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James E Bradner, Age 536 Buckskin Dr, Weston, MA 02493

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Known as:
James J Bradner James H Bradner James M Bradner Elizabeth E Bradner Elizabeth J Bradner Jas H Bradner James E Antolini
Related to:
Meghan E Bradner 29

James Bradner Phones & Addresses

295 Meadowbrook Rd, Weston, MA 02493 (617) 549-4786

9 Rollins Ct, Cambridge, MA 02139 (617) 945-5661

695 Euclid Ave, Highland Park, IL 60035 (847) 604-0187 (847) 780-0446

Boston, MA

1459 Milwaukee Ave, Chicago, IL 60622 (773) 384-8613

Philadelphia, PA

Lake Forest, IL

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Work

Company: Brigham and Women's Hospital Address: 75 Francis Street, Boston, MA 02115

Education

School / High School: Pritzker School Of Med University Of Chicago 1999

Languages

English

Awards

Healthgrades Honor Roll

Ranks

Certificate: Hematology, 2006

Mentions for James E Bradner

Career records & work history

Medicine Doctors

James Bradner Photo 1

Dr. James E Bradner, Framingham MA - MD (Doctor of Medicine)

Specialties:
Hematology
Medical Oncology
Oncology
Address:
761 Worcester Rd, Framingham, MA 01701
(508) 788-1700 (Phone)
Certifications:
Hematology, 2006
Internal Medicine, 2002
Medical Oncology, 2005
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
761 Worcester Rd, Framingham, MA 01701
Brigham and Women's Hospital
75 Francis Street, Boston, MA 02115
Massachusetts General Hospital
55 Fruit Street, Boston, MA 02114
North Shore Medical Center - Salem Hospital
81 Highland Avenue, Salem, MA 01970
Education:
Medical School
Pritzker School Of Med University Of Chicago
Graduated: 1999
Medical School
Brigham and Women's Hospital
Graduated: 1999
Medical School
Dana Farber Cancer Institute
Graduated: 1999

James E. Bradner

Specialties:
Hematology/Oncology
Work:
Dana-Farber Cancer Institute Center For Neurology-Oncology
450 Brookline Ave FL 10, Boston, MA 02215
(617) 632-6633 (phone) (617) 632-4773 (fax)
Education:
Medical School
University of Chicago Pritzker School of Medicine
Graduated: 1999
Procedures:
Bone Marrow or Stem Cell Transplant, Chemotherapy
Conditions:
Anemia, Leukemia, Multiple Myeloma, Non-Hodgkin's Lymphoma, Candidiasis, Heart Failure, Hemolytic Anemia, Hodgkin's Lymphoma, Osteomyelitis, Pulmonary Embolism, Venous Embolism and Thrombosis
Languages:
Chinese, English, French, Spanish
Description:
Dr. Bradner graduated from the University of Chicago Pritzker School of Medicine in 1999. He works in Boston, MA and specializes in Hematology/Oncology. Dr. Bradner is affiliated with Boston Childrens Hospital, Brigham & Womens Hospital and MassGeneral For Children At North Shore Medical Center.
James Bradner Photo 2

James Elliott Bradner, Boston MA

Specialties:
Internal Medicine
Hematology
Medical Oncology
Hematology & Oncology
Work:
Dana-Farber Cancer Institute
44 Binney St, Boston, MA 02115Dana-Farber Cancer Institute
450 Brookline Ave, Boston, MA 02215
Education:
University of Chicago (1999)
James Bradner Photo 3

James Elliott Bradner, Boston MA

Specialties:
Internist
Address:
44 Binney St, Boston, MA 02115
Education:
Doctor of Medicine
Board certifications:
American Board of Internal Medicine Sub-certificate in Hematology (Internal Medicine)
American Board of Internal Medicine Sub-certificate in Oncology (Internal Medicine)

