Karen M Evans, Age 66New Jerusalem, PA

Karen Evans Phones & Addresses

Fleetwood, PA

Reading, PA

Breckenridge, CO

Calabasas, CA

Mobile, AL

Manhattan Beach, CA

Farmington, CT

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Mentions for Karen M Evans

Career records & work history

Lawyers & Attorneys

Karen Evans Photo 1

Karen Sue Evans - Lawyer

Licenses:
Connecticut - Active 1978
Karen Evans Photo 2

Karen Evans - Lawyer

Office:
Law Office of Karen A. Evans
Specialties:
Coverage, Environmental Law, Trusts, Advertising, Trusts, Advertising
ISLN:
907552428
Admitted:
1987
University:
University of California, B.A.
Law School:
Western State University, J.D.
Karen Evans Photo 3

Karen Evans - Lawyer

Specialties:
Family Law
ISLN:
914070151
Admitted:
1994
University:
California St University Long Beach, CA; Western State University College of Law, Fullerton CA
Law School:
Western State College of Law, JD - Juris Doctor, 1994
Karen Evans Photo 4

Karen Evans - Lawyer

Specialties:
Medical Malpractice, Personal Injury
ISLN:
916056856
Admitted:
1990
Law School:
University of North Carolina School of Law, JD - Juris Doctor, 1990
Karen Evans Photo 5

Karen Evans - Lawyer

Office:
Karen Evans Litigation Resolution, Inc.
Specialties:
Alternative Dispute Resolution, Arbitration Law, Business Law, Labor and Employment Law, Mediation Law
ISLN:
907552435
Admitted:
1983
University:
American University, B.A., 1980
Law School:
University of Miami, J.D., 1983

Medicine Doctors

Karen C. Evans

Specialties:
Physical Medicine & Rehabilitation
Work:
Adena Greenfield Medical Center Specialty Clinic
550 Mirabeau St, Greenfield, OH 45123
(937) 981-9261 (phone) (937) 981-9427 (fax)
Adena Medical GroupAdena Bone & Joint Center Chillicothe
4437 State Rte 159, Chillicothe, OH 45601
(740) 779-4598 (phone) (740) 779-4599 (fax)
Site
Adena Greenfield Medical Center Bone & Joint Center
550 Mirabeau St, Greenfield, OH 45123
(937) 981-9280 (phone) (937) 947-9426 (fax)
Adena Medical GroupAdena Bone & Joint Center Washington Court House
308 Highland Ave UNIT C, Washington Court House, OH 43160
(740) 779-4598 (phone) (740) 779-4599 (fax)
Site
Education:
Medical School
Ohio State University College of Medicine
Graduated: 1998
Procedures:
Arthrocentesis, Neurological Testing
Conditions:
Ankylosing Spondylitis (AS), Atrial Fibrillation and Atrial Flutter, Benign Thyroid Diseases, Carpel Tunnel Syndrome, Diabetes Mellitus (DM), Disorders of Lipoid Metabolism, Fractures, Dislocations, Derangement, and Sprains, Hemorrhagic stroke, Hypertension (HTN), Internal Derangement of Knee, Intervertebral Disc Degeneration, Intracranial Injury, Ischemic Stroke, Lateral Epicondylitis, Migraine Headache, Osteoarthritis, Osteoporosis, Peripheral Nerve Disorders, Plantar Fascitis, Restless Leg Syndrome, Rheumatoid Arthritis, Rotator Cuff Syndrome and Allied Disorders, Scoliosis or Kyphoscoliosis, Spinal Stenosis
Languages:
English
Description:
Dr. Evans graduated from the Ohio State University College of Medicine in 1998. She works in Washington Court House, OH and 3 other locations and specializes in Physical Medicine & Rehabilitation. Dr. Evans is affiliated with Adena Greenfield Medical Center, Adena Regional Medical Center and Highland District Hospital.

