Edward W Kennelly, Age 92167 Grand Ave, Leonia, NJ 07605

2011011, May 12, 2011

Jul 31, 2007

12/309804

Jeanine D'Armiento - New York NY, US
Kurt Reynertson - New York NY, US
Edward Kennelly - Bronx NY, US
Alison Wallace - New York NY, US

A61K 31/235
A61K 31/7048
A61P 29/00
A61P 35/00
A61P 9/00
A61P 11/00
A61P 19/02
A61K 33/36
A61K 31/704
A61K 33/24
A61K 31/282
A61K 31/4164
A61K 31/675
A61K 38/21
A61K 38/20
A61K 39/395
C07C 69/84
C12N 5/071
C12N 5/09

424 852, 514533, 514 27, 424629, 514 34, 424649, 514492, 514400, 514 83, 424 854, 4241331, 560 70, 435375

Methods for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside or an anthocyanin are provided. More particularly, a method for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside having the structure of formula (IV): Formula (IV) wherein R is selected from H or CHor an anthocyanin selected from cyanidin 3-glucoside, delphinidin 3-glucoside, or combinations thereof, or an enantiomer, optical isomer, diastereomer, N-oxide, crystalline form, hydrate, or pharmaceutically acceptable salt thereof is provided. Also provided are compounds according to Formulas I-IV, pharmaceutical compositions, unit dosage forms, and food or feed supplements containing such compounds. Methods for treating a condition in a mammal and for treating or ameliorating a condition, such as for example, chronic obstructive pulmonary disease (COPD) by administering an effective amount of a composition containing such compounds are also provided. Further provided is an extract obtained from the fruit of containing at least one compound of the present invention in substantially pure form.

2016030, Oct 27, 2016

Apr 25, 2016

15/137692

- New York NY, US
Edward N. Kennelly - Bronx NY, US
Peter Lipke - Brooklyn NY, US

A01N 35/06
A01N 43/653

Xanthochymol and garcinol, isoprenylated benzophenones purified from fruits, showed multiple activities against fungal biofilms. Both compounds effectively prevented emergence of fungal germ tubes and were also cytostatic, with MICs of 1 to 3 ΞM. The compounds therefore inhibited development of hyphae and subsequent biofilm maturation. Xanthochymol treatment of developing and mature biofilms induced cell death. In early biofilm development, killing had the characteristics of apoptosis. These activities resulted in failure of biofilm maturation and hyphal death in mature biofilms. In mature biofilms, xanthochymol and garcinol caused the death of biofilm hyphae, with 50% effective concentrations (ECs) of 30 to 50 μM. Additionally, xanthochymol-mediated killing was complementary with fluconazole against mature biofilms, reducing the fluconazole ECfrom greater than 1,024 μg per ml to 13 μg per ml.

2015001, Jan 8, 2015

Sep 22, 2014

14/492725

Jeanine D'Armiento - New York NY, US
Kurt Reynertson - New York NY, US
Edward Kennelly - Bronx NY, US
Alison Wallace - Vancouver, CA

The Trustees of Columbia University in the City of New York - New York NY

C07C 69/84

514533, 560 70

Methods for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside or an anthocyanin are provided. More particularly, a method for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside having the structure of formula (IV): Formula (IV) wherein R is selected from H or CHor an anthocyanin selected from cyanidin 3-glucoside, delphinidin 3-glucoside, or combinations thereof, or an enantiomer, optical isomer, diastereomer, N-oxide, crystalline form, hydrate, or pharmaceutically acceptable salt thereof is provided. Also provided are compounds according to Formulas I-IV, pharmaceutical compositions, unit dosage forms, and food or feed supplements containing such compounds. Methods for treating a condition in a mammal and for treating or ameliorating a condition, such as for example, chronic obstructive pulmonary disease (COPD) by administering an effective amount of a composition containing such compounds are also provided. Further provided is an extract obtained from the fruit of containing at least one compound of the present invention in substantially pure form.