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Keshab Te Sarma, Age 68Kinnelon, NJ

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Known as:
Keshab J Sarma Keshab G Sarma Kesahb Sarma Keshab Saima

Keshab Sarma Phones & Addresses

Kinnelon, NJ

Foster City, CA

517 Davenport Ct, Sunnyvale, CA 94087 (408) 773-9462

Mountain View, CA

Stockholm, NJ

Cambridge, MA

West Palm Bch, FL

Morgan, NJ

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Mentions for Keshab Te Sarma

Keshab Sarma resumes & CV records

Resumes

Keshab Sarma Photo 9

Principal Scientist At Gilead Sciences Inc.

Position:
Principal Scientist at Gilead Sciences
Location:
San Francisco Bay Area
Industry:
Pharmaceuticals
Work:
Gilead Sciences since May 2011
Principal Scientist Hoffmann-La Roche Inc. Sep 2009 - May 2011
Research Leader Hoffmann-La Roche in Nutley (New Jersey) 2009 - May 2011
Research Leader
Education:
Harvard University 1988 - 1990
Post Doctoral Fellow, Organic Chemistry Hochschule Karlsruhe - Technik und Wirtschaft 1979 - 1982
Gauhati University
Keshab Sarma Photo 10

Keshab Sarma

Publications & IP owners

Us Patents

Antiviral Nucleoside Derivatives

US Patent:
6846810, Jan 25, 2005
Filed:
Nov 19, 2003
Appl. No.:
10/717260
Inventors:
Joseph Armstrong Martin - Menlo Park CA, US
Keshab Sarma - Sunnyvale CA, US
David Bernard Smith - San Mateo CA, US
Mark Smith - San Francisco CA, US
Assignee:
Roche Palo Alto LLC - Palo Alto CA
International Classification:
A61K 317068
A61K 317052
A61K 3170
C07H 19067
US Classification:
514 49, 514934, 514894, 536 2851, 536 285, 536 553
Abstract:
The present invention relates to nucleoside derivatives for the treatment of Hepatitis C viral infections including compounds of formula I, pharmaceutical compositions comprising these compounds and methods for treatment or prophylaxis of Hepatitis C Virus mediated diseases employing said compounds in monotherapy or in combination therapy. The present invention further provides a process for preparing 1′,3′,4′-triacyl pyrimidine nucleoside from a N, 1′,3′,4′-tetraacylpyrimidine nucleoside.

Anhydrous Crystalline 1-[4(S)-Azido-2(S),3(R)-Dihydroxy-4-(Hydroxymethyl)-1(R)-Cyclopentyl]Cytosine Hemisulfate As Useful As An Antiviral Agent

US Patent:
6864244, Mar 8, 2005
Filed:
Dec 9, 2003
Appl. No.:
10/731582
Inventors:
Terrence Joseph Connolly - Redwood City CA, US
Joseph Armstrong Martin - Menlo Park CA, US
Anthony Prince - Los Altos CA, US
Keshab Sarma - Sunnyvale CA, US
Assignee:
Roche Palo Alto LLC - Palo Alto CA
International Classification:
A61K031/7068
A61K031/7052
A61K031/70
C07H019/067
US Classification:
514 49, 514934, 514894, 536 2851, 536 285, 536 553
Abstract:
The present invention relates to the hemisulfate salt of 1-[4(S)-azido-2(S),3(R)-dihydroxy-4-(hydroxymethyl)-1(R)-cyclopentyl]cytosine (Ia) with improved stability and physical properties which facilitate manufacturing, handling and formulating I and polymorphic crystalline forms thereof.

