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Lance C Simpson, Age 475151 Gramercy Dr, Clifton Heights, PA 19018

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Known as:
Lance Cooper Simpson Lance C Boyce
Related to:
Becky C Boyce 47 Christina M Boyce

Lance Simpson Phones & Addresses

Clifton Heights, PA

Newtown Square, PA

Drexel Hill, PA

Woodlyn, PA

Glenolden, PA

Media, PA

Haverford, PA

Havertown, PA

Mullica Hill, NJ

Havertown, PA

2228 Steele Rd, Drexel Hill, PA 19026

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Work

Position: Professional/Technical

Education

Degree: High school graduate or higher

Mentions for Lance C Simpson

Lance Simpson resumes & CV records

Resumes

Lance Simpson Photo 45

Lance Simpson

Location:
United States
Lance Simpson Photo 46

Lance Simpson

Location:
United States
Lance Simpson Photo 47

Police Officer At Upper Darby Township Police Department

Location:
Greater Philadelphia Area
Industry:
Law Enforcement

Publications & IP owners

Us Patents

Mutant Botulinum Neurotoxin Serotype A Polypeptide And Uses Thereof

US Patent:
8445650, May 21, 2013
Filed:
Sep 25, 2008
Appl. No.:
12/679936
Inventors:
Lance L. Simpson - Moorestown NJ, US
Mohammed Elias - Voorhees NJ, US
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
A61K 39/08
C12P 21/06
US Classification:
5303911, 530350, 4241901
Abstract:
Modified polypeptides based on the neurotoxin A heavy chain containing the double mutation Trp-Tyr->Leu-Ser in the ganglioside binding motif Ser-X-Trp-Tyr do not bind polysialogangliosides and nerve endings. The polypeptides are useful in the preparation of nontoxic vaccines against the effects of infection. The modified polypeptides are also useful as vehicles for the transepithelial delivery of diagnostic and therapeutic entities, through formation of conjugates between the polypeptides and the diagnostic or therapeutic entities.

Compositions And Methods For Transepithelial Molecular Transport

US Patent:
2004001, Jan 22, 2004
Filed:
Jun 2, 2003
Appl. No.:
10/452024
Inventors:
Lance Simpson - Moorestown NJ, US
Andrew Maksymowych - Gulph Mills PA, US
Assignee:
Thomas Jefferson University
International Classification:
A61K039/02
US Classification:
424/190100
Abstract:
The invention relates to fragments of HC that can be linked with an entity (e.g., an antigen, a particle, or a radionuclide) and used to deliver the entity across a non-keratinized epithelial membrane of an animal. The fragments are useful, for example, for making vaccines, antidotes, and anti-toxins and in situations in which rapid uptake of an agent by an animal is desired.

Compositions And Methods For Transepithelial Molecular Transport

US Patent:
2009005, Feb 26, 2009
Filed:
Mar 25, 2008
Appl. No.:
12/079294
Inventors:
Lance Simpson - Moorestown NJ, US
Andrew Maksymowych - Gulph Mills PA, US
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
A61K 39/385
A61K 39/395
C07K 16/00
A61P 37/04
US Classification:
4241831, 42419711, 4241941, 5303917
Abstract:
The invention relates to fragments of HC that can be linked with an entity (e.g., an antigen, a particle, or a radionuclide) and used to deliver the entity across a non-keratinized epithelial membrane of an animal. The fragments are useful, for example, for making vaccines, antidotes, and anti-toxins and in situations in which rapid uptake of an agent by an animal is desired.

Monoclonal Antibodies That Neutralize Botulinum Neurotoxin

US Patent:
2010022, Sep 2, 2010
Filed:
Jun 19, 2006
Appl. No.:
11/455507
Inventors:
Scott K. Dessain - Wynnewood PA, US
Lance L. Simpson - Moorestown NJ, US
Sharad P. Adekar - Secane PA, US
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
C07K 16/12
C07K 14/00
C07H 21/04
A61K 39/395
A61P 43/00
G01N 33/53
US Classification:
5303873, 5303871, 530350, 536 231, 4241671, 4241351, 436501
Abstract:
This invention provides antibodies that specifically bind to botulinum neurotoxin type A (BoNT/A) and/or botulinum neurotoxin type B (BoNT/B) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism. Also included in the invention are diagnostic and therapeutic assays directed to botulinum neurotoxins.

Compositions And Methods For Systemic Delivery Of Oral Vaccines And Therapeutic Agents

US Patent:
6051239, Apr 18, 2000
Filed:
Oct 20, 1997
Appl. No.:
8/954302
Inventors:
Lance Simpson - Moorestown NJ
Nikita Kiyatkin - Cherry Hill NJ
Andrew Maksymowych - Gulph Mills PA
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
A61K 3908
C07K 1433
C07K 1900
US Classification:
4242391
Abstract:
Compositions and methods of oral delivery of an antigen or therapeutic agent to the general circulation using a modified botulinum toxin which is capable of translocating from the gut to the general circulation but which is altered to be nontoxic are provided.

Isbn (Books And Publications)

Neuropoisons; Their Pathophysiological Actions

Author:
Lance L. Simpson
ISBN #:
0306371219

Botulinum Neurotoxin And Tetanus Toxin

Author:
Lance L. Simpson
ISBN #:
0126444455

Drug Treatment Of Mental Disorders

Author:
Lance L. Simpson
ISBN #:
0890040079

Possible Relatives

Dale R Simpson  Dallas Simpson  Damian L Simpson  Debi A Simpson  Daniel D Simpson  Deeann L Simpson  Delmar O Simpson  Lance M Johnston  Lance C White  Lance L Stanley 

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