Francis Anthony Ennis, Age 597 Hapgood Way, Shrewsbury, MA 01545

Francis Ennis Phones & Addresses

Shrewsbury, MA

Fort Lauderdale, FL

Rockport, MA

Charlestown, MA

8 Dialstone Ln, Riverside, CT 06878 (203) 246-8182

Needham, MA

Milford, CT

Durham, NC

85 Main St #R, Rockport, MA 01966

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Francis Anthony Ennis

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Work

Company: Umass medical school 1981 Position: Professor of medicine and molecular genetics and microbiology

Education

Degree: Doctor of Medicine, Doctorates, Bachelors, Bachelor of Arts School / High School: Tufts University School of Medicine 1960 to 1970 Specialities: Medicine

Industries

Research

Mentions for Francis Anthony Ennis

Career records & work history

Medicine Doctors

Francis Ennis Photo 1

Dr. Francis A Ennis, Worcester MA - MD (Doctor of Medicine)

Specialties:
Internal Medicine
Address:
Worcester Office
55 Lake Ave N, Worcester, MA 01655
(508) 334-1000 (Phone) (508) 856-6902 (Fax)
Certifications:
Internal Medicine, 1971
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
Worcester Office
55 Lake Ave N, Worcester, MA 01655
UMass Memorial Medical Center - University Campus
55 Lake Avenue North, Worcester, MA 01655
Education:
Medical School
Tufts University
Graduated: 1964
Medical School
SUNY Syracuse Hosp
Graduated: 1964
Medical School
Boston Va Hosp
Graduated: 1964
Medical School
New York Hosp
Graduated: 1964
Medical School
Cornell and The New York Hospital
Graduated: 1964
Medical School
Ntnl Institute Of Health MD
Graduated: 1964
Francis Ennis Photo 2

Dr. Francis Ennis, Greenwich CT - MD (Doctor of Medicine)

Specialties:
Orthopedic Surgery
Address:
6 Greenwich Office Park, Greenwich, CT 06831
(203) 869-1145 (Phone)
Certifications:
Orthopedic Surgery, 2007
Awards:
Healthgrades Honor Roll
Languages:
English
Spanish
Hospitals:
Worcester Office
55 Lake Ave N, Worcester, MA 01655
UMass Memorial Medical Center - University Campus
55 Lake Avenue North, Worcester, MA 01655
6 Greenwich Office Park, Greenwich, CT 06831
Greenwich Hospital
5 Perryridge Road, Greenwich, CT 06830
Stamford Hospital
30 Shelburne Road, Stamford, CT 06902
Education:
Medical School
Duke University School Of Medicine
Graduated: 1999
Medical School
Yale New Haven Hospital
Graduated: 2000

Francis A. Ennis

Specialties:
Orthopaedic Surgery
Work:
Orthopaedic & Neurosurgery SpecialistsOrthopaedics & Neurosurgery Specialists
6 Greenwich Office Park, Greenwich, CT 06831
(203) 869-1145 (phone) (203) 869-2170 (fax)
Site
Education:
Medical School
Duke University School of Medicine
Graduated: 1999
Procedures:
Hip Replacement, Hip/Femur Fractures and Dislocations, Knee Replacement, Arthrocentesis, Knee Arthroscopy, Lower Leg/Ankle Fractures and Dislocations, Occupational Therapy Evaluation
Conditions:
Osteoarthritis, Fractures, Dislocations, Derangement, and Sprains, Internal Derangement of Knee, Internal Derangement of Knee Cartilage, Internal Derangement of Knee Ligaments, Intervertebral Disc Degeneration, Lateral Epicondylitis, Plantar Fascitis, Rotator Cuff Syndrome and Allied Disorders, Sciatica, Spinal Stenosis
Languages:
English, Spanish
Description:
Dr. Ennis graduated from the Duke University School of Medicine in 1999. She works in Greenwich, CT and specializes in Orthopaedic Surgery. Dr. Ennis is affiliated with Greenwich Hospital.
Francis Ennis Photo 3

