Inventors:
Jamie Wong - Cambridge MA, US
Brian Bettencourt - Cambridge MA, US
Assignee:
ALNYLAM PHARMACEUTICALS, INC. - Cambridge MA
International Classification:
C12N 15/113
A61K 35/28
US Classification:
424 9321, 536 245, 4353201, 435377, 514 44 A, 424 937
Abstract:
The technology described herein relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the genes encoding negative regulators of MHC expansion (e.g. AhR, Itch, Prox1 and/or SH2B3), and methods of using such dsRNA compositions to inhibit expression of negative regulators of MHC expansion. The use of such compositions to provide, for example, enhanced quantitites and/or qualities of MHCs and/or hematopoietic progenitor cells for transplantation and/or to enhance engraftment of transplanted MHCs hematopoietic progenitor cells is described.