Karen S. Evans

Specialties:
Family Medicine
Work:
Northeast Medical Associates
1234 E Dupont Rd STE 6, Fort Wayne, IN 46825
(260) 480-2600 (phone) (260) 496-8077 (fax)
Education:
Medical School
Indiana University School of Medicine
Graduated: 1985
Procedures:
Destruction of Benign/Premalignant Skin Lesions, Electrocardiogram (EKG or ECG), Pulmonary Function Tests, Skin Tags Removal, Vaccine Administration
Conditions:
Abnormal Vaginal Bleeding, Acute Conjunctivitis, Alzheimer's Disease, Anxiety Dissociative and Somatoform Disorders, Anxiety Phobic Disorders, Atrial Fibrillation and Atrial Flutter, Breast Disorders, Cardiac Arrhythmia, Chronic Renal Disease, Chronic Sinusitis, Dementia, Diabetes Mellitus (DM), Diverticulitis, Erectile Dysfunction (ED), Gastritis and Duodenitis, Gastroesophageal Reflux Disease (GERD), Gastrointestinal Hemorrhage, Gout, Heart Failure, Herpes Simplex, Herpes Zoster, Hypertension (HTN), Hypothyroidism, Intervertebral Disc Degeneration, Iron Deficiency Anemia, Irritable Bowel Syndrome (IBS), Ischemic Stroke, Menopausal and Postmenopausal Disorders, Metabolic Syndrome, Migraine Headache, Non-Toxic Goiter, Osteoarthritis, Osteoporosis, Peripheral Nerve Disorders, Restless Leg Syndrome, Rheumatoid Arthritis, Sciatica, Vitamin D Deficiency, Abdominal Hernia, Acne, Acute Bronchitis, Acute Pancreatitis, Acute Pharyngitis, Acute Renal Failure, Acute Sinusitis, Acute Upper Respiratory Tract Infections, Allergic Rhinitis, Alopecia Areata, Anal Fissure, Anemia, Angina Pectoris, Appendicitis, Atopic Dermatitis, Attention Deficit Disorder (ADD), Bell's Palsy, Benign Polyps of the Colon, Benign Prostatic Hypertrophy, Bipolar Disorder, Bronchial Asthma, Calculus of the Urinary System, Candidiasis, Candidiasis of Vulva and Vagina, Cardiomyopathy, Carpel Tunnel Syndrome, Cataract, Celiac Disease, Chronic Bronchitis, Chronic Fatigue Syndrome, Chronic Pancreatitis, Congenital Anomalies of the Heart, Constipation, Contact Dermatitis, Depressive Disorders, Dermatitis, Diabetic Peripheral Neuropathy, Disorders of Lipoid Metabolism, Diverticulosis, Emphysema, Epilepsy, Esophagitis, Female Infertility, Fractures, Dislocations, Derangement, and Sprains, Genital HPV, Glaucoma, Hearing Loss, Hemophilia A or B, Hemorrhagic stroke, Hemorrhoids, Herpes Genitalis, Hyperthyroidism, Inflammatory Bowel Disease (IBD), Insomnia, Intestinal Obstruction, Intracranial Injury, Malignant Neoplasm of Female Breast, Mitral Valvular Disease, Multiple Sclerosis (MS), Obsessive-Compulsive Disorder (OCD), Obstructive Sleep Apnea, Otitis Media, Ovarian Dysfunction, Overweight and Obesity, Parkinson's Disease, Paroxysmal Supreventricular Tachycardia (PSVT), Peptic Ulcer Disease, Plantar Fascitis, Plantar Warts, Pneumonia, Poisoning by Drugs, Meds, or Biological Substances, Polycystic Ovarian Syndrome (PCOS), Premenstrual Syndrome (PMS), Psoriasis, Pulmonary Embolism, Rosacea, Rotator Cuff Syndrome and Allied Disorders, Sarcoidosis, Skin and Subcutaneous Infections, Skin Cancer, Spinal Stenosis, Substance Abuse and/or Dependency, Tension Headache, Tinea Pedis, Tinea Unguium, Transient Cerebral Ischemia, Urinary Incontinence, Urinary Tract Infection (UT), Venous Embolism and Thrombosis, Viral Pneumonia
Languages:
English
Description:
Dr. Evans graduated from the Indiana University School of Medicine in 1985. She works in Fort Wayne, IN and specializes in Family Medicine. Dr. Evans is affiliated with duPont Hospital, Lutheran Hospital Of Indiana, Parkview Hospital Randallia and St Joseph Hospital.

