Juanito John Meneses, Age 76225 Beachview Ave, Sharp Park, CA 94044

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225 Beachview Ave, Pacifica, CA 94044 (650) 355-9234

255 Beachview Ave, Pacifica, CA 94044

West Sacramento, CA

San Francisco, CA

San Jose, CA

Stopover, KY

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Us Patents

Nkx-2.2 And Nkx-6.1 Transgenic Mouse Models For Diabetes, Depression, And Obesity

US Patent:
6127598, Oct 3, 2000
Filed:
Jul 25, 1997
Appl. No.:
8/900510
Inventors:
Michael S. German - San Francisco CA
John L.R. Rubenstein - San Francisco CA
Lori Sussel - San Francisco CA
Maike Sander - San Francisco CA
Roger A. Pedersen - San Francisco CA
Juanito J. Meneses - San Francisco CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C12N 1509
C12N 1563
C12N 1500
C12N 500
US Classification:
800 18
Abstract:
The present invention features mouse models for Nkx-2. 2 gene function and for Nkx-6. 1 gene function, wherein the transgenic mouse is characterized by having a defect in Nkx-2. 2 gene function or a defect in Nkx-6. 1 gene function (where, because Nkx-2. 2 acts upstream of Nkx-6. 1, a defect in Nkx-2. 2 gene function affects Nkx-6. 1 gene function) and by having a decreased number of insulin-producing cells relative to a normal mouse. Where the transgenic mouse contains a defect in Nkx-2. 2 gene function, the mouse is further characterized by a decreased number of serotonin-producing cells relative to a normal mouse. The transgenic mice may be either homozygous or heterozygous for the Nkx-2. 2 or Nkx-6. 1 defect.

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