Francis Anthony Ennis, Greenwich CT

Specialties:
Orthopaedic Surgery
Adult Reconstructive Orthopaedic Surgery
Work:
Orthopaedic & Neurosurgery Specialists
6 Greenwich Office Park, Greenwich, CT 06831
Education:
Duke University(1999)
Francis Ennis Photo 4

Francis A Ennis, Worcester MA

Specialties:
Internal Medicine
Infectious Disease
Work:
U Mass Memorial Medical Center
55 Lake Ave N, Worcester, MA 01655
Education:
Tufts University (1964)
Francis Ennis Photo 5

Francis A Ennis, Worcester MA

Specialties:
Internist
Address:
55 Lake Ave N, Worcester, MA 01655
Education:
Tufts University, School of Medicine - Doctor of Medicine
Board certifications:
American Board of Internal Medicine Certification in Internal Medicine
Francis Ennis Photo 6

Francis Ennis, Greenwich CT

Specialties:
Orthopedic Surgeon
Address:
6 Greenwich Office Park, Greenwich, CT 06831
Board certifications:
American Board of Orthopaedic Surgery Certification in Orthopaedic Surgery

Francis Ennis resumes & CV records

Resumes

Francis Ennis Photo 24

Professor Of Medicine And Molecular Genetics And Microbiology

Location:
8 Dialstone Ln, Riverside, CT 06878
Industry:
Research
Work:
Umass Medical School
Professor of Medicine and Molecular Genetics and Microbiology
Cber Fda Dhhs 1973 - 1980
Director Division of Viral Vaccines
Education:
Tufts University School of Medicine 1960 - 1970
Doctor of Medicine, Doctorates, Bachelors, Bachelor of Arts, Medicine
Boston College

Publications & IP owners

Us Patents

Predictive Assay For Immune Response

US Patent:
6627407, Sep 30, 2003
Filed:
Feb 13, 2001
Appl. No.:
09/782709
Inventors:
Francis A. Ennis - Shrewsbury MA
Assignee:
University of Massachusetts Medical Center - Worcester MA
International Classification:
A61K 4900
US Classification:
435 724, 424 92, 435 6
Abstract:
The present invention relates to an in vitro method for determining the ability of a vaccine composition which comprises one or more antigens or a nucleic acid molecule which encodes one or more antigens to stimulate a T cell response. In one embodiment, the method comprises the steps of: (1) contacting antigen presenting cells in culture with a vaccine composition selected from among the group of vaccine compositions, thereby, if one or more of the antigens or nucleic acid molecules can be taken up and processed by the antigen presenting cells, producing one or more processed antigens; (2) contacting the antigen presenting cells with T cells under conditions sufficient for the T cells to respond to one or more of the processed antigens; (3) determining whether the T cells respond to one or more of the processed antigens; whereby if the T cells respond to one or more of the processed antigens, then the vaccine composition stimulates a T cell response; and (4) repeating steps (1), (2) and (3) with each vaccine composition in the group, thereby identifying vaccine compositions which stimulate a T cell response; and, if one or more of the vaccine compositions stimulates a T cell response, (5) selecting at least one vaccine composition which stimulates a T cell response for assessment in one or more animals and/or human subjects.

