Horace B Fletcher DeceasedIronia, NJ

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Ironia, NJ

Somerset, NJ

Somerville, NJ

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Horace Fletcher

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Horace Fletcher

Horace Fletcher (18491919) was an American health-food faddist of the Victorian era who earned the nickname "The Great Masticator," by arguing that food should be chewed thirty two ...

Us Patents

Branched Adamantyl And Noradamantyl Aryl-And Aralkylpiperazines With Serotonin 5-Ht 1A Activity

US Patent:
2004016, Aug 19, 2004
Filed:
Feb 20, 2004
Appl. No.:
10/783109
Inventors:
Wayne Childers - New Hope PA, US
Horace Fletcher - Pottstown PA, US
Magid Abou-Gharbia - Exton PA, US
John Yardley - King of Prussia PA, US
Assignee:
Wyeth - Madison NJ
International Classification:
C 07D 4 3/02
US Classification:
544/238000, 544/294000, 544/360000, 544/380000
Abstract:
This invention provides compounds and methods using them to provide neuroprotection and prevent or limit processes of neurodegeneration in mammals, including Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, AIDS dementia, retinal disease, diabetic peripheral neuropathy, multiple sclerosis, stroke, acute thromboembolic stroke, focal ischemia, global ischemia, transient ischemic attack, ischemia resulting from surgery, head trauma, spinal trauma, hypoxia, fetal hypoxia, and neuroprotection., the compounds having the structure: wherein X is —CH— or a bond; Y is —(CH)m— or —(CH)—O—(CH)—; m 0 or 1; n is 0 or 1; Rand Rare independently selected from optionally substituted aryl or heteroaryl; the optical isomers and the pharmaceutically acceptable salts thereof.

Benzimidazole Phosphono-Amino Acids

US Patent:
5124319, Jun 23, 1992
Filed:
Oct 11, 1991
Appl. No.:
7/776528
Inventors:
Reinhardt B. Baudy - Yardley PA
Horace Fletcher - Pottstown PA
John P. Yardley - Gulph Mills PA
Assignee:
American Home Products Corporation - New York NY
International Classification:
C07D23515
A61K 31415
US Classification:
514 80
Abstract:
The compounds of the formula ##STR1## wherein R is hydrogen, lower alkyl, benzyl or pivaloyloxymethyl; R. sup. 1 and R. sup. 2 are, independently, hydrogen, lower alkyl, lower alkoxy, trifluoromethyl, trifluoromethoxy, methanesulfonylamino, acetylamino, or halo, or when taken together R. sup. 1 and R. sup. 2 represent a methylenedioxy grouping; and the pharmacologically acceptable salts thereof are NMDA antagonists useful in the treatment and prevention of central nervous system related pathological conditions resulting from overstimulation by excitatory amino acids.

Isbn (Books And Publications)

Menitculture Or The A-B-C Or True Living, 1896

Author:
Horace Fletcher
ISBN #:
0766104893

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