Joshua Nathan Finger, Age 51254 Stony Run Rd, Spring City, PA 19475

7198911, Apr 3, 2007

Feb 15, 2002

10/077111

C. Gordon Todderud - Newtown PA, US
Joshua Finger - San Marcos CA, US
Jill Rillema - Princeton NJ, US

Bristol-Myers Squibb Company - Princeton NJ

C12P 12/06
C12Q 1/68
C12N 15/63
C07H 21/02
C07H 21/04

435 691, 435 6, 435 911, 4353201, 435455, 536 231, 536 235

The present invention describes a newly discovered polynucleotide encoding a protein involved in the cell signaling cascade, called RET16, cloned, isolated and identified from TNF-alpha stimulated human microvascular endothelial cells, as well as mouse and rat RET16 orthologs thereof. Also described are the RET16 polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the human RET16 protein, and use of the RET16 polynucleotide and polypeptide for therapeutics and diagnostics are described.

7358074, Apr 15, 2008

Jun 2, 2005

11/143984

Donald G. Jackson - Lawrenceville NJ, US
Chandra S. Ramanathan - Ringoes NJ, US
Liana Lee - San Francisco CA, US
Nathan Siemers - Pennington NJ, US
Suzanne J. Suchard - Wilmington DE, US
Joshua Finger - Spring City PA, US
C. Gordon Todderud - Newtown PA, US
Dana Banas - Hamilton NJ, US

Bristol-Myers Squibb Company - Princeton NJ

C12N 9/16
C12N 1/20
C12N 15/63
C12P 21/00
C12P 21/04
C12P 21/06
C07H 21/04

435196, 435 691, 435 697, 435 711, 4352523, 4353201, 536 232

The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

7678887, Mar 16, 2010

Feb 13, 2007

11/705672

Charles G. Todderud - Newtown PA, US
Joshua N. Finger - Spring City PA, US
Jill Rillema - South San Francisco CA, US

Bristol-Myers Squibb Company - Princeton NJ

A61K 51/00
G01N 33/566
C07K 1/00

530350, 424 169, 424 177, 436501

The present invention describes a newly discovered polynucleotide encoding a protein involved in the cell signaling cascade, called RET16, cloned, isolated and identified from TNF-alpha stimulated human microvascular endothelial cells, as well as mouse and rat RET16 orthologs thereof. Also described are the RET16 polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the human RET16 protein, and use of the RET16 polynucleotide and polypeptide for therapeutics and diagnostics are described.

7700574, Apr 20, 2010

Sep 17, 2004

10/944274

Brenda F Baker - Carlsbad CA, US
C. Frank Bennett - Carlsbad CA, US
Kenneth W. Dobie - Del Mar CA, US
Kathleen Myers - Oceanside CA, US
Joshua Finger - San Marcos CA, US
Lex M. Cowsert - San Mateo CA, US

Isis Pharmaceuticals, Inc. - Carlsbad CA

A01N 43/04

514 44, 514 55, 435455, 424 932

Compounds, compositions and methods are provided for modulating the expression of RANKL. The compositions comprise oligonucleotides, targeted to nucleic acid encoding RANKL. Methods of using these compounds for modulation of RANKL expression and for diagnosis and treatment of disease associated with expression of RANKL are provided.

7723479, May 25, 2010

Sep 6, 2007

11/900026

Glen Eugene Mikesell - Pacifica CA, US
Han Chang - Princeton Junction NJ, US
Joshua N. Finger - Spring City PA, US
Guchen Yang - Princeton NJ, US
Robert James Peach - San Diego CA, US
Henry Shen - Princeton NJ, US

Bristol-Myers Squibb Company - Princeton NJ

C07K 14/705

530350

The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

2002009, Jul 18, 2002

Jun 6, 2001

09/875338

Glen Mikesell - Hamilton NJ, US
Han Chang - Princeton Junction NJ, US
Joshua Finger - San Marcos CA, US
Guchen Yang - Morrisvill PA, US
Pin Lu - Cherry Hill NJ, US
Robert Peach - San Diego CA, US

C07K014/705
C07K016/28
C12P021/02
C07H021/04
C12N005/06

530/350000, 530/388220, 536/023500, 435/069100, 435/320100, 435/325000

The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

2002012, Sep 5, 2002

Dec 22, 2000

09/745605

Gary Starling - Lawrenceville NJ, US
Joshua Finger - San Marcos CA, US

C07K016/18
C07H021/04
C12P021/02
C12N005/06

530/388100, 536/023530, 435/326000, 435/320100, 435/069100

The present invention provides the nucleotide and amino acid sequences of apex-1, -2, and -3, encoding novel APEX proteins APEX-1, APEX-2, and APEX-3, which are novel gene members of the CD2 subgroup of the immunoglobulin superfamily.

2003009, May 15, 2003

Mar 22, 2002

10/104943

Joshua Finger - San Marcos CA, US

C12Q001/68
C07H021/04
C12N009/00
C12P021/02
C12N005/06

435/006000, 435/069100, 435/183000, 435/320100, 435/325000, 536/023200

The present invention provides novel polynucleotides encoding APEX4 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of APEX4 polypeptides, APEX4v1 and APEX4sv1, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel APEX4, APEX4v1, and APEX4sv1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.