Inventors:
Joseph Armstrong Martin - Menlo Park CA, US
Keshab Sarma - Sunnyvale CA, US
David Bernard Smith - San Mateo CA, US
Mark Smith - San Francisco CA, US
Assignee:
Roche Palo Alto LLC - Palo Alto CA
International Classification:
A61K 317068
A61K 317052
A61K 3170
C07H 19067
US Classification:
514 49, 514934, 514894, 536 2851, 536 285, 536 553
Abstract:
The present invention relates to nucleoside derivatives for the treatment of Hepatitis C viral infections including compounds of formula I, pharmaceutical compositions comprising these compounds and methods for treatment or prophylaxis of Hepatitis C Virus mediated diseases employing said compounds in monotherapy or in combination therapy. The present invention further provides a process for preparing 1′,3′,4′-triacyl pyrimidine nucleoside from a N, 1′,3′,4′-tetraacylpyrimidine nucleoside.