Jon Stanley Morrow, Age 77Meriden, CT

6485935, Nov 26, 2002

Jan 11, 2000

09/480675

Jon S. Morrow - Madison CT
Prasad Devarajan - New Haven CT
Zhushan Zhang - Hamden CT

Yale University - New Haven CT

C12P 2106

435 691, 435 697, 435189, 435193, 435212, 4352523, 4353201, 536 231, 536 232, 530362, 530364, 530328, 530330

The present invention provides a polypeptide of 26 amino acid residues that comprises the minimal ankyrin binding (MAB) domain. The MAB domain is responsible for the interactions between a Na,K-ATPase and ankyrin. The present invention also provides the three dimensional structure of the MAB domain. Also provided by the present invention are methods for modulating the interaction of a Na,K-ATPase and ankyrin.

6824981, Nov 30, 2004

Aug 13, 2001

09/929266

Brian T. Chait - New York NY
Darin R. Latimer - East Haven CT
Paul M. Lizardi - Wallingford CT
Eric R. Kershnar - New Haven CT
Jon S. Morrow - Madison CT
Matthew E. Roth - Branford CT
Martin J. Mattessich - Woodbridge CT
Kevin J. McConnell - Branford CT

Agilix Corporation - New Haven CT

C12Q 168

435 6, 4352523, 536234, 530300, 530344, 530350, 530412

Disclosed are compositions and methods for sensitive detection of one or multiple analytes. In general, the methods involve the use of special label components, referred to as reporter signals, that can be associated with, incorporated into, or otherwise linked to the analytes. In some embodiments, the reporter signals can be altered such that the altered forms of different reporter signals can be distinguished from each other. In some embodiments, sets of reporter signals can be used where two or more of the reporter signals in a set have one or more common properties that allow the reporter signals having the common property to be distinguished and/or separated from other molecules lacking the common property. In other embodiments, sets of reporter signal/analyte conjugates can be used where two or more of the reporter signal/analyte conjugates in a set have one or more common properties that allow the reporter signal/analyte conjugates having the common property to be distinguished and/or separated form other molecules lacking the common property. Reporter signals can also be in conjunction with analytes (such as in mixtures of reporter signals and analytes), where no significant physical association between the reporter signals and analytes occurs; or alone, where no analyte is present.

2005006, Mar 31, 2005

Apr 14, 2004

10/825568

Brian Chait - New York NY, US
Darin Latimer - East Haven CT, US
Paul Lizardi - Wallingford CT, US
Eric Kershnar - New Haven CT, US
Jon Morrow - Madison CT, US
Matthew Roth - Branford CT, US
Martin Mattessich - Woodbridge CT, US
Kevin McConnell - Branford CT, US

C12Q001/68
G01N033/53
C07H021/04

435006000, 435007100, 536024300, 530350000

Disclosed are compositions and methods for sensitive detection of one or multiple analytes. In general, the methods involve the use of special label components, referred to as reporter signals, that can be associated with, incorporated into, or otherwise linked to the analytes. In some embodiments, the reporter signals can be altered such that the altered forms of different reporter signals can be distinguished from each other. In some embodiments, sets of reporter signals can be used where two or more of the reporter signals in a set have one or more common properties that allow the reporter signals having the common property to be distinguished and/or separated from other molecules lacking the common property. In other embodiments, sets of reporter signal/analyte conjugates can be used where two or more of the reporter signal/analyte conjugates in a set have one or more common properties that allow the reporter signal/analyte conjugates having the common property to be distinguished and/or separated form other molecules lacking the common property. Reporter signals can also be in conjunction with analytes (such as in mixtures of reporter signals and analytes), where no significant physical association between the reporter signals and analytes occurs; or alone, where no analyte is present.

6225086, May 1, 2001

May 21, 1998

9/082059

Jon S. Morrow - Madison CT
Prasad Devarajan - North Haven CT

Yale University - New Haven CT

C12N 1500

435 691

A novel cytoplasmic ankyrin protein is disclosed along with methods for selectively identifying ankyrin proteins that participate in the trafficking of integral membrane proteins and secretory proteins between the endoplasmic reticulum, Golgi and other membrane compartments. Nucleic acid and protein sequences are disclosed, along with methods for identifying agents that modulate the binding of ankyrins to their binding partners.