Inventors:
Paul Hsien-Fu Wu - Edina MN, US
Catherine E. Taylor - Fridley MN, US
Linnus Cheruiyot - Andover MN, US
Jianwei Li - Woodbury MN, US
Terese A. Bartlett - Forest Lake MN, US
Matt Bergan - Forest Lake MN, US
Assignee:
MEDTRONIC, INC. - Minneapolis MN
International Classification:
A61K 31/695
A61K 31/216
A61K 31/65
A61K 31/496
A61K 31/7048
A61K 31/43
A61K 31/546
A61K 31/407
A61K 31/427
A61K 31/7036
A61K 38/02
A61K 31/28
A61K 31/573
A61K 31/58
C07C 69/92
C07D 307/54
C07D 333/24
C07D 207/337
C07J 5/00
C07J 71/00
C07D 307/42
C07D 333/16
A61P 31/00
A61P 29/00
A61P 9/12
A61P 35/00
A61L 33/00
A61K 31/24
US Classification:
514 23, 514 63, 514534, 514543, 514152, 51425411, 514 29, 514197, 514206, 5142101, 51421015, 514 40, 514495, 514180, 514179, 514174, 560 61, 549501, 549 79, 548562, 552574, 552576, 540 63, 549497, 549 78, 427 224
Abstract:
Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing the compound or reduce the volatility of the compound relative to its counterpart without the leaving group. Nearly any hydrolysable leaving group may be employed. The leaving group may be an agent that may serve a therapeutic function in addition to protecting or retaining the antimicrobial agents.