP owners

Us Patents

Method For Generating Split, Non-Transferable Genes That Are Able To Express An Active Protein Product

US Patent:
6858775, Feb 22, 2005
Filed:
May 23, 2000
Appl. No.:
09/936588
Inventors:
Thomas C. Evans - Somerville MA, US
Sriharsa Pradhan - Beverly MA, US
Donald G. Comb - Manchester MA, US
Henry Paulus - Boston MA, US
Luo Sun - Hamilton MA, US
Lixin Chen - Beverly MA, US
Inca Ghosh - Somerville MA, US
Assignee:
New England Biolabs, Inc. - Beverly MA
International Classification:
A01H001/00
US Classification:
800278
Abstract:
A new type of transgene system is disclosed which allows efficient protein expression in a target host such as a plant, but avoids the undesirable result of the migration of the transgene into related host system and/or to the environment via the pollen. The methods described herein may also be applied to the expression of virtually any protein of interest (e. g. a toxic protein) in eukaryotic (yeast, insect, mammalian cells, etc. ) and prokaryotic (, etc. ) organisms.

Method For Generating Split, Non-Transferable Genes That Are Able To Express An Active Protein Product

US Patent:
2004009, May 20, 2004
Filed:
Jun 3, 2003
Appl. No.:
10/377134
Inventors:
Thomas Evans - Somerville MA, US
Sriharsa Pradhan - Wenham MA, US
Donald Comb - Manchester MA, US
Henry Paulus - Boston MA, US
Luo Sun - Hamilton MA, US
Lixin Chen - Beverly MA, US
Inca Ghosh - Somerville MA, US
International Classification:
C12P021/06
C12N015/63
C12N015/85
C12N015/87
C12N015/74
C12N015/86
US Classification:
435/069100, 435/455000, 435/456000, 435/468000, 435/471000
Abstract:
A new type of transgene system is disclosed which allows efficient protein expression in a target host such as a plant, but avoids the undesirable result of the migration of the transgene into related host systems and/or to the environment via the pollen. The methods described herein may also be applied to the expression of virtually any protein of interest (e.g. a toxic protein) in eukaryotic (yeast, insect, mammalian cells, etc.) and prokaryotic (, etc.) organisms.

Conversion Of Chitin Into N-Acetylglucosamine, Glucosamine And Bioethanol

US Patent:
2012014, Jun 7, 2012
Filed:
Apr 16, 2010
Appl. No.:
13/264273
Inventors:
Saul Roseman - Pikesville MD, US
Xibing Li - Phoenix MD, US
Donald Comb - Manchester MA, US
International Classification:
C12P 7/14
C12P 19/26
C12N 15/74
C12N 1/21
US Classification:
435 84, 4352523, 435471, 435162
Abstract:
Compositions and methods are provided for converting chitin into N-acetylglucosamine, glucosamine and ethanol. The chitin may be used directly from the environment, for example, as occurs in invertebrate cuticles, fungal cells and/or algae. Mutant bacteria were created by knocking out or inactivating one or more genes preferably resulting in the chitin catabolic sensor maintaining an activated state. Methods are further provided for converting the N-acetylglucosamine into ethanol by means of a genetically engineered yeast strain which can be optionally co-cultivated with the Vibrionaceae to produce significant yields of ethanol.

Modified Proteins Comprising Controllable Intervening Protein Sequences Or Their Elements Methods Of Producing Same And Methods For Purification Of A Target Protein Comprised By A Modified Protein

US Patent:
5834247, Nov 10, 1998
Filed:
Mar 5, 1997
Appl. No.:
8/811492
Inventors:
Donald G. Comb - Manchester MA
Francine B. Perler - Brookline MA
William E. Jack - Wenham MA
Robert A. Hodges - Norcross GA
Christopher J. Noren - Boxford MA
Shaorong S. C. Chong - Beverly MA
Eric Adam - Beverly MA
Maurice Southworth - Beverly MA
Assignee:
New England Biolabs, Inc. - Beverly MA
International Classification:
C12N 1562
C07K 1900
C12P 2100
C12P 2104
US Classification:
435 697
Abstract:
The present invention is directed to modified proteins and methods of their production. The modified proteins comprise a controllable intervening protein sequence (CIVPS) inserted into or adjacent a target protein, the CIVPS being capable of excision from or cleavage of the modified protein under predetermined conditions in cis or in trans, i. e. , increase in temperature, exposure to light, unblocking of amino acid residues by dephosphorylation, treatment with chemical reagents or deglycosylation. If desired, the modified protein can be subjected to these conditions. The CIVPS may also be inserted into a region that substantially inactivates target protein activity. The CIVPS may be used in a number of applications including purification of the target protein in a one-step protocol.