Karen F. Evans

Specialties:
Family Medicine
Work:
Mount Oread Family Practice
3510 Clinton Pl STE 210, Laurence, KS 66047
(785) 842-5070 (phone) (785) 505-5096 (fax)
Education:
Medical School
Kansas City University of Medicine and Biosciences College of Osteopathic Medicine
Graduated: 2000
Procedures:
Electrocardiogram (EKG or ECG), Osteopathic Manipulative Treatment, Psychological and Neuropsychological Tests, Skin Tags Removal, Vaccine Administration
Conditions:
Abnormal Vaginal Bleeding, Allergic Rhinitis, Anxiety Dissociative and Somatoform Disorders, Breast Disorders, Bronchial Asthma, Contact Dermatitis, Intervertebral Disc Degeneration, Menopausal and Postmenopausal Disorders, Overweight and Obesity, Skin and Subcutaneous Infections, Substance Abuse and/or Dependency, Abdominal Hernia, Acne, Acute Bronchitis, Acute Conjunctivitis, Acute Pharyngitis, Acute Sinusitis, Acute Upper Respiratory Tract Infections, Alopecia Areata, Alzheimer's Disease, Anemia, Anxiety Phobic Disorders, Atopic Dermatitis, Atrial Fibrillation and Atrial Flutter, Attention Deficit Disorder (ADD), Bipolar Disorder, Candidiasis, Candidiasis of Vulva and Vagina, Cardiac Arrhythmia, Carpel Tunnel Syndrome, Chronic Bronchitis, Chronic Fatigue Syndrome, Chronic Renal Disease, Cirrhosis, Congenital Anomalies of the Heart, Constipation, Dementia, Depressive Disorders, Dermatitis, Diabetes Mellitus (DM), Disorders of Lipoid Metabolism, Eating Disorders, Epilepsy, Erectile Dysfunction (ED), Female Infertility, Fractures, Dislocations, Derangement, and Sprains, Gastritis and Duodenitis, Gastroesophageal Reflux Disease (GERD), Genital HPV, Hemolytic Anemia, Hemorrhoids, Herpes Simplex, Herpes Zoster, Hypertension (HTN), Hyperthyroidism, Hypothyroidism, Inguinal Hernia, Internal Derangement of Knee, Iron Deficiency Anemia, Irritable Bowel Syndrome (IBS), Labyrinthitis, Macular Degeneration, Migraine Headache, Obstructive Sleep Apnea, Osteoarthritis, Osteoporosis, Otitis Media, Peripheral Nerve Disorders, Plantar Warts, Post Traumatic Stress Disorder (PTSD), Prostatitis, Restless Leg Syndrome, Rosacea, Rotator Cuff Syndrome and Allied Disorders, Sciatica, Scoliosis or Kyphoscoliosis, Skin Cancer, Spinal Stenosis, Tempromandibular Joint Disorders (TMJ), Tinea Pedis, Urinary Incontinence, Urinary Tract Infection (UT), Valvular Heart Disease, Varicose Veins, Vitamin D Deficiency
Languages:
English
Description:
Dr. Evans graduated from the Kansas City University of Medicine and Biosciences College of Osteopathic Medicine in 2000. She works in Lawrence, KS and specializes in Family Medicine. Dr. Evans is affiliated with Lawrence Memorial Hospital.

Karen S. Evans

Specialties:
Family Medicine
Work:
Presbyterian Medical GroupPresbyterian Medical Group Kaseman
8300 Constitution Ave NE, Albuquerque, NM 87110
(505) 291-2200 (phone) (505) 291-2233 (fax)
Site
Education:
Medical School
University of New Mexico School of Medicine
Graduated: 1999
Procedures:
Destruction of Benign/Premalignant Skin Lesions, Vaccine Administration, Electrocardiogram (EKG or ECG)
Conditions:
Acute Upper Respiratory Tract Infections, Allergic Rhinitis, Anxiety Dissociative and Somatoform Disorders, Anxiety Phobic Disorders, Bronchial Asthma, Abnormal Vaginal Bleeding, Acne, Acute Bronchitis, Acute Pharyngitis, Acute Sinusitis, Alopecia Areata, Anemia, Atrial Fibrillation and Atrial Flutter, Attention Deficit Disorder (ADD), Benign Paroxysmal Positional Vertigo, Benign Prostatic Hypertrophy, Bipolar Disorder, Breast Disorders, Calculus of the Urinary System, Candidiasis, Candidiasis of Vulva and Vagina, Cardiac Arrhythmia, Chronic Bronchitis, Chronic Sinusitis, Constipation, Contact Dermatitis, Dementia, Depressive Disorders, Dermatitis, Deviated Nasal Septum, Diabetes Mellitus (DM), Diabetic Peripheral Neuropathy, Disorders of Lipoid Metabolism, Diverticulitis, Epilepsy, Erectile Dysfunction (ED), Esophagitis, Fractures, Dislocations, Derangement, and Sprains, Gastritis and Duodenitis, Gastroesophageal Reflux Disease (GERD), Glaucoma, Gout, Hearing Loss, Heart Failure, Hemophilia A or B, Hemorrhoids, Herpes Simplex, Herpes Zoster, Hypertension (HTN), Hyperthyroidism, Hypothyroidism, Inguinal Hernia, Insomnia, Intervertebral Disc Degeneration, Iron Deficiency Anemia, Irritable Bowel Syndrome (IBS), Ischemic Stroke, Malignant Neoplasm of Female Breast, Menopausal and Postmenopausal Disorders, Migraine Headache, Non-Toxic Goiter, Obstructive Sleep Apnea, Osteoarthritis, Osteoporosis, Otitis Media, Overweight and Obesity, Parkinson's Disease, Peptic Ulcer Disease, Peripheral Nerve Disorders, Plantar Warts, Pneumonia, Polycystic Ovarian Syndrome (PCOS), Post Traumatic Stress Disorder (PTSD), Premenstrual Syndrome (PMS), Restless Leg Syndrome, Schizophrenia, Sciatica, Skin and Subcutaneous Infections, Spinal Stenosis, Substance Abuse and/or Dependency, Tension Headache, Transient Cerebral Ischemia, Urinary Incontinence, Urinary Tract Infection (UT), Varicose Veins, Vitamin D Deficiency
Languages:
Arabic, Chinese, English, French, German, Italian, Korean, Polish, Russian, Spanish, Tagalog, Vietnamese
Description:
Dr. Evans graduated from the University of New Mexico School of Medicine in 1999. She works in Albuquerque, NM and specializes in Family Medicine. Dr. Evans is affiliated with Presbyterian Hospital and Presbyterian Kaseman Hospital.

Karen K. Evans

Specialties:
Plastic Surgery
Work:
Medstar Georgetown University Hospital Center/ Wound Healing & Hyperbaric Medicine
3800 Reservoir Rd Nw Bles Bldg, Washington, DC 20007
(202) 444-3059 (phone) (866) 990-5515 (fax)
Education:
Medical School
University of Missouri, Columbia School of Medicine
Graduated: 1999
Languages:
English
Description:
Dr. Evans graduated from the University of Missouri, Columbia School of Medicine in 1999. She works in Washington, DC and specializes in Plastic Surgery. Dr. Evans is affiliated with Medstar Georgetown University Hospital.

Karen W. Evans

Specialties:
Family Medicine
Work:
Green County Health Department
227 Kingold Blvd STE B, Snow Hill, NC 28580
(252) 747-8181 (phone) (252) 747-4040 (fax)
Languages:
English, Spanish
Description:
Ms. Evans works in Snow Hill, NC and specializes in Family Medicine. Ms. Evans is affiliated with Vidant Medical Center.

License Records

Karen Cavender Evans

Licenses:
License #: 18585 - Expired
Issued Date: Jan 27, 1999
Renew Date: May 31, 2000
Expiration Date: May 31, 2000
Type: Certified Public Accountant

Karen M Evans

Licenses:
License #: NA49169 - Active
Category: Nursing Assistant
Issued Date: Aug 18, 2015
Expiration Date: Jun 30, 2017
Type: Nursing Assistant

Publications & IP owners

Wikipedia

Karen Evans Photo 40

Karen S. Evans

Karen S. Evans was the Administrator of the Office of Electronic Government and Information Technology (IT) at the Office of Management and Budget. Evans ...

Us Patents

Substituted 4,5-Dihydro-1,2,4-Triazin-6-Ones, 1,2,4-Triazin-6-Ones And Their Use As Fungicides And Insecticides

US Patent:
2004024, Dec 2, 2004
Filed:
Oct 24, 2003
Appl. No.:
10/380435
Inventors:
Martha Kelly - Collegeville PA, US
Karen Evans - Harleysville PA, US
James Gallagher - Ambler PA, US
Mark Mulvihill - East Northport NY, US
International Classification:
A61K031/53
C 07D 4 9/02
C 07D 4 3/02
US Classification:
514/242000, 544/182000
Abstract:
This invention relates to dihydrotriazinones, triazinones and related compounds, compositions comprising such compounds and an agronomically acceptable carrier, and the use thereof as broad spectrum fungicides and insecticides. This invention also teaches methods of preparing these compounds as well as methods of using the compounds as fungicides and insecticides.

Glycogen Phosphorylase Inhibitor Compounds And Pharmaceutical Compositions Thereof

US Patent:
2007024, Oct 25, 2007
Filed:
Nov 4, 2005
Appl. No.:
11/718804
Inventors:
Karen Evans - Collegeville PA, US
Frank Coppo - Collegeville PA, US
Kate Dwornik - Durham NC, US
Jennifer Gale - Durham NC, US
Dulce Garrido - Durham NC, US
Yue Li - Collegeville PA, US
Mehul Patel - Collegeville PA, US
Francis Tavares - Durham NC, US
Stephen Thomson - Durham NC, US
Scott Dickerson - Durham NC, US
Andrew Peat - Durham NC, US
Steven Sparks - Durham NC, US
Pierette Banker - Durham NC, US
Joel Cooper - Durham NC, US
Assignee:
SMITHKLINE BEECHAM CORPORATION - Philadelphia PA
International Classification:
A61K 31/24
A61K 31/381
A61K 31/40
A61K 31/4164
A61K 31/445
A61K 31/47
C07C 229/72
C07D 207/16
C07D 211/18
C07D 215/38
C07D 233/64
C07D 333/50
US Classification:
514313000, 514319000, 514400000, 514423000, 514438000, 514443000, 514539000, 546162000, 546205000, 548334100, 548533000, 549057000, 560034000
Abstract:
The invention relates to glycogen phosphorylase inhibitor compounds, pharmaceutical compositions of these compounds, methods of treatment using the pharmaceutical compositions to treat diabetes, conditions associated with diabetes, and/or tissue ischemia, including myocardial ischemia, and processes for making the compounds.

Chemical Compounds

US Patent:
2021025, Aug 19, 2021
Filed:
Jul 8, 2019
Appl. No.:
16/973587
Inventors:
- Brentford, Middlesex, GB
Karen Anderson EVANS - Collegeville PA, US
Israil PENDRAK - Collegeville PA, US
Joseph E. PERO - Collegeville PA, US
International Classification:
C07D 213/64
C07C 271/28
C07C 275/30
C07C 235/20
C07D 207/273
A61K 45/06
A61K 31/506
Abstract:
The invention is directed to substituted carbon-linked bicycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (X):

Chemical Compounds As Atf-4 Pathway Inhibitors

US Patent:
2021009, Apr 1, 2021
Filed:
Jun 7, 2018
Appl. No.:
16/619985
Inventors:
- Brentford, Middlesex, GB
Michael P. DEMARTINO - Collegeville PA, US
Karen Anderson EVANS - Collegeville PA, US
Biswajit KALITA - Yeshwanthpur, Bangalore, IN
Jeffrey M. RALPH - Collegeville PA, US
International Classification:
A61K 31/4439
A61K 45/06
C07C 233/41
A61K 31/165
A01N 1/02
C07D 213/65
A61K 31/44
A61K 31/444
C07D 401/12
C07D 305/08
A61K 31/337
A61K 31/4166
C07D 233/36
C07D 207/12
A61K 31/40
C07D 401/04
A61K 31/397
C07D 205/04
A61K 31/343
C07D 307/85
C07D 311/58
A61K 31/353
A61K 31/4035
C07D 209/44
A61K 31/451
C07D 211/18
C07D 401/14
C07D 207/273
C07D 211/46
A61K 9/48
A61K 9/00
A61K 9/20
Abstract:
The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula IIIQ:wherein X, a, b, C, D, L, L, R, R, R, R, R, R, z, z, z, and z are as defined herein; or salts thereof.The compounds of the invention are inhibitors of the ATF4 pathway. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Substituted Pyridines As Inhibitors Of Dnmt1

US Patent:
2019019, Jun 27, 2019
Filed:
Jun 13, 2017
Appl. No.:
16/309121
Inventors:
- Brentford, Middlesex, GB
- London, Greater London, GB
MarĂ­a Lourdes Rueda BENEDE - Collegeville PA, US
Karen Anderson EVANS - Collegeville PA, US
David T. FOSBENNER - Collegeville PA, US
Bryan Wayne KING - Collegeville PA, US
Mei LI - Collegeville PA, US
Juan Ignacio LUENGO - Collegeville PA, US
William Henry MILLER - Collegeville PA, US
Alexander Joseph REIF - Collegeville PA, US
Stuart Paul ROMERIL - Collegeville PA, US
Stanley J. SCHMIDT - Collegeville PA, US
Roger J. BUTLIN - Manchester, GB
Kristen M. GOLDBERG - Manchester, GB
Allan M. JORDAN - Manchester, GB
Christopher S. KERSHAW - Manchester, GB
Ali RAOOF - Manchester, GB
Bohdan WASZKOWYCS - Manchester, GB
International Classification:
C07D 401/12
C07D 417/12
A61P 35/00
A61P 37/00
Abstract:
The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar):wherein Y, X, X, R, R, R, Rand Rare as defined herein; or a pharmaceutically acceptable salt or prodrug thereof.The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Substituted Bridged Urea Analogs As Sirtuin Modulators

US Patent:
2019004, Feb 14, 2019
Filed:
Nov 19, 2015
Appl. No.:
15/527851
Inventors:
- Middlesex, GB
Karen Anderson EVANS - Collegeville PA, US
Ryan Michael FOX - Collegeville PA, US
William Henry MILLER - Collegeville PA, US
Mark Andrew SEEFELD - Collegeville PA, US
International Classification:
C07D 487/18
C07D 519/00
A61P 25/28
A61P 3/10
A61P 9/00
Abstract:
The present invention relates to novel substituted bridged urea analog compounds of Formula (I) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, processes for making and use of such compounds, alone or in combination with other therapeutic agents, as Sirtuin Modulators useful for increasing lifespan of a cell, and in treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.

Substituted Bridged Urea Analogs As Sirtuin Modulators

US Patent:
2018031, Nov 8, 2018
Filed:
Nov 19, 2015
Appl. No.:
15/527941
Inventors:
- Middlesex, GB
Karen Anderson EVANS - Collegeville PA, US
Ryan Michaael FOX - Collegeville PA, US
William Henry MILLER - Collegeville PA, US
Mark Andrew SEEFELD - Collegeville PA, US
International Classification:
C07D 487/18
A61K 31/551
A61K 31/4995
Abstract:
The present invention relates to novel substituted bridged urea analog compounds of Formula (I) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, processes for making and use of such compounds, alone or in combination with other therapeutic agents, as Sirtuin Modulators useful for increasing lifespan of a cell, and in treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.

Substituted Bridged Urea Analogs As Sirtuin Modulators

US Patent:
2017036, Dec 21, 2017
Filed:
Nov 19, 2015
Appl. No.:
15/527581
Inventors:
- Middlesex, GB
Karen Anderson EVANS - Collegeville PA, US
Ryan Michael FOX - Collegeville PA, US
William Henry MILLER - Collegeville PA, US
Mark Andrew SEEFELD - Collegeville PA, US
International Classification:
C07D 471/18
C07D 519/00
A61K 31/5517
Abstract:
The present invention relates to novel substituted bridged urea analog compounds of Formula (I) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, processes for making and use of such compounds, alone or in combination with other therapeutic agents, as Sirtuin Modulators useful for increasing lifespan of a cell, and in treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.

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