Anti-Viral Nucleosides

US Patent:
7378402, May 27, 2008
Filed:
Aug 22, 2005
Appl. No.:
11/208510
Inventors:
Joseph Armstrong Martin - Hertfordshire, GB
Keshab Sarma - Sunnyvale CA, US
David Bernard Smith - San Mateo CA, US
Mark Smith - San Francisco CA, US
Assignee:
Roche Palo Alto LLC - Palo Alto CA
International Classification:
C07H 19/00
C07H 19/06
A01N 43/04
A61K 31/70
US Classification:
514 49, 536 281, 536 284, 536 285, 536 2851
Abstract:
4-Amino-1-((2R,3S,4S,5R)-5-azido-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (I:R=R=R=R=H) and prodrugs thereof are hepatitis C(HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.

Selective O-Acylation Of Nucleosides

US Patent:
7439344, Oct 21, 2008
Filed:
Sep 22, 2006
Appl. No.:
11/525889
Inventors:
Keshab Sarma - Sunnyvale CA, US
Assignee:
Roche Palo Alto LLC - Palo Alto CA
International Classification:
C07G 3/00
C07H 15/00
C07H 17/00
A01N 43/04
A61K 31/70
US Classification:
536 186, 536 185, 536 253
Abstract:
The present invention relates to a one-step process for the selective O-acylation of the hydroxy groups of a nucleoside under basic conditions utilizing DMAP and a carboxylic acid anhydride in aqueous heterogenous solvent mixture.

Methods For Synthesis Of 3-Amino-1-Arylpropyl Indoles

US Patent:
7598399, Oct 6, 2009
Filed:
Nov 29, 2006
Appl. No.:
11/605648
Inventors:
Terrence Joseph Connolly - Warwick NY, US
Robert P. Farrell - Mountain View CA, US
Eric Roy Humphreys - San Bruno CA, US
Stephen M. Lynch - San Jose CA, US
Keshab Sarma - Sunnyvale CA, US
Assignee:
Roche Palo Alto LLC - Palo Alto CA
International Classification:
C07D 209/18
US Classification:
548495
Abstract:
A method comprising:.

Process For The Preparation Of 4′-Azido Cytidine Derivatives

US Patent:
7632940, Dec 15, 2009
Filed:
Dec 7, 2007
Appl. No.:
11/999926
Inventors:
Peter John Harrington - Louisville CO, US
Stefan Hildbrand - Moehlin, CH
Keshab Sarma - Sunnyvale CA, US
Assignee:
Roche Palo Alto LLC - Palo Alto CA
International Classification:
C07H 21/00
US Classification:
536 253, 536 221, 536 2531, 536 281, 536 284, 536 285
Abstract:
The invention relates to a novel process for the preparation of 4′-azido-cytidine (I) or a.

Process For The Preparation Of 3-Amino-Pentan-1,5-Diol

US Patent:
7635784, Dec 22, 2009
Filed:
Jun 9, 2008
Appl. No.:
12/135240
Inventors:
Thomas Cleary - Florence SC, US
Yaohui Ji - Florence SC, US
Gary R. Lee - Belmont CA, US
Thimma Rawalpally - Florence SC, US
Keshab Sarma - Sunnyvale CA, US
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
Roche Palo Alto LLC - Palo Alto CA
International Classification:
C07C 269/00
US Classification:
560157, 560160
Abstract:
The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-1,5-diol (2), which is useful for the preparation of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one (1) a MAP-kinase inhibitor useful in the treatment of rheumatoid arthritis.

Antiviral Nucleosides

US Patent:
7645745, Jan 12, 2010
Filed:
Apr 4, 2007
Appl. No.:
11/732983
Inventors:
Keshab Sarma - Sunnyvale CA, US
Assignee:
Roche Palo Alto LLC - Palo Alto CA
International Classification:
A01N 43/04
A61K 31/70
C07H 19/00
US Classification:
514 49, 536 285, 536 2851
Abstract:
Compounds having the formula I wherein Ris as herein defined are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis replication, processes for making the compounds and synthetic intermediates used in the process.

Possible Relatives

Gopal P Sarma  Akella S Sarma  Akkaraju V Sarma  Pat B Sarma  Sumitra S Sarma 

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