Isaac A Manke, Age 471249 Burke Ave, Saint Paul, MN 55109
Isaac Manke Phones & Addresses
1249 Burke Ave, Saint Paul, MN 55109
Vadnais Heights, MN
San Juan, PR
20 Exchange Plz, New York, NY 10005
Cambridge, MA
Boston, MA
River Falls, WI
Moorhead, MN
Somerville, MA
Mentions for Isaac A Manke
Publications & IP owners
Us Patents
Products And Processes For Modulating Peptide-Peptide Binding Domain Interactions
US Patent:
2005019, Sep 8, 2005
Filed:
Nov 14, 2003
Appl. No.:
10/713978
Inventors:
Michael Yaffe - West Roxbury MA, US
Andrew Elia - Boston MA, US
Peter Rellos - Herts, GB
Lewis Cantley - Cambridge MA, US
Stephen Smerdon - London, GB
Isaac Manke - Cambridge MA, US
Andrew Elia - Boston MA, US
Peter Rellos - Herts, GB
Lewis Cantley - Cambridge MA, US
Stephen Smerdon - London, GB
Isaac Manke - Cambridge MA, US
International Classification:
G01N033/53
US Classification:
435007100, 702019000
Abstract:
The present invention relates to therapeutic compounds and methods of use of these therapeutic compounds for treating cellular proliferative disorders. The invention also provides three-dimensional structures of a Polo-like kinase and methods for designing or selecting small molecule inhibitors using these structures, and the therapeutic use of such compounds. The invention also includes a method for identifying novel phosphopeptide-binding domains.
Methods And Compositions For Cancer Treatment Relating To Brca1 Brct Domain Recognition Of Phosphorylated Bach1
US Patent:
2006005, Mar 9, 2006
Filed:
May 9, 2005
Appl. No.:
11/126022
Inventors:
Michael Yaffe - West Roxbury MA, US
Julie Clapperton - London, GB
Isaac Manke - Cambridge MA, US
Drew Lowery - Cambridge MA, US
Stephen Smerdon - London, GB
Julie Clapperton - London, GB
Isaac Manke - Cambridge MA, US
Drew Lowery - Cambridge MA, US
Stephen Smerdon - London, GB
International Classification:
G06F 19/00
US Classification:
702027000
Abstract:
The present invention relates to compounds (e.g., peptidomimetics and non-peptides) that treat, prevent, or stabilize cellular proliferative disorders and methods of treating, preventing, or stabilizing such disorders. The invention also provides three-dimensional structures of a BRCT domain-BACH1 phosphopeptide complex.
Methods And Compositions For Treating Cellular Proliferative Diseases
US Patent:
2006011, Jun 1, 2006
Filed:
Nov 14, 2005
Appl. No.:
11/273567
Inventors:
Michael Yaffe - West Roxbury MA, US
Isaac Manke - Cambridge MA, US
Hans Reinhardt - Cambridge MA, US
Daniel Lim - Cambridge MA, US
Isaac Manke - Cambridge MA, US
Hans Reinhardt - Cambridge MA, US
Daniel Lim - Cambridge MA, US
International Classification:
A61K 48/00
A61K 38/21
A61K 38/17
A61K 38/09
A61K 31/7072
A61K 31/522
A61K 31/7048
A61K 31/704
A61K 31/513
A61K 31/4745
A61K 31/407
A61K 31/415
A61K 31/19
A61K 38/21
A61K 38/17
A61K 38/09
A61K 31/7072
A61K 31/522
A61K 31/7048
A61K 31/704
A61K 31/513
A61K 31/4745
A61K 31/407
A61K 31/415
A61K 31/19
US Classification:
424085400, 514002000, 514044000, 514015000, 514171000, 514034000, 514283000, 514263310, 514449000, 514575000, 514049000, 514546000, 514027000, 514269000, 514410000, 514406000
Abstract:
The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, screening assays for identifying such compounds, and methods for treating such disorders.
Mapkap Kinase-2 As A Specific Target For Blocking Proliferation Of P53-Defective Cells
US Patent:
2009001, Jan 8, 2009
Filed:
Apr 24, 2007
Appl. No.:
11/789239
Inventors:
Michael B. Yaffe - West Roxbury MA, US
Isaac A. Manke - New York NY, US
Hans Christian Reinhardt - Cambridge MA, US
Isaac A. Manke - New York NY, US
Hans Christian Reinhardt - Cambridge MA, US
International Classification:
A61K 38/16
A61K 39/395
A61K 38/10
A61K 31/7105
A61K 38/02
A61K 38/08
A61P 35/00
A61K 39/395
A61K 38/10
A61K 31/7105
A61K 38/02
A61K 38/08
A61P 35/00
US Classification:
4241331, 514 12, 514 13, 514 44, 514 2, 514 16
Abstract:
The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, e.g., in patients having one or more p53-deficient cells, screening assays for identifying such compounds, and methods for treating such disorders.
