Inventors:
Wayne Childers - New Hope PA, US
Horace Fletcher - Pottstown PA, US
Magid Abou-Gharbia - Exton PA, US
John Yardley - King of Prussia PA, US
International Classification:
C 07D 4 3/02
US Classification:
544/238000, 544/294000, 544/360000, 544/380000
Abstract:
This invention provides compounds and methods using them to provide neuroprotection and prevent or limit processes of neurodegeneration in mammals, including Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, AIDS dementia, retinal disease, diabetic peripheral neuropathy, multiple sclerosis, stroke, acute thromboembolic stroke, focal ischemia, global ischemia, transient ischemic attack, ischemia resulting from surgery, head trauma, spinal trauma, hypoxia, fetal hypoxia, and neuroprotection., the compounds having the structure: wherein X is —CH— or a bond; Y is —(CH)m— or —(CH)—O—(CH)—; m 0 or 1; n is 0 or 1; Rand Rare independently selected from optionally substituted aryl or heteroaryl; the optical isomers and the pharmaceutically acceptable salts thereof.