Graham D Simmons, Age 48Philadelphia, PA

2007020, Aug 30, 2007

Jun 21, 2006

11/472167

Scott Diamond - Bala Cynwyd PA, US
Dhaval Gosalia - Lansdale PA, US
Graham Simmons - San Francisco CA, US
Paul Bates - Swarthmore PA, US

A61K 38/05
A61K 38/04
A61K 31/541
A61K 31/55
A61K 31/5377
A61K 31/454
A61K 31/40
A61K 31/397

514018000, 514019000, 514210160, 514217110, 514317000, 514423000, 514478000, 514275000, 514235200, 514253130, 514254010

The instant invention is drawn to methods useful for the treatment or the prevention of a viral infection. The methods include administering at least one compound that is an inhibitor of cathepsin L to an individual. The methods are particularly useful in individuals infected with, or at risk of infection with, SARS virus or Ebola virus. The invention also includes methods of identifying potential therapeutics for use in the methods of treatment or prevention of a viral infection.

2016014, May 26, 2016

Jul 21, 2014

14/441867

- Philadelphia PA, US
- San Francisco CA, US
Kristen KAHLE - Philadelphia PA, US
Graham SIMMONS - San Francisco CA, US

C07K 16/10

Embodiments disclosed herein provide for antibodies, including neutralizing antibodies, against Chikungunya virus, uses thereof, and methods of identifying antibodies, including neutralizing antibodies, against Chikungunya virus. In some embodiments, antibodies that binds to a CHIKV antigen, wherein the antigen is the CHIKV E1, E2, E3 protein, or any heterocomplex thereof are provided. In some embodiments, the antibody is an isolated antibody, a neutralizing antibody, a recombinant antibody, or any combination thereof. In some embodiments, the antibodies described herein bind to an epitope of E2 Domain A, E2 Domain B, or E1 Domain II of the CHIKV antigen. In some embodiments, the antigen is E2 protein.