Inventors:
Joseph S. Adorante - Irvine CA
Elizabeth WoldeMussie - Laguna Niguel CA
Guadalupe Ruiz - Corona CA
International Classification:
A61K 31195
Abstract:
Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains, as the active ingredient, one or more compounds having chloride channel blocking activity. Examples of chloride channel blockers utilized in the pharmaceutical composition and method of treatment are: ##STR1## wherein R is hydrogen or a pharmaceutically-acceptable cation, e. g. an alkali or alkaline earth metal, or a quaternary amine; or R represents a ester-forming moiety, e. g. a lower alkyl radical, having up to six carbon atoms, that may be derived from a lower alkanol.