Karl O Gelotte Deceased525 Johnston Ave, Plainfield, NJ 07069

6441235, Aug 27, 2002

May 14, 2001

09/855124

Edward David Parady - Castleton NY
Karl Olaf Gelotte - Watchung NJ

Amersha, Health AS - Oslo

C07C23102

564157, 564139, 564416, 564418

A process for preparing 5-amino-N,Nâ-bis(R)isophthalamides, where A is 2,3-dihydroxypropyl or 1,3-dihydroxyisopropyl, useful as intermediates in preparing iodinated diagnostic agents, which comprises reacting a di-lower-alkyl 5-nitroisophthalate with a compound of the formula RNH in the presence of a basic catalyst and without isolating the intermediate 5-nitro-N,Nâ-bis(R)isophthalamide, catalytically hydrogenating the latter.

5096919, Mar 17, 1992

Nov 20, 1989

7/439731

Jan W. F. Wasley - Chatham NJ
Karl O. Gelotte - Watchung NJ
Harold Meckler - Union NJ

Ciba-Geigy Corporation - Ardsley NY

A61K 3140
C07D20730

514427

Disclosed are the pyrrolylphenyl-substituted hydroxamic acid derivatives of the formula ##STR1## wherein R represents hydrogen, lower alkyl, halogen or lower alkoxy; R. sub. 1 and R. sub. 2 independently represent hydrogen, lower alkyl or aryl; Y represents a direct bond, lower alkylene, lower alkenylene, lower alkadienylene, (thio, sulfinyl or sulfonyl)-lower alkylene or oxy-lower alkylene; Z represents ##STR2## wherein R. sub. 3 represents hydrogen or acyl; R. sub. 4 represents lower alkyl, C. sub. 3 -C. sub. 7 -cycloalkyl, aryl or aryl-lower alkyl; or Z represents ##STR3## wherein R. sub. 3 represents hydrogen or acyl; R. sub. 5 represents lower alkyl, C. sub. 3 -C. sub. 7 -cycloalkyl, aryl, aryl-lower alkyl, amino or N-(mono- or di-lower alkyl)-amino; R. sub. 6 and R. sub. 7 represent hydrogen or lower alkyl; and pharmaceutically acceptable salts thereof provided that R. sub. 3 represents hydrogen; which are useful as selective lipoxygenase inhibitors, methods for preparation thereof, pharmaceutical compositions comprising said compounds, and a method of inhibiting lipoxygenase and of treating diseases in mammals which are responsive to lipoxygenase inhibition using said compounds and pharmaceutical compositions comprising said compounds of the invention.

4609733, Sep 2, 1986

Dec 27, 1984

6/686777

Stephen K. Boyer - Far Hills NJ
Karl O. Gelotte - Watchung NJ
Joseph Bach - Parsippany NJ

Ciba-Geigy Corporation - Ardsley NY

C07D40104

546273

Disclosed is a process for the preparation of a compound of the formula ##STR1## wherein Ar is 3- or 4-pyridyl or 3- or 4-pyridyl substituted by lower alkyl; R. sub. 1 is hydrogen, halogen, trifluoromethyl, lower alkyl, hydroxy, acylated or etherified hydroxy, lower alkylthio; or two of R. sub. 1 on adjacent carbon atoms represent alkylenedioxy; p is 1 or 2; R. sub. 2 represents hydrogen or lower alkyl; E represents C. sub. 1 -C. sub. 11 alkylene, C. sub. 1 -C. sub. 6 alkylenephenylene, C. sub. 1 -C. sub. 6 alkylene-(thio or oxy)-lower alkylene, C. sub. 1 -C. sub. 6 alkylene-(thio or oxy)-phenylene, C. sub. 1 -C. sub. 6 alkylenephenylene-lower alkylene, phenylene-lower alkylene; or E represents a direct bond; and B represents carboxy, esterified carboxy or carbamoyl; which comprises deoxygenating the keto group in a compound of the formula ##STR2## wherein Ar, R. sub. 1, R. sub. 2, p, E and B have meaning as defined above.

4713383, Dec 15, 1987

Mar 26, 1986

6/844447

John E. Francis - Basking Ridge NJ
Karl O. Gelotte - Watchung NJ

Ciba-Geigy Corporation - Ardsley NY

A61K 31505
C07D48704

514267

[1,2,4]triazolo[1,5-c]quinazoline compounds of the formula ##STR1## wherein R. sub. 1 is optionally substituted phenyl, pyridyl, furyl thienyl, dihydro or tetrahydro furanyl or thienyl, pyranyl, or 0-ribofuranosyl; R. sub. 2 is hydrogen or lower alkyl; X is oxygen or NR. sub. 3, R. sub. 3 is as defined in the claims, and ring A is unsubstituted or substituted as set forth in the claims. The compounds wherein X is N--R. sub. 3 are especially useful as adenosine antagonists and for the treatment of asthma. The compounds wherein X is oxygen are useful as benzodiazepine antagonists and as intermediates in the synthesis of the compounds wherein X is N--R. sub. 3.

4755595, Jul 5, 1988

Nov 1, 1985

6/793934

Karl O. Gelotte - Watchung NJ
Chester J. Opalka - Schodack NY

Sterling Drug Inc. - New York NY

C07J 7100

540 57

An improvement in the epoxidation of certain 4,5-unsaturated steroids with peracetic acid, which comprises carrying out the reaction in methanol solution.