Recombinant Thermostable Dna Polymerase From Archaebacteria

US Patent:
5834285, Nov 10, 1998
Filed:
Apr 4, 1994
Appl. No.:
8/222715
Inventors:
Donald G. Comb - Beverly MA
Francine Perler - Brookline MA
Rebecca Kucera - Beverly MA
William E. Jack - Wenham MA
Assignee:
New England Biolabs, Inc. - Beverly MA
International Classification:
C12N 910
C12N 1554
C12N 1570
US Classification:
435194
Abstract:
Recombinant DNA polymerases from archaebacteria as well as isolated DNA coding for such polymerases are provided. The isolated DNA is obtained by use or DNA or antibody probes prepared from the DNA encoding T. litoralis DNA polymerase and the T. litoralis DNA polymerase respectively. Also provided are methods for producing recombinant archaebacteria thermostable DNA polymerase and methods for enhancing the expression of such polymerases by identifying, locating and removing introns from within the DNA coding for such DNA polymerases.

Modification Of Protein By Use Of A Controllable Interveining Protein Sequence

US Patent:
5496714, Mar 5, 1996
Filed:
Dec 9, 1992
Appl. No.:
8/004139
Inventors:
Donald G. Comb - Beverly MA
Francine B. Perler - Brookline MA
William E. Jack - Rowley MA
Robert A. Hodges - Manassas VA
Assignee:
New England Biolabs, Inc. - Beverly MA
International Classification:
C12P 2100
C12N 922
US Classification:
435 697
Abstract:
The present invention is directed to modified proteins and methods of their production. The modified proteins comprise a controllable intervening protein sequence (CIVPS) inserted into a target protein, the CIVPS being capable of excision from the modified protein under predetermined conditions, i. e. , increase in temperature, exposure to light, unblocking of amino acid residues by dephosphorylation or deglycosylation. If desired, the modified protein can be subjected to these conditions. The CIVPS may also be inserted into a region that substantially inactivates target protein activity.

Purified Thermostable Dna Polymerase Obtainable From Thermococcus Litoralis

US Patent:
5322785, Jun 21, 1994
Filed:
Apr 17, 1991
Appl. No.:
7/686340
Inventors:
Donald G. Comb - Beverly MA
Francine Perler - Brookline MA
Rebecca Kucera - Beverly MA
William E. Jack - Rowley MA
Assignee:
New England Biolabs, Inc. - Beverly MA
International Classification:
C12N 1554
C12N 1567
C12N 1570
C12N 1574
US Classification:
435194
Abstract:
There is provided an extremely thermostable enzyme obtainable from Thermococcus litoralis. The thermostable enzyme has a molecular weight of about 90,000-95,000 daltons, a half-life of about 60 minutes at 100. degree. C. in the absence of stabilizer, and a half-life of about 95 minutes at 100. degree. C. in the presence of stabilizer, such as octoxynol (TRITON X-100) or bovine serum albumin. The thermostable enzyme possesses a 3'-5' proofreading exonuclease activity. The thermostable enzyme may be native or recombinant and may be used for second-strand cDNA synthesis in cDNA cloning, DNA sequencing, and DNA amplification.

Recombinant Thermostable Dna Polymerase From Archaebacteria

US Patent:
5500363, Mar 19, 1996
Filed:
Sep 7, 1993
Appl. No.:
8/117491
Inventors:
Donald G. Comb - Beverly MA
Francine Perler - Brookline MA
Rebecca Kucera - Beverly MA
William E. Jack - Wenham MA
Assignee:
New England Biolabs, Inc. - Beverly MA
International Classification:
C12N 910
C12N 1511
C12N 1554
US Classification:
435194
Abstract:
Recombinant DNA polymerases from archaebacteria as well as isolated DNA coding for such polymerases are provided. The isolated DNA is obtained by use of DNA or antibody probes prepared from the DNA encoding T. litoralis DNA polymerase and the T. litoralis DNA polymerase respectively. Also provided are methods for producing recombinant archaebacteria thermostable DNA polymerase and methods for enhancing the expression of such polymerases by identifying, locating and removing introns from within the DNA coding for such DNA polymerases.

Possible Relatives

Donald J Johnson  Donald C Stanchfield  Donald C Stancil  Donald M Stanczak  Donald W Stanfill  Donald S Jones  Donald J Stankus  Donald L Stano  Donald G Stapp  Donald N Stearns 

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