James Bradner resumes & CV records

Resumes

James Bradner Photo 15

James Bradner

James Bradner Photo 16

James Bradner

Location:
United States

Publications & IP owners

Us Patents

Method For Preparing Largazole Analogs And Uses Thereof

US Patent:
8217076, Jul 10, 2012
Filed:
Jul 16, 2009
Appl. No.:
12/504508
Inventors:
Robert M. Williams - Fort Collins CO, US
James E. Bradner - Cambridge MA, US
Albert Bowers - Boston MA, US
Tenaya Newkirk - Fort Collins CO, US
Assignee:
Colorado State University Research Foundation - Fort collins CO
Dana-Farber Cancer Institute - Boston MA
International Classification:
A61K 31/24
A61K 31/195
A61K 31/165
C12N 9/99
C07C 229/02
C07C 251/00
C07C 233/88
US Classification:
514539, 514563, 514615, 564158, 560 37, 562440
Abstract:
Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.

Bifunctional Histone Deacetylase Inhibitors

US Patent:
8222423, Jul 17, 2012
Filed:
Feb 14, 2007
Appl. No.:
12/279440
Inventors:
James Elliot Bradner - Cambridge MA, US
Ralph Mazitschek - Arlington MA, US
Tang Weiping - Cambridge MA, US
Stuart S. Schreiber - Boston MA, US
Assignee:
Dana-Farber Cancer Institute, Inc. - Boston MA
President and Fellows of Harvard College - Cambridge MA
Howard Hughes Medical Institute - Chevy Chase MD
International Classification:
C07D 249/00
C07C 303/00
US Classification:
548255, 564 80, 564 84
Abstract:
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel bifunctional, trifunctional, or multifunctional compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e. g. , proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc. ) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.

Histone Deacetylase And Tubulin Deacetylase Inhibitors

US Patent:
8304451, Nov 6, 2012
Filed:
May 2, 2007
Appl. No.:
12/299430
Inventors:
Ralph Mazitschek - Arlington MA, US
Nicholas Paul Kwiatkowski - Auburn MA, US
James Elliot Bradner - Cambridge MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
Dana-Farber Cancer Institute, Inc. - Boston MA
International Classification:
A61K 31/357
C07D 407/12
US Classification:
514452, 549370
Abstract:
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel inhibitors of histone deacetylases, tubulin deacetylases, and/or aggresome inhibitors, and pharmaceutically acceptable salts and derivatives thereof. The inventive compounds fall into two classes—“isotubacin” class and “isoisotubacin” class—all of which include a 1,3-dioxane core. The present invention further provides methods for treating disorders regulated by histone deacetylase activity, tubulin deacetylase activity, and/or the aggresome (e. g. , proliferative diseases, cancer, inflammatory diseases, protozoal infections, protein degradation disorders, protein deposition disorders, etc. ) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.

Histone Deacetylase Inhibitors

US Patent:
8383855, Feb 26, 2013
Filed:
Feb 14, 2007
Appl. No.:
12/279398
Inventors:
James Elliot Bradner - Cambridge MA, US
Ralph Mazitschek - Arlington MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
Dana-Farber Cancer Institute, Inc. - Boston MA
International Classification:
C07C 259/04
A61K 31/47
A61K 31/19
US Classification:
562621, 514307, 514449, 514575
Abstract:
In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors. These compounds include an ester bond making them sensitive to deactivation by esterases. Therefore, these compounds are particularly useful in the treatment of skin disorders. When the compounds reaches the bloodstream, an esterase or an enzyme with esterase activity cleaves the compound into biologically inactive fragments or fragments with greatly reduced activity Ideally these degradation products exhibit a short serum and/or systemic half-life and are eliminated rapidly. These compounds and pharmaceutical compositions thereof are particularly useful in treating cutaneous T-cell lymphoma, neurofibromatosis, psoriasis, hair loss, skin pigmentation, and dermatitis, for example. The present invention also provides methods for preparing compounds of the invention and intermediates thereto.

Reverse Amide Compounds As Protein Deacetylase Inhibitors And Methods Of Use Thereof

US Patent:
8394810, Mar 12, 2013
Filed:
Jan 21, 2011
Appl. No.:
13/010974
Inventors:
John H. van Duzer - Georgetown MA, US
Ralph Mazitschek - Arlington MA, US
Walter Ogier - Winchester MA, US
James E. Bradner - Cambridge MA, US
Guoxiang Huang - Kernersville NC, US
Dejian Xie - Shanghai, CN
Nan Yu - Shanghai, CN
Assignee:
Acetylon Pharmaceuticals - Boston MA
International Classification:
A61K 31/505
US Classification:
514275
Abstract:
The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.

Deacetylase Inhibitors And Uses Thereof

US Patent:
8440716, May 14, 2013
Filed:
Jul 22, 2009
Appl. No.:
13/055241
Inventors:
Weiping Tang - Middleton WI, US
James Elliot Bradner - Cambridge MA, US
Stuart L. Schreiber - Boston MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
Dana-Farber Cancer Institute, Inc. - Boston MA
International Classification:
A61K 31/24
A61K 31/195
A61K 31/165
C07C 229/02
C07C 251/00
C07C 233/88
US Classification:
514539, 514563, 514615, 564158, 560 37, 562440
Abstract:
The present invention provides novel compounds of formula (I) and pharmaceutical compositions thereof. The inventive compounds are useful as deacetylase inhibitors (e. g. , histone deacetylase inhibitors) and may be useful in the treatment of proliferative diseases such as cancer. In particular, the inventive compounds are HDAC6 inhibitors. The invention also provide synthetic methods for preparing the inventive compounds.

Method For Preparing Largazole Analogs And Uses Thereof

US Patent:
8513290, Aug 20, 2013
Filed:
Jun 7, 2012
Appl. No.:
13/490693
Inventors:
Robert M. Williams - Fort Collins CO, US
James E. Bradner - Cambridge MA, US
Albert Bowers - Boston MA, US
Tenaya Newkirk - Fort Collins CO, US
Olaf G. Wiest - Notre Dame IN, US
Assignee:
Colorado State University Research Foundation - Fort Collins CO
Dana-Farber Cancer Institute, Inc. - Boston MA
University of Notre Dame du Lac - Notre Dame IN
International Classification:
A61K 31/429
A61K 31/424
C07D 513/22
C07D 513/18
C07D 498/18
US Classification:
514366, 514374, 514375, 514471, 548122, 548125, 548126, 548215, 548217, 548220
Abstract:
Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.

Reverse Amide Compounds As Protein Deacetylase Inhibitors And Methods Of Use Thereof

US Patent:
8609678, Dec 17, 2013
Filed:
Apr 2, 2012
Appl. No.:
13/437672
Inventors:
John H. Van Duzer - Georgetown MA, US
Ralph Mazitschek - Belmont MA, US
Walter Ogier - Winchester MA, US
James E. Bradner - Cambridge MA, US
Guoxiang Huang - Kernersville NC, US
Dejian Xie - Shanghai, CN
Nan Yu - Shanghai, CN
Assignee:
Acetylon Pharmaceuticals - Boston MA
International Classification:
A01N 43/54
A61K 31/505
C07D 239/42
C07D 401/04
C07D 239/02
US Classification:
514275, 514256, 544332
Abstract:
The present invention relates to “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.

Amazon

James Bradner Photo 18

Carolina Quarterly, Fall 1976 (Volume Xxviii, No. 3)

Author:
Michael (ed.); Boyle, T. Coraghessan; Smith, C. W.; Schwaid, Alfred; Goldwater, Frances; Ardizzone, Tony; Vogan, Sara; Riley, Kathy; Others Carter
Publisher:
University of North Carolina
Binding:
Paperback

Public records

Vehicle Records

James Bradner

Address:
6 Buckskin Dr, Weston, MA 02493
Phone:
(781) 609-2727
VIN:
5FNYF4H57BB086484
Make:
HONDA
Model:
PILOT
Year:
2011

Possible Relatives

Eric C Bradner  John L Bradner  Sue P Bradner  James M Last  James G Stanco  James A Stanczak  James B Standifer  James F Standiford  James S Johnston  James L Stanfield 

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