Predictive Assay For Immune Response

US Patent:
6962790, Nov 8, 2005
Filed:
Sep 23, 1998
Appl. No.:
09/159172
Inventors:
Francis A. Ennis - Shrewsbury MA, US
Assignee:
University of Massachusetts Medical Center - Worcester MA
International Classification:
C12N015/00
US Classification:
435 724, 424 92, 4241991, 4242001, 435 6
Abstract:
The present invention relates to an in vitro method for determining the ability of a vaccine composition which comprises one or more antigens or a nucleic acid molecule which encodes one or more antigens to stimulate a T cell response. In one embodiment, the method comprises the steps of: (1) contacting antigen presenting cells in culture with a vaccine composition selected from among the group of vaccine compositions, thereby, if one or more of the antigens or nucleic acid molecules can be taken up and processed by the antigen presenting cells, producing one or more processed antigens; (2) contacting the antigen presenting cells with T cells under conditions sufficient for the T cells to respond to one or more of the processed antigens; (3) determining whether the T cells respond to one or more of the processed antigens; whereby if the T cells respond to one or more of the processed antigens, then the vaccine composition stimulates a T cell response; and (4) repeating steps (1), (2) and (3) with each vaccine composition in the group, thereby identifying vaccine compositions which stimulate a T cell response; and, if one or more of the vaccine compositions stimulates a T cell response, (5) selecting at least one vaccine composition which stimulates a T cell response for assessment in one or more animals and/or human subjects.

Identification Of Gene Sequences And Proteins Involved In Vaccinia Virus Dominant T Cell Epitopes

US Patent:
7217526, May 15, 2007
Filed:
Jan 26, 2004
Appl. No.:
10/764985
Inventors:
Masanori Terajima - Holden MA, US
John Cruz - Shrewsbury MA, US
Francis A. Ennis - Shrewsbury MA, US
Assignee:
University of Massachusetts Medical School - Worcester MA
International Classification:
G01N 33/53
G01N 33/531
A61K 39/275
A61K 39/285
A61K 38/08
US Classification:
435 71, 530300, 530328, 424 931, 4242321
Abstract:
The present invention relates to the identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes. Two vaccinia virus CD8 T cell epitopes restricted by the most common human MHC class I allele, HLA-A0201 have been identified. Both epitopes are highly conserved in vaccinia and variola viruses. The induction of the T cell responses following primary vaccination is demonstrated by the kinetics of epitope specific CD8 T cells in 3 HLA-A0201 individuals. This information will be useful for the design and analyses of the immunogenicity of experimental vaccinia vaccines, and for basic studies of human T cell memory.

Predictive Assay For Immune Response

US Patent:
7387882, Jun 17, 2008
Filed:
May 13, 2005
Appl. No.:
11/129223
Inventors:
Francis A. Ennis - Shrewsbury MA, US
Assignee:
University of Massachusetts Medical Center - Worcester MA
International Classification:
A61K 39/00
G01N 33/53
US Classification:
435 724, 424 92, 4241841
Abstract:
The present invention relates to an in vitro method for determining the ability of a vaccine composition which comprises one or more antigens or a nucleic acid molecule which encodes one or more antigens to stimulate a T cell response. In one embodiment, the method comprises the steps of: (1) contacting antigen presenting cells in culture with a vaccine composition selected from among the group of vaccine compositions, thereby, if one or more of the antigens or nucleic acid molecules can be taken up and processed by the antigen presenting cells, producing one or more processed antigens; (2) contacting the antigen presenting cells with T cells under conditions sufficient for the T cells to respond to one or more of the processed antigens; (3) determining whether the T cells respond to one or more of the processed antigens; whereby if the T cells respond to one or more of the processed antigens, then the vaccine composition stimulates a T cell response; and (4) repeating steps (1), (2) and (3) with each vaccine composition in the group, thereby identifying vaccine compositions which stimulate a T cell response; and, if one or more of the vaccine compositions stimulates a T cell response, (5) selecting at least one vaccine composition which stimulates a T cell response for assessment in one or more animals and/or human subjects.

Identification Of Gene Sequences And Proteins Involved In Vaccinia Virus Dominant T Cell Epitopes

US Patent:
7803566, Sep 28, 2010
Filed:
Mar 30, 2007
Appl. No.:
11/731784
Inventors:
Masanori Terajima - Holden MA, US
John Cruz - Shrewsbury MA, US
Francis A. Ennis - Shrewsbury MA, US
Assignee:
The University of Massachusetts - Boston MA
International Classification:
G01N 33/53
C07K 5/00
US Classification:
435 724, 435 41, 435 42, 435 2, 435 3, 530300, 530328
Abstract:
The present invention relates to the identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes. Two vaccinia virus CD8 T cell epitopes restricted by the most common human MHC class I allele, HLA-A0201 have been identified. Both epitopes are highly conserved in vaccinia and variola viruses. The induction of the T cell responses following primary vaccination is demonstrated by the kinetics of epitope specific CD8 T cells in 3 HLA-A0201 individuals. This information will be useful for the design and analyses of the immunogenicity of experimental vaccinia vaccines, and for basic studies of human T cell memory.

