Inventors:
Shengde Wu - Wester Chester OH, US
Namal C. Warshakoon - Mason OH, US
Artem G. Evdokimov - Niantic CT, US
Kenneth D. Greis - Fort Thomas KY, US
Angelique Sun Boyer - West Chester OH, US
Richard Masaru Kawamoto - Divide CO, US
Assignee:
Akebia Therapeutics Inc. - Cincinnati OH
International Classification:
A61K 31/4418
A61K 31/4439
A61K 31/444
A61K 31/506
A61K 31/4725
A61K 31/4427
A61K 31/4433
C07D 213/81
C07D 401/10
C07D 401/04
C07D 405/10
A61P 17/02
A61P 7/06
US Classification:
51421018, 514346, 514343, 514340, 514334, 514256, 514307, 514342, 514338, 546291, 5462791, 5462684, 546257, 546144, 5462704, 5462824
Abstract:
The present disclosure relates to HIF-1α prolyl hydroxylase inhibitors, compositions which comprise the HIF-1α prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia.