Harish C Pant, Age 86Green Oaks, IL

Harish Pant Phones & Addresses

Lake Forest, IL

37 James St, Woods Hole, MA 02543

11628 Brandy Hall Ln, Gaithersburg, MD 20878

North Potomac, MD

11840 Dinwiddie Dr, Rockville, MD 20852 (269) 547-8848

11846 Dinwiddie Dr, Rockville, MD 20852

Catonsville, MD

11840 Dinwiddie Dr, Rockville, MD 20852

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Us Patents

Therapeutic Approach To Neurodegenerative Disorders Using A Tfp5-Peptide

US Patent:
2012011, May 10, 2012
Filed:
Sep 29, 2011
Appl. No.:
13/249003
Inventors:
Harish C. Pant - Rockville MD, US
Ya-li Zheng - Yinchuan City, CN
Niranjana D. Amin - Clarksburg MD, US
Philip Grant - Washington DC, US
Parvathi Rudrabhatla - Washington DC, US
Varsha Shukla - Rockville MD, US
Sashi Kesavapany - Singapore, SG
International Classification:
A61K 38/17
C12N 15/62
A61P 25/16
A61P 25/00
A61P 25/28
C07K 19/00
C12N 5/0793
US Classification:
514 178, 530324, 514 177, 536 234, 435375
Abstract:
Disclosed herein are isolated peptides, pharmaceutical compositions and methods for use of such for treating subjects with a neurodegenerative disease, such as Alzheimer's. In an example, an isolated polypeptide includes a cyclin dependent kinase 5 (Cdk5) inhibitory domain that has at least 95% sequence identity to the amino acid sequence set forth as SEQ ID NO: 1, wherein the Cdk5 inhibitory domain is linked to a protein transduction domain. Methods of reducing or inhibiting one or more symptoms associated with a neurodegenerative disease by administering a therapeutically effective amount of a pharmaceutical composition including one or more disclosed peptides are also provided.

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