Gary J Cleek, Age 5593 Middle Valley Rd, Long Valley, NJ 07853

5981537, Nov 9, 1999

May 9, 1996

8/640898

Richard A. Nugent - Galesburg MI
Stephen T. Schlachter - Kalamazoo MI
Michael J. Murphy - Kalamazoo MI
Joel Morris - Kalamazoo MI
Richard C. Thomas - Kalamazoo MI
Donn G. Wishka - Kalamazoo MI
Fritz Reusser - Portage MI
Gary J. Cleek - Kalamazoo MI
Irene W. Althaus - Portage MI

Pharmacia & Upjohn Company - Kalamazoo MI

A61K 31505
A61K 31535
C07D41300
C07D23902

514274

The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely the compounds of Formula (I) where R. sup. 4 is selected from the group consisting of --H or --NR. sub. 15 R. sub. 16 where R. sub. 15 is --H and R. sub. 16 is --H, C. sub. 1 -C. sub. 6 alkyl, --NH. sub. 2 or R. sub. 15 and R. sub. 16 taken together with the --N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and R. sub. 6 is selected from the group consisting of --H, or halo (preferably --Cl); with the overall proviso that R. sub. 4 and R. sub. 6 are not both --H. The compounds of Formula (IA) are useful in the treatment of individuals who are HIV positive.

6043248, Mar 28, 2000

Oct 17, 1997

8/945153

Richard A. Nugent - Galesburg MI
Stephen T. Schlachter - Boulder CO
Michael J. Murphy - Kalamazoo MI
Joel Morris - Kalamazoo MI
Richard C. Thomas - Kalamazoo MI
Donn G. Wishka - Kalamazoo MI
Gary J. Cleek - Kalamazoo MI
David R. Graber - Kalamazoo MI

Pharmacia & Upjohn Company - Kalamazoo MI

C07D23946
C07D23956
C07D23948
A61K 31505

514256

The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely the compounds of Formula (I) where R. sub. 4 is selected from the group consisitng of --H or --NR. sub. 15 R. sub. 16 where R. sub. 15 is --H and R. sub. 16 is --H, C. sub. 1 -C. sub. 6 alkyl, NH. sub. 2 or R. sub. 15 and R. sub. 16 taken together with the --N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and R. sub. 6 is selected from the group consisting of --H, or halo (preferably --Cl); with the overall proviso that R. sub. 4 and R. sub. 6 are not both --H. The compounds of Formula (IA) are useful in the treatment of individuals who are HIV positive being inhibitors of viral reverse transcriptase. ##STR1##.

5922707, Jul 13, 1999

May 2, 1997

8/850424

Richard C. Thomas - Kalamazoo MI
Gary J. Cleek - Kalamazoo MI
Douglas K. Hutchinson - Kalamazoo MI
Hiroyoshi Yamada - Ibaraki, JP

Pharmacia & Upjohn Company - Kalamazoo MI

A61K 31535

5142302

This invention provides novel oxazolidinone derivatives represented by chemical Formula (I), or pharmaceutically acceptable salts thereof: ##STR1## wherein X is NR. sub. 1, CR. sub. 2 R. sub. 3, O, S, SO, or SO. sub. 2 ; and Z is NR. sub. 4, S, SO, SO. sub. 2 or O. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci and streptococci, as well as anaerobic organisms such as bacteroides and clostridia species, and acid-fast organisms such as Mycobacterium tuberculosis and Mycobacterium avium.

5952324, Sep 14, 1999

May 14, 1997

9/051466

Michael R. Barbachyn - Kalamazoo MI
Richard C. Thomas - Kalamazoo MI
Gary L. Cleek - Kalamazoo MI
Lisa M. Thomasco - Kalamazoo MI
Robert C. Gadwood - Kalamazoo MI

Pharmacia & Upjohn Company - Kalamazoo MI

C07D49148
C07D49108
C07D49504
A61K 3142

514211

Phenyloxazolidinone compound of formula (I)or a pharmaceutically acceptable salt thereof characterized by a bicyclic thiazine or oxazine substituent. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacteroides spp. and Clostridia spp. species, and acid-fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

6069141, May 30, 2000

Feb 3, 1999

9/243871

Michael Robert Barbachyn - Kalamazoo MI
Joel Morris - Kalamazoo MI
Donn G. Wishka - Kalamazoo MI
Gary J. Cleek - Kalamazoo MI
Richard Charles Thomas - Kalamazoo MI

Pharmacia & Upjohn Company - Kalamazoo MI

A61K 31422
A61K 315377
A61N 3104
C07D41310

5142368

The present invention provides novel substituted amionphenyl isoxazoline derivatives of formula I ##STR1## wherein R. sub. 1 is H, alkyl, cycloalkyl, alkoxy, amino, or alkylamino; X and Y are the same and different and are H, F, or CH. sub. 3 ; W is O, or S; Q is a 4-, 5-, 6-, 7-, or 9-membered heterocyclic moiety containing one or more nitrogen, sulfur and/or oxygen. The compounds of the invention are useful as antimicrobial agents for preventing and treating infectious diseases.

5990136, Nov 23, 1999

Aug 15, 1997

8/999753

Michael Robert Barbachyn - Kalamazoo MI
Richard Charles Thomas - Kalamazoo MI
Gary J. Cleek - Kalamazoo MI

Pharmacia & Upjohn Company - Kalamazoo MI

C07D41300
C07D26102
A61K 3144
A61K 3142

514340

The present invention provides compounds of formula 1 ##STR1## or pharmaceutical acceptable salts thereof wherein A and R. sub. 1 are as defined in the claims which are antibacterial agents.

6093736, Jul 25, 2000

Aug 31, 1999

9/386647

Michael Robert Barbachyn - Kalamazoo MI
Richard Charles Thomas - Kalamazoo MI
Gary J. Cleek - Kalamazoo MI

Pharmacia & Upjohn Company

A61K 3144
A61K 3142
C07D41300
C07D26102

514340

The present invention provides compounds of formula I ##STR1## or a pharmaceutical acceptable salt thereof wherein Q, X, Y and R. sub. 1 are as defined in the claims which are antibacterial agents.