Karen L Havenstrite, Age 4115276 Karl Ave, Monte Sereno, CA 95030

2006014, Jun 29, 2006

Dec 28, 2004

11/022862

Victor Rucker - San Francisco CA, US
Renee Shediac - Oakland CA, US
Blake Simmons - San Francisco CA, US
Karen Havenstrite - New York NY, US

C12Q 1/68
G01N 33/53
C12M 1/34

435006000, 435287200, 435007100

Disclosed herein are substrates comprising reactive ion etched surfaces and specific binding agents immobilized thereon. The substrates may be used in methods and devices for assaying or isolating analytes in a sample. Also disclosed are methods of making the reactive ion etched surfaces.

2010005, Mar 4, 2010

Sep 2, 2009

12/552418

Helen M. Blau - Menlo Park CA, US
Karen Havenstrite - Palo Alto CA, US

C12N 13/00
C12N 5/06

4351739, 435378

The disclosure encompasses transparent polymer membranes suitable for use in laser microdissection methods, where the membranes allow the subsequent analysis of the microdissected cell or cells with light of a wavelength that can traverse the membrane with little if any absorbance by the membrane. The transfer capture membranes of the disclosure comprise a polymeric composition having the characteristic of being cut by a laser light at a wavelength less than 360 nm, while being substantially optically transparent at a wavelength greater than about 360 nm. The disclosure further provides methods of isolating a cell or population of cells from a tissue, comprising: overlaying a tissue sample with a transfer capture membrane having the characteristic of being cut by a laser light at a wavelength less than 360 nm, and substantially optically transparent at a wavelength greater than about 360 nm, defining an area of the transfer capture membrane by a laser light cutting through the thickness of the transfer capture membrane and the issue sample; and removing the defined area of the transfer capture membrane with the targeted cell or population of cells adhering thereto.

2012017, Jul 12, 2012

Jul 15, 2011

13/135826

Helen M. Blau - Menlo Park CA, US
Penney M. Gilbert - Menlo Park CA, US
Karen Havenstrite - Menlo Park CA, US
Matthias P. Lutolf - Tolochenaz, CH
Klas Erik Gustaf Magnusson - Nacka, SE
John A. Ramunas - Stanford CA, US

A61K 35/12
G06K 9/62
C12Q 1/02
C12M 3/00
C12N 5/071
C12N 5/0735

424 937, 435325, 435374, 435 29, 4352891, 382133

Methods are provided for the ex vivo manipulation of cells, stem cells and other reproductive cells, by manipulating the cells in a container or device comprising an elastic substrate, wherein the substrate has an elasticity that mimics the elasticity of a native microenvironment of the cell.

2014005, Feb 27, 2014

Aug 26, 2013

13/975868

Karen L. Havenstrite - San Francisco CA, US
Victor Wayne McCray - Fresno CA, US
Brandon McNary Felkins - Half Moon Bay CA, US
Douglas Michael Ackermann - San Francisco CA, US
Garrett Cale Smith - San Francisco CA, US
Paul A. Cook - Palo Alto CA, US
Evan S. Luxon - San Francisco CA, US
Andrew A. McGibbon - San Francisco CA, US

G02B 1/04

35115933, 427164, 427535

Embodiments of the technology relate to a contact lens having a core that is covalently coated by a hydrogel layer, and to methods of making such a lens. In one aspect, embodiments provide for a coated contact lens comprising a lens core comprising an outer surface; and a hydrogel layer covalently attached to at least a portion of the outer surface, the hydrogel layer adapted to contact an ophthalmic surface, wherein the hydrogel layer comprises a hydrophilic polymer population having a first PEG species and a second PEG species, the first PEG species being at least partially cross-linked to the second PEG species.

2017024, Aug 24, 2017

May 10, 2017

15/591872

Karen L. HAVENSTRITE - San Francisco CA, US
Victor Wayne MCCRAY - San Jose CA, US
Brandon McNary FELKINS - Half Moon Bay CA, US
Andrew A. MCGIBBON - San Francisco CA, US

G02C 7/04
A61F 9/00
B29D 11/00

Contact lenses with hydrophilic polymer coatings are described herein along with methods of making such lenses. The contact lenses can include a lens core that comprises about 75% to about 100% silicone. The hydrophilic polymer coating can include polyethylene glycol and polyacrylamide.

2016032, Nov 3, 2016

Jul 8, 2016

15/206103

Karen L. HAVENSTRITE - San Francisco CA, US
Victor W. MCCRAY - San Jose CA, US
Brandon M. FELKINS - Half Moon Bay CA, US
Douglas M. ACKERMANN - San Francisco CA, US
Garrett C. SMITH - San Francisco CA, US
Paul A. COOK - Palo Alto CA, US
Evan S. LUXON - San Francisco CA, US
Andrew A. MCGIBBON - San Francisco CA, US

G02C 7/04
C09D 105/08
C09D 171/00
C08L 5/08
G02B 1/04
C08L 71/00

Embodiments of the technology relate to a contact lens having a core that is covalently coated by a hydrogel layer, and to methods of making such a lens. In one aspect, embodiments provide for a coated contact lens comprising a lens core comprising an outer surface; and a hydrogel layer covalently attached to at least a portion of the outer surface, the hydrogel layer adapted to contact an ophthalmic surface, wherein the hydrogel layer comprises a hydrophilic polymer population having a first PEG species and a second PEG species, the first PEG species being at least partially cross-linked to the second PEG species.

2016022, Aug 4, 2016

Apr 11, 2016

15/095759

Karen L. HAVENSTRITE - San Francisco CA, US
Victor Wayne MCCRAY - San Jose CA, US
Brandon McNary FELKINS - Half Moon Bay CA, US
Paul A. COOK - Palo Alto CA, US

G02C 7/04
A61B 5/02
A61B 5/01
G02B 1/04
A61B 5/145

Embodiments of the technology relate to a contact lens having a core that is coated by a hydrogel layer, and to methods of making such a lens. The coated lens can include a rigid gas permeable contact lens. The coated lens can also include a hybrid silicone and rigid gas permeable contact lens. In one aspect, embodiments provide for a coated contact lens comprising a lens core with a water equilibrium constant of less than about 2% comprising an outer surface; and a hydrogel layer covalently attached to at least a portion of the outer surface, the hydrogel layer adapted to contact an ophthalmic surface, wherein the hydrogel layer comprises a hydrophilic polymer population of one or more species.

2015023, Aug 20, 2015

Mar 17, 2015

14/660728

Karen L. HAVENSTRITE - San Francisco CA, US
Victor Wayne MCCRAY - San Jose CA, US
Brandon McNary FELKINS - Half Moon Bay CA, US
Paul A. COOK - Palo Alto CA, US

G02C 7/04
G02B 1/04

Embodiments of the technology relate to a contact lens having a core that is coated by a hydrogel layer, and to methods of making such a lens. The coated lens can include a rigid gas permeable contact lens. The coated lens can also include a hybrid silicone and rigid gas permeable contact lens. In one aspect, embodiments provide for a coated contact lens comprising a lens core with a water equilibrium constant of less than about 2% comprising an outer surface; and a hydrogel layer covalently attached to at least a portion of the outer surface, the hydrogel layer adapted to contact an ophthalmic surface, wherein the hydrogel layer comprises a hydrophilic polymer population of one or more species.