Identification Of Gene Sequences And Proteins Involved In Vaccinia Virus Dominant T Cell Epitopes

US Patent:
8067535, Nov 29, 2011
Filed:
Sep 28, 2005
Appl. No.:
11/238122
Inventors:
Masanori Terajima - Holden MA, US
John Cruz - Shrewbury MA, US
Francis A. Ennis - Shrewsbury MA, US
Assignee:
The University of Massachusetts - Boston MA
International Classification:
A61K 38/08
A61K 39/285
US Classification:
530328, 4242321
Abstract:
The present invention relates to the identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes. Three vaccinia virus CD8 T cell epitopes restricted by the most common human M. C. class I allele, HLA-A0201, were identified. Each of these epitopes is highly conserved in vaccinia and variola viruses. In addition, the induction of the T cell responses following primary vaccination with two of these epitopes is demonstrated by the kinetics of epitope specific CD8 T cells in 3 HLA-A0201 individuals. Two vaccinia virus CD8 T cell epitopes restricted by another common human M. C. class I allele, HLA-B7, also were identified. Both epitopes are highly conserved in vaccinia and variola viruses. This information will be useful for the design and analysis of the immunogenicity of experimental vaccinia vaccines, and for basic studies of human T cell memory.

Predictive Assay For Immune Response

US Patent:
2008029, Dec 4, 2008
Filed:
May 21, 2008
Appl. No.:
12/154287
Inventors:
Francis A. Ennis - Shrewsbury MA, US
Assignee:
University of Massachusetts Medical Center - Worcester MA
International Classification:
C12Q 1/02
US Classification:
435 29
Abstract:
The present invention relates to an in vitro method for determining the ability of a vaccine composition which comprises one or more antigens or a nucleic acid molecule which encodes one or more antigens to stimulate a T cell response. In one embodiment, the method comprises the steps of: (1) contacting antigen presenting cells in culture with a vaccine composition selected from among the group of vaccine compositions, thereby, if one or more of the antigens or nucleic acid molecules can be taken up and processed by the antigen presenting cells, producing one or more processed antigens; (2) contacting the antigen presenting cells with T cells under conditions sufficient for the T cells to respond to one or more of the processed antigens; (3) determining whether the T cells respond to one or more of the processed antigens; whereby if the T cells respond to one or more of the processed antigens, then the vaccine composition stimulates a T cell response; and (4) repeating steps (1), (2) and (3) with each vaccine composition in the group, thereby identifying vaccine compositions which stimulate a T cell response; and, if one or more of the vaccine compositions stimulates a T cell response, (5) selecting at least one vaccine composition which stimulates a T cell response for assessment in one or more animals and/or human subjects.

Cross-Reactive Influenza A Immunization

US Patent:
5674502, Oct 7, 1997
Filed:
Jun 5, 1995
Appl. No.:
8/462963
Inventors:
Francis A. Ennis - Shrewsbury MA
Assignee:
University of Massachusetts Medical Center - Worcester MA
International Classification:
A61K 3912
A61K 39145
A61K 3900
A61K 3938
US Classification:
4242061
Abstract:
This disclosure relates to methods and compositions for stimulating in an individual an influenza A virus protective response which is subtype cross-protective. Influenza A virus NS1 protein, or a T cell epitope thereof, is administered to the individual in an amount sufficient to stimulate the virus protective response.

Isbn (Books And Publications)

Human Immunity To Viruses

Author:
Francis A. Ennis
ISBN #:
0122399803

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