Methods And Compositions For Cancer Treatment Relating To Brca1 Brct Domain Recognition Of Phosphorylated Bach1
US Patent:
2009014, Jun 4, 2009
Filed:
Aug 26, 2008
Appl. No.:
12/229740
Inventors:
Michael B. Yaffe - West Roxbury MA, US
Julie A. Clapperton - London, GB
Isaac A. Manke - Cambridge MA, US
Drew M. Lowery - Cambridge MA, US
Stephen J. Smerdon - London, GB
Lesley F. Haire - London, GB
Julie A. Clapperton - London, GB
Isaac A. Manke - Cambridge MA, US
Drew M. Lowery - Cambridge MA, US
Stephen J. Smerdon - London, GB
Lesley F. Haire - London, GB
International Classification:
G06G 7/58
G01N 31/00
G06F 19/00
G01N 31/00
G06F 19/00
US Classification:
702 27, 703 11
Abstract:
The present invention relates to compounds (e.g., peptidomimetics and non-peptides) that treat, prevent, or stabilize cellular proliferative disorders and methods of treating, preventing, or stabilizing such disorders. The invention also provides three-dimensional structures of a human BRCT domain-BACH1 phosphopeptide complex.
Methods And Compositions For Treating Cellular Proliferative Diseases
US Patent:
2009018, Jul 16, 2009
Filed:
Jul 24, 2008
Appl. No.:
12/220488
Inventors:
Michael B. Yaffe - West Roxbury MA, US
Isaac A. Manke - Cambridge MA, US
Hans Christian Reinhardt - Cambridge MA, US
Daniel Lim - Cambridge MA, US
Isaac A. Manke - Cambridge MA, US
Hans Christian Reinhardt - Cambridge MA, US
Daniel Lim - Cambridge MA, US
International Classification:
G01N 33/566
US Classification:
436501
Abstract:
The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, screening assays for identifying such compounds, and methods for treating such disorders.
Products And Processes For Modulating Peptide-Peptide Binding Domain Interactions
US Patent:
2010003, Feb 4, 2010
Filed:
Aug 27, 2008
Appl. No.:
12/229797
Inventors:
Michael B. Yaffe - West Roxbury MA, US
Andrew E. H. Elia - Boston MA, US
Peter Rellos - Herts, GB
Lewis C. Cantley - Cambridge MA, US
Stephen J. Smerdon - London, GB
Isaac Manke - Cambridge MA, US
Andrew E. H. Elia - Boston MA, US
Peter Rellos - Herts, GB
Lewis C. Cantley - Cambridge MA, US
Stephen J. Smerdon - London, GB
Isaac Manke - Cambridge MA, US
International Classification:
G06G 7/48
G06F 19/00
G06F 19/00
US Classification:
703 11, 702 19
Abstract:
The present invention relates to therapeutic compounds and methods of use of these therapeutic compounds for treating cellular proliferative disorders. The invention also provides three-dimensional structures of a Polo-like kinase and methods for designing or selecting small molecule inhibitors using these structures, and the therapeutic use of such compounds. The invention also includes a method for identifying novel phosphopeptide-binding domains.
Products And Processes For Modulating Peptide-Peptide Binding Domain Interactions
US Patent:
2011010, May 5, 2011
Filed:
Sep 29, 2010
Appl. No.:
12/893957
Inventors:
Michael B. YAFFE - West Roxbury MA, US
Andrew E. H. Elia - Boston MA, US
Peter Rellos - Herts, GB
Lewis C. Cantley - Cambridge MA, US
Stephen J. Smerdon - London, GB
Isaac Manke - Cambridge MA, US
Andrew E. H. Elia - Boston MA, US
Peter Rellos - Herts, GB
Lewis C. Cantley - Cambridge MA, US
Stephen J. Smerdon - London, GB
Isaac Manke - Cambridge MA, US
International Classification:
G01N 33/53
C07K 1/00
G06G 7/48
C07K 1/00
G06G 7/48
US Classification:
435 78, 530333, 703 11
Abstract:
The present invention relates to therapeutic compounds and methods of use of these therapeutic compounds for treating cellular proliferative disorders. The invention also provides three-dimensional structures of a Polo-like kinase and methods for designing or selecting small molecule inhibitors using these structures, and the therapeutic use of such compounds. The invention also includes a method for identifying novel phosphopeptide-binding domains.
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