Herb Bull resumes & CV records
Resumes
Herb G Bull, Age 79649 Maple St, Westfield, NJ 07090
Herb Bull Phones & Addresses
649 Maple St, Westfield, NJ 07090 (908) 232-8685
Union, NJ
234 Jefferson Ave, Westfield, NJ 07090 (908) 232-8685
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Mentions for Herb G Bull
Publications & IP owners
Us Patents
Affinity Chromatography Matrix Useful In Purifying Interleukin-1.Beta. Converting Enzyme
US Patent:
5278061, Jan 11, 1994
Filed:
Aug 16, 1991
Appl. No.:
7/746685
Inventors:
Herb G. Bull - Westfield NJ
Kevin T. Chapman - Scotch Plains NJ
Kevin T. Chapman - Scotch Plains NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C12N 948
A23J 100
A23J 100
US Classification:
435212
Abstract:
Affinity chromatography matrices are disclosed which are useful in purifying interleukin-1. beta. converting enzyme (ICE) from crude or partially purified cell lysate preparations. The chromatographic matrices comprise a specific ICE inhibitor of Formula I which is attached to an affinity column support by means of a bifunctional spacer. ##STR1##.
Treatment Of Hyperandrogenic Conditions
US Patent:
5756480, May 26, 1998
Filed:
Oct 24, 1996
Appl. No.:
8/738546
Inventors:
Herb G. Bull - Westfield NJ
Georgianna Harris - Tinton Falls NJ
Robert W. Myers - Cresskill NJ
Georgianna Harris - Tinton Falls NJ
Robert W. Myers - Cresskill NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07H 1904
C07H 19048
A61K 31705
C07H 19048
A61K 31705
US Classification:
514 47
Abstract:
The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5. alpha. -reductase enzymes from 3-oxo-4-oxa end 4-thiasteroids having a 1,2-double bond and the pyridine-nucleotide cofactor of the 5. alpha. -reductase enzyme, NADPH. The invention further relates to the isolated inhibitor-cofactor complex.
Irreversible Inhibition Of Human 5.Alpha.-Reductase
US Patent:
5962442, Oct 5, 1999
Filed:
May 5, 1997
Appl. No.:
8/836341
Inventors:
Herb G. Bull - Westfield NJ
Georgianna S. Harris - Tinton Falls NJ
Georgianna S. Harris - Tinton Falls NJ
Assignee:
Merck & Co., INc. - Rahway NJ
International Classification:
A01N 4500
US Classification:
514169
Abstract:
The invention concerns the treatment of hyderandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5. alpha. -reductase enzymes from 3-oxo-4-azasteroids having a 1,2-double bond and the pyridine-nucleotide cofactor of the 5. alpha. -reductase enzyme, NADPH. Until the present invention, it was not know or predicted that 3-oxo-4-azasteroids having 1,2-double bond would form a complex with NADPH by the mechanism of 5. alpha. -reductase in vivo. The invention further relates to the novel inhibitor-cofactor complex and pharmaceutical compositions containing the complex.
Treatment Of Hyperandrogenic Conditions
US Patent:
5656613, Aug 12, 1997
Filed:
Jan 4, 1995
Appl. No.:
8/368513
Inventors:
Herb G. Bull - Westfield NJ
Georgianna S. Harris - Tinton Falls NJ
Georgianna S. Harris - Tinton Falls NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 3170
US Classification:
514 47
Abstract:
The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5. alpha. -reductase enzymes from 3-oxo-4-azasteroids having a 1,2-double bond and the pyridine-nucleotide cofactor of the 5. alpha. -reductase enzyme, NADPH. Until the present invention, it was not known or predicted that 3-oxo-4-azasteroids having a 1,2-double bond would form a complex with NADPH by the mechanism of 5. alpha. -reductase in vivo. The invention further relates to the novel inhibitor-cofactor complex and pharmaceutical compositions containing the complex.
Treatment Of Hyperandrogenic Conditions
US Patent:
5932559, Aug 3, 1999
Filed:
Apr 23, 1998
Appl. No.:
9/051948
Inventors:
Herb G. Bull - Westfield NJ
Georgianna Harris - Tinton Falls NJ
Robert W. Myers - Cresskill NJ
Georgianna Harris - Tinton Falls NJ
Robert W. Myers - Cresskill NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31505
C07D47102
C07D47102
US Classification:
514 47
Abstract:
The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5. alpha. -reductase enzymes from 3-oxo-4-oxa and 4-thiasteroids having a 1,2-double bond and the pyridine-nucleotide cofactor of the 5. alpha. -reductase enzyme, NADPH. The invention further relates to the isolated inhibitor-cofactor complex.
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