Jennifer N Campbell, Age 458906 Grand Bayou Ct, Tampa, FL 33635

6670606, Dec 30, 2003

Feb 3, 2003

10/356019

Anatoli Verentchikov - Boston MA
Jennifer M. Campbell - Somerville MA

PerSeptive Biosystems, Inc. - Framingham MA

H01J 4900

250287, 250281, 250282, 250284, 250288, 250290, 250291, 250292, 250297, 250397

The use of a segmented-ion trap with collisional damping is disclosed to improve performance (resolution and mass accuracy of single stage and tandem time-of-flight mass spectrometers. In the case of single stage spectrometers ions are directly injected from a pulsed ion source into the trap supplied with RF field and filled with gas at millitorr pressure. Subsequently, the ions are dynamically trapped by an RF-field, cooled in gas collisions and ejected out of the trap by a homogeneous electric field into a time-of-flight mass spectrometer. In the case of tandem mass spectrometric analysis the pulsed ion beam is injected into a time-of-flight analyzer to select ions-of-interest prior to injection into the trap at medium energy to achieve fragmentation in the trap.

6833544, Dec 21, 2004

Apr 1, 2002

09/857234

Jennifer Campbell - Somerville MA
Bruce Collings - Bradford, CA
Donald J. Douglas - Vancouver, CA

University of British Columbia - Vancouver

H01J 4942

250282, 250281, 250284, 250288, 250290, 250423 R, 250423 P

A method of and apparatus for analyzing a stream of ions first subjects astream of ions to a first mass analysis step, to select ions having a mass-to-charge ratio in a first desired range; this enables a mass analyzer with highresolution to be used. The selected ions are then passed into a radiofrequency linear ion trap containing a gas. The trapped ions are caused to collide with the gas, either by being injected with a high axial energy or by application of external excitation to cause fragmentation. Fragment ions of a given mass-to-charge ratio can then be isolated and excited to produce fragments of fragments. This process can be repeated to give multiple steps of mass spectrometry, MS. The fragment ions, and undissociated precursorions are then passed out of the linear ion trap and subjected to a further mass analysis step, for example in a time of flight device, to determine the mass spectrum of the ions.

6900061, May 31, 2005

Aug 23, 2002

10/227088

Igor P. Smirnov - Brookline MA, US
Andrew J. Tomlinson - Wayland MA, US
Lawrence A. Haff - Westborough MA, US
Jennifer M. Campbell - Somerville MA, US
Cheryl E. Murphy - Hudson NH, US

PerSeptive BioSystems, Inc. - Framingham MA
MDS Inc. - Toronto

G01N024/00
H01J049/00

436173, 250288

A sample plate for a MALDI process is provided which comprises an electrically conductive substrate having a hydrophobic coating whose thickness and hydrophobic character can be modified by changing the coating substrate and/or the concentration of the substrate. Different coating substances that have provided optimal performance of the sample plate for reproducible deposition and analysis by MALDI-MS and MALDI-MS/MS processes of analyte mixtures include synthetic waxes such as paraffin compositions, lipids, organic acids, silicon-containing compounds, silica polymers and natural waxes. Metal polishes that have been used to clean and regenerate plate surfaces have also provided a sample plate that has optimal performance for reproducible deposition and analysis by MALDI-MS and MALDI-MS/MS processes of analyte mixtures.

7176454, Feb 13, 2007

May 13, 2005

11/129658

Kevin M. Hayden - Newton NH, US
Marvin Vestal - Framingham MA, US
Jennifer M. Campbell - Somerville MA, US

Applera Corporation - Framingham MA
MDS, Inc. - Concord

H01J 49/00

250288, 250282, 250292, 250287, 25025221, 2502521

Provided are ion sources, methods of forming ions and mass analyzer systems. In various embodiments, the present teachings provide ion sources, methods for focusing ions from an ion source, and methods for operating a time-of-flight mass analyzer. In various embodiments, the present teachings relate to matrix-assisted laser desorption/ionization (MALDI) ion sources and methods of MALDI ion source operation, for use with mass analyzers. In various aspects, provided are ion sources and methods of operation thereof that facilitate increasing one or more of sensitivity and resolution of a TOF mass analyzer configured for multiple modes of operation.

7351959, Apr 1, 2008

May 13, 2005

11/129204

Kevin M. Hayden - Newton NH, US
Marvin L. Vestal - Framingham MA, US
Jennifer M. Campbell - Somerville MA, US

Applera Corporation - Framingham MA
MDS Inc. - Concord, Ontario

H01J 49/16
H01J 49/40

250288, 250282, 250287, 250281

The present teachings relate to MALDI-TOF instruments, instrument components, and methods of operation thereof. In various aspects, the MALDI-TOF instrument can serve and be operated as a MS/MS instrument. In various embodiments, provided are MALDI-TOF instruments, and methods of operating one or more components of a MALDI-TOF instrument, that facilitate one or more of increasing sensitivity, increasing resolution, increasing dynamic mass range, increasing sample support throughput, and decreasing operational downtime.

8598342, Dec 3, 2013

Jun 5, 2009

12/997429

Suzanne Walker Kahne - Brookline MA, US
Jonathan G. Swoboda - Oil City PA, US
Timothy C. Meredith - Plymouth Meeting PA, US
Kyungae Lee - Newton MA, US
Jennifer Campbell - Brighton MA, US

President and Fellows of Harvard College - Cambridge MA

C07D 491/00
C07D 471/00
C07D 413/00
A61K 31/519

544251, 544247, 544115, 5142332, 514257, 514267

The present invention provides Wall Teichoic Acid biosynthesis inhibitors such as compound 1835F03 (targocil) and related synthetic analogs. The invention also provides pharmaceutical compositions thereof and methods for treating bacterial infection and the suppression of growth of bacterial cells by administering a Wall Teichoic Acid biosynthesis inhibitor. The invention is particularly useful for the treatment of Methicillin-resistant (MRSA). The invention further provides procedures for the syntheses of Wall Teichoic Acid biosynthesis inhibitors. The invention also provides methods for the identification of antibacterial therapeutic agents.

6545268, Apr 8, 2003

Apr 10, 2000

09/546465

Anatoli Verentchikov - Boston MA
Jennifer M. Campbell - Somerville MA

PerSeptive Biosystems - Framingham MA

H01J 4926

250287, 250281, 250280

The use of a segmented-ion trap with collisional damping is disclosed to improve performance (resolution and mass accuracy) of single stage and tandem time-of-flight mass spectrometers. In the case of single stage spectrometers ions are directly injected from a pulsed ion source into the trap supplied with RF field and filled with gas at millitorr pressure. Subsequently, the ions are dynamically trapped by an RF-field, cooled in gas collisions and ejected out of the trap by a homogeneous electric field into a time-of-flight mass spectrometer. In the case of tandem mass spectrometric analysis the pulsed ion beam is injected into a time-of-flight analyzer to select ions-of-interest prior to injection into the trap at medium energy to achieve fragmentation in the trap.