Inventors:
Dennis ESHIMA - Phoenix AZ, US
Mehmet Husnu - Phoenix AZ, US
Jim Stone - Alpharetta GA, US
Derrick Alcaide - Los Angeles CA, US
Henry Padgett - Dublin OH, US
Joseph E. Zambanini - Delaware OH, US
Thomas A. Klausing - Powell OH, US
Chad E. Bouton - Powell OH, US
Brian C. Kelley - Pataskala OH, US
Scott N. Danhof - Plain City OH, US
David A. Holley - Lancaster OH, US
Jeffrey T. Stroup - Upper Arlington OH, US
James B. Gleeson - Columbus OH, US
Eric Hassenpflug - Westerville OH, US
James A. Prescott - Columbus OH, US
Herman Benecke - Columbus OH, US
Daniel B. Garbark - Blacklick OH, US
Assignee:
CARDINAL HEALTH 414, LLC - Dublin OH
International Classification:
B01J 19/00
B65B 1/00
US Classification:
536 282, 536122, 5483275, 422159, 422119, 422110, 53473
Abstract:
Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutical output; and providing software and hardware controls for overall and sub-portion operation for optional remote data collection, communication, and/or control.
