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Ian M Slaymaker, Age 41Cambridge, MA

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Cambridge, MA

Los Angeles, CA

San Diego, CA

Hope, ME

Rockport, ME

Gorham, ME

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Resumes

Ian Slaymaker Photo 6

Student

Location:
Los Angeles, CA
Ian Slaymaker Photo 7

Student At University Of Southern California

Position:
Student at University of Southern California
Location:
Greater Los Angeles Area
Industry:
Research
Work:
University of Southern California
Student
Ian Slaymaker Photo 8

Ian Slaymaker

Publications & IP owners

Us Patents

Compositions And Methods For Treating Alpha-1 Antitrypsin Deficiency

US Patent:
2023010, Mar 30, 2023
Filed:
Feb 13, 2020
Appl. No.:
17/430665
Inventors:
- Cambridge MA, US
Michael PACKER - Cambridge MA, US
Bernd ZETSCHE - Cambridge MA, US
Ian SLAYMAKER - Cambridge MA, US
Yi YU - Cambridge MA, US
David A. BORN - Cambridge MA, US
Seung-Joo LEE - Cambridge MA, US
Assignee:
BEAM THERAPEUTICS INC. - Cambridge MA
International Classification:
A61K 35/407
A61K 48/00
A61K 38/46
A61K 31/7088
C12N 15/11
C12N 9/22
C12N 9/78
C12N 15/10
C12N 5/071
Abstract:
The present invention features compositions and methods for editing deleterious mutations associated with alpha-1 anti-trypsin (A1AT) deficiency. In particular embodiments, the invention provides methods for correcting mutations in an A1AT polynucleotide using an adenosine deaminase base editor, ABE8, having unprecedented levels of efficiency.

Modified Immune Cells Having Adenosine Deaminase Base Editors For Modifying A Nucleobase In A Target Sequence

US Patent:
2023008, Mar 16, 2023
Filed:
Feb 13, 2020
Appl. No.:
17/430676
Inventors:
- Cambridge MA, US
Michael PACKER - Cambridge MA, US
Ian SLAYMAKER - Cambridge MA, US
Yi YU - Cambridge MA, US
Bernd ZETSCHE - Cambridge MA, US
David A. BORN - Cambridge MA, US
Seung-Joo LEE - Cambridge MA, US
Jason M. GEHRKE - Cambridge MA, US
Assignee:
BEAM THERAPEUTICS INC. - Cambridge MA
International Classification:
C12N 15/113
C12N 9/22
C12N 9/78
Abstract:
The present invention features genetically modified immune cells comprising novel adenosine base editors (e.g., ABE8) having enhanced anti-neoplasia activity, resistance to immune suppression, and decreased risk of eliciting a graft-versus-host reaction or host-versus-graft reaction, or a combination thereof. The present invention also features methods for producing and using these modified immune effector cells.

Novel Crispr Enzymes And Systems

US Patent:
2023007, Mar 9, 2023
Filed:
Dec 17, 2021
Appl. No.:
17/554314
Inventors:
- Cambridge MA, US
Omar O. ABUDAYYEH - Cambridge MA, US
Ian SLAYMAKER - Cambridge MA, US
Assignee:
The Broad Institute, Inc. - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA
President and Fellows of Harvard College - Cambridge MA
International Classification:
C12Q 1/6832
C12N 15/11
C12N 9/22
C12N 15/113
C12Q 1/6816
Abstract:
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed.

Nucleic Acid Assemblies For Use In Targeted Delivery

US Patent:
2021031, Oct 14, 2021
Filed:
Sep 6, 2019
Appl. No.:
17/273999
Inventors:
- Cambridge MA, US
Rémi Veneziano - Cambridge MA, US
Mark Bathe - Cambridge MA, US
Ian Slaymaker - Cambridge MA, US
Bernd Zetsche - Cambridge MA, US
International Classification:
C12N 15/88
C12N 15/11
C12N 9/22
A61K 9/51
Abstract:
Disclosed are compositions and methods involving nucleic acid assemblies that enclose and/or protect cargo. Disclosed are compositions that include a nucleic acid assembly comprising one or more nucleic acid molecules and cargo comprising two or more cargo molecules. The nucleic acid assembly can have physiochemical properties that: (i) enhance targeting of the composition to one or more types of cells, tissues, organs, or microenvironments relative to other types of cells, tissues, organs, or microenvironments in vivo; (ii) enhance stability and/or half-life of the composition in vivo; and/or (iii) reduce immunogenicity of the composition. The nucleic acid assembly and/or cargo can have features that enhance intracellular trafficking of nucleic acid assembly and/or its cargo. The cargo can be enclosed and/or protected by the nucleic acid assembly. Some or all of the cargo molecules in the composition can be present in a defined stoichiometric ratio.

Novel Cas12B Enzymes And Systems

US Patent:
2021016, Jun 3, 2021
Filed:
Aug 7, 2019
Appl. No.:
17/265910
Inventors:
- Cambridge MA, US
Ian Slaymaker - Cambridge MA, US
Sara Jones - Cambridge MA, US
Assignee:
THE BROAD INSTITUTE, INC. - Cambridge MA
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
International Classification:
C12N 15/113
C12N 9/22
C07K 14/32
Abstract:
The disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting Cas12b effector protein and at least one targeting nucleic acid component like a guide RNA or crRNA.

Novel Crispr Enzymes And Systems

US Patent:
2021015, May 27, 2021
Filed:
Apr 19, 2017
Appl. No.:
16/095170
Inventors:
Feng ZHANG - Cambridge MA, US
Bernd ZETSCHE - Gloucester MA, US
Linyi GAO - Cambridge MA, US
Ian SLAYMAKER - Cambridge MA, US
David Benjamin Turitz COX - Cambridge MA, US
- Cambridge MA, US
International Classification:
C12N 9/22
C12N 15/11
C12N 15/90
Abstract:
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Aspects of the invention in particular relate to Cpf1 mutants having altered PAM specificity.

Systems, Methods, And Compositions For Targeted Nucleic Acid Editing

US Patent:
2021013, May 6, 2021
Filed:
Oct 23, 2018
Appl. No.:
16/756139
Inventors:
- Cambridge MA, US
Omar Abudayyeh - Cambridge MA, US
Ian Slaymaker - Cambridge MA, US
Assignee:
THE BROAD INSTITUTE, INC. - Cambridge MA
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA
International Classification:
C12N 9/22
C12N 15/11
A61K 9/50
C12N 9/78
A61P 43/00
Abstract:
The present disclosure provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the present disclosure provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.

Adenosine Deaminase Base Editors And Methods Of Using Same To Modify A Nucleobase In A Target Sequence

US Patent:
2021013, May 6, 2021
Filed:
Dec 18, 2020
Appl. No.:
17/127630
Inventors:
- Cambridge MA, US
Michael PACKER - Cambridge MA, US
Ian SLAYMAKER - Cambridge MA, US
Yi YU - Cambridge MA, US
Bernd ZETSCHE - Cambridge MA, US
Jason Michael GEHRKE - Cambridge MA, US
Natalie PETROSSIAN - Cambridge MA, US
Angelica MESSANA - Cambridge MA, US
Yvonne ARATYN - Cambridge MA, US
Francine GREGOIRE - Cambridge MA, US
Genesis LUNG - Cambridge MA, US
Shaunna BERKOVITCH - Cambridge MA, US
David A. BORN - Cambridge MA, US
Seung-Joo LEE - Cambridge MA, US
Assignee:
Beam Therapeutics Inc. - Cambridge MA
International Classification:
C12N 9/78
C12N 9/22
C12N 15/11
A61P 43/00
Abstract:
The disclosure provides compositions comprising novel adenosine base editors (e.g., ABE8) that have increased efficiency and methods of using these adenosine deaminase variants for editing a target sequence.

Possible Relatives

Kyle Slaymaker  Lisa A Slaymaker  Scott R Slaymaker  Carol Slaymaker  Ian S Johnston  Ian Jolly  Ian D Jones  Ian M Stanley  Ian Stanton  Ian A Stark 

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