George B Blondin DeceasedMadison, WI

George Blondin Phones & Addresses

Madison, WI

1008 Ibis Ct, Dunedin, FL 34698 (727) 734-1654

Mentions for George B Blondin

Publications

Us Patents

Bioassay For Chemicals Which Generate Prooxidant States

US Patent:
5198336, Mar 30, 1993
Filed:
May 8, 1989
Appl. No.:
7/348637
Inventors:
Lynda M. Knobeloch - Madison WI
George A. Blondin - Madison WI
John M. Harkin - Madison WI
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C12Q 126
C12Q 132
G01N 2400
G01N 2100
US Classification:
435 4
Abstract:
A bioassay making use of submitochondrial particles to test for the presence of toxic substances which induce prooxidant states in vivo. The assay uses complex I of the electron transport enzymes on the submitochondrial particles which are capable of donating electrons to the toxicant in solution. The presence of any activated oxygen species in the assay solution is detected spectrophotometrically by the adrenochrome reaction.

Bioassay For Toxic Substances

US Patent:
4808517, Feb 28, 1989
Filed:
Dec 27, 1985
Appl. No.:
6/813686
Inventors:
George A. Blondin - Madison WI
John M. Harkin - Madison WI
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C12Q 100
C12Q 148
C12Q 134
C12Q 126
C12Q 132
US Classification:
435 4
Abstract:
An assay method is disclosed to test for the presence of toxic substances in environmental samples. The assay uses a suspension of mitochondrial membranes carrying enzymes which can be driven by reverse electron transfer to reduce NAD+ to NADH. The competency of the mitochondrial membrane to accomplish this reduction in the presence of the environmental sample is measured spectrophotometrically to test for toxicants.

Bioassay For Toxic Substances Activated By Metabolic Enzyme System

US Patent:
5843696, Dec 1, 1998
Filed:
Nov 1, 1995
Appl. No.:
8/551384
Inventors:
Harry W. Read - Madison WI
Karl Gustavson - Madison WI
George A. Blondin - Madison WI
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C12Q 126
US Classification:
435 25
Abstract:
A method for bioassaying for metabolic activation of toxicants from a xenobiotic compound by a metabolic enzyme system includes incubating the xenobiotic compound with a metabolic enzyme system known to produce toxicants during normal metabolic degradation processes and with a mitochondrial membrane preparation competent for enzymatic electron transfer. The production of a toxicant has a detrimental effect upon the electron transfer activity of the mitochondrial membrane preparation which can readily be assayed by observing changes in concentration of a selected